Perceptive Advisors LLC

Period:: Q1 2026
Portfolio date:: Mar 31, 2026
No. of stocks:: 91
Portfolio value:: $5,110,912,000
Filed:: May 15, 2026
CIK:: 1224962

Hist	Stock	Activity	Share change	% change to portfolio
Q1 2026filed May 15, 2620 new17 added22 reduced42 exited
≡	XBIPUT – SPDR SERIES TRUST	Sell	−1,100,000	−2.39
≡	EXAS – EXACT SCIENCES CORP	Sell	−1,200,487	−2.17
≡	ACLX – ARCELLX INC	Sell	−1,466,071	−1.70
≡	BSX – BOSTON SCIENTIFIC CORP	Sell	−979,000	−1.66
≡	AMICUS THERAPEUTICS INC	Sell	−6,370,851	−1.62
≡	ASTRIA THERAPEUTICS INC	Sell	−6,485,420	−1.51
≡	VRDN – VIRIDIAN THERAPEUTICS INC	Reduce 62.00%	−1,871,874	−1.24
≡	RYTM – RHYTHM PHARMACEUTICALS INC	Reduce 7.00%	−172,596	−0.82
≡	DHR – DANAHER CORPORATION	Sell	−200,000	−0.82
≡	BLTE – BELITE BIO INC	Reduce 63.00%	−262,260	−0.71
≡	NBIX – NEUROCRINE BIOSCIENCES INC	Reduce 80.00%	−266,000	−0.67
≡	CDTX – CIDARA THERAPEUTICS INC	Sell	−165,131	−0.65
≡	IRON – DISC MEDICINE INC	Sell	−450,743	−0.64
≡	PEN – PENUMBRA INC	Sell	−110,529	−0.61
≡	APGE – APOGEE THERAPEUTICS INC	Reduce 34.00%	−790,267	−0.60
≡	CAI – CARIS LIFE SCIENCES INC	Sell	−1,136,206	−0.55
≡	RAPT THERAPEUTICS INC	Sell	−825,890	−0.50
≡	PVLA – PALVELLA THERAPEUTICS INC NE	Sell	−266,287	−0.50
≡	OMDA – OMADA HEALTH INC	Reduce 67.00%	−1,610,000	−0.48
≡	PTGX – PROTAGONIST THERAPEUTICS INC	Reduce 9.00%	−119,546	0.44
≡	KOD – KODIAK SCIENCES INC	Sell	−848,900	−0.42
≡	BIIB – BIOGEN INC	Sell	−124,000	−0.39
≡	ALDX – ALDEYRA THERAPEUTICS INC	Sell	−4,185,632	−0.39
≡	ABVX – ABIVAX SA	Reduce 28.00%	−129,459	−0.39
≡	MIRM – MIRUM PHARMACEUTICALS INC	Sell	−259,545	−0.37
≡	GRAL – GRAIL INC	Sell	−237,342	−0.36
≡	SION – SIONNA THERAPEUTICS INC	Reduce 44.00%	−520,659	−0.35
≡	CVS – CVS HEALTH CORP	Sell	−220,000	−0.31
≡	GKOS – GLAUKOS CORP	Sell	−140,000	−0.28
≡	RGEN – REPLIGEN CORP	Reduce 11.00%	−35,000	−0.27
≡	DXCM – DEXCOM INC	Sell	−225,758	−0.27
≡	SVRA – SAVARA INC	Sell	−2,400,000	−0.26
≡	SEPN – SEPTERNA INC	Sell	−433,160	−0.22
≡	ADMA – ADMA BIOLOGICS INC	Reduce 47.00%	−416,235	−0.20
≡	PALI – PALISADE BIO INC	Reduce 26.00%	−3,121,851	−0.20
≡	GOSS – GOSSAMER BIO INC	Sell	−3,139,669	−0.17
≡	MPLT – MAPLIGHT THERAPEUTICS INC	Sell	−550,000	−0.17
≡	XENE – XENON PHARMACEUTICALS INC	Sell	−200,791	−0.16
≡	KMTS – KESTRA MED TECHNOLOGIES LTD	Sell	−285,000	−0.13
≡	IMVT – IMMUNOVANT INC	Reduce 20.00%	−397,507	−0.13
≡	CAPRCALL – CAPRICOR THERAPEUTICS INC	Sell	−242,100	−0.12
≡	IKT – INHIBIKASE THERAPEUTICS INC	Reduce 57.00%	−3,106,568	−0.12
≡	BHVNCALL – BIOHAVEN LTD	Sell	−500,000	−0.10
≡	ADGM – ADAGIO MED HLDGS INC	Reduce 62.00%	−6,095,746	−0.10
≡	KYMR – KYMERA THERAPEUTICS INC	Sell	−69,935	−0.10
≡	PEPG – PEPGEN INC	Sell	−829,870	−0.10
≡	TECXCALL – TECTONIC THERAPEUTIC INC	Sell	−250,000	−0.09
≡	AQST – AQUESTIVE THERAPEUTICS INC	Sell	−747,193	−0.09
≡	DRUG – BRIGHT MINDS BIOSCIENCES INC	Reduce 16.00%	−71,746	−0.09
≡	KRYS – KRYSTAL BIOTECH INC	Sell	−17,500	−0.08
≡	OLMA – OLEMA PHARMACEUTICALS INC	Sell	−165,713	−0.07
≡	SDGR – SCHRODINGER INC	Sell	−202,400	−0.06
≡	IMMX – IMMIX BIOPHARMA INC	Sell	−338,941	−0.03
≡	LXEO – LEXEO THERAPEUTICS INC	Sell	−139,835	−0.02
≡	CTNM – CONTINEUM THERAPEUTICS INC	Reduce 14.00%	−209,000	0.02
≡	CBIO – CRESCENT BIOPHARMA INC.	Reduce 54.00%	−246,744	−0.02
≡	LENZ – LENZ THERAPEUTICS INC	Sell	−50,000	−0.01
≡	BDSX – BIODESIX	Sell	−108,694	−0.01
≡	CPIX – CUMBERLAND PHARMACEUTICALS I	Reduce 42.00%	−144,109	−0.01
≡	NVNO – ENVVENO MEDICAL CORPORATION	Sell	−1,759,035	−0.01
≡	IRD – OPUS GENETICS INC	Reduce 58.00%	−2,489,158	0.01
≡	IOVA – IOVANCE BIOTHERAPEUTICS INC	Sell	−152,714	−0.01
≡	AXGN – AXOGEN INC	Reduce 11.00%	−86,828	−0.01
≡	PTN – PALATIN TECHNOLOGIES INC	Reduce 12.00%	−8,055	0.00
Q4 2025filed Feb 17, 2641 new31 added17 reduced15 exited
≡	ACLX – ARCELLX INC	Reduce 41.00%	−1,002,282	−4.02
≡	MERUS N V	Sell	−1,353,093	−3.60
≡	INSM – INSMED INC	Sell	−702,130	−2.86
≡	AMLX – AMYLYX PHARMACEUTICALS INC	Reduce 7.00%	−667,483	−1.65
≡	VRNA – VERONA PHARMA PLC	Sell	−524,088	−1.58
≡	AKERO THERAPEUTICS INC	Sell	−1,135,766	−1.52
≡	MGTX – MEIRAGTX HLDGS PLC	Reduce 18.00%	−2,300,000	−1.47
≡	AORT – ARTIVION INC	Reduce 15.00%	−297,710	−1.02
≡	PEN – PENUMBRA INC	Reduce 50.00%	−110,018	−0.97
≡	NBIX – NEUROCRINE BIOSCIENCES INC	Reduce 26.00%	−119,000	−0.95
≡	CNTA – CENTESSA PHARMACEUTICALS PLC	Reduce 6.00%	−183,268	−0.82
≡	AQST – AQUESTIVE THERAPEUTICS INC	Reduce 80.00%	−3,012,906	−0.51
≡	ALDX – ALDEYRA THERAPEUTICS INC	Reduce 20.00%	−1,036,679	−0.38
≡	IRTC – IRHYTHM TECHNOLOGIES INC	Reduce 12.00%	−15,000	−0.26
≡	CRVS – CORVUS PHARMACEUTICALS INC	Reduce 52.00%	−746,154	−0.20
≡	PVLA – PALVELLA THERAPEUTICS INC NE	Reduce 33.00%	−128,806	−0.20
≡	JANX – JANUX THERAPEUTICS INC	Sell	−292,686	−0.20
≡	TEM – TEMPUS AI INC	Sell	−85,000	−0.19
≡	ADMA – ADMA BIOLOGICS INC	Reduce 23.00%	−270,000	−0.19
≡	KYMR – KYMERA THERAPEUTICS INC	Reduce 59.00%	−99,861	−0.17
≡	HTFL – HEARTFLOW INC	Sell	−150,000	−0.14
≡	GOSS – GOSSAMER BIO INC	Reduce 18.00%	−673,128	−0.11
≡	KRYS – KRYSTAL BIOTECH INC	Reduce 50.00%	−17,500	−0.10
≡	SCPHARMACEUTICALS INC	Sell	−583,142	−0.09
≡	VKTX – VIKING THERAPEUTICS INC	Sell	−105,597	−0.08
≡	PYXS – PYXIS ONCOLOGY INC	Sell	−1,178,307	−0.07
≡	SEPN – SEPTERNA INC	Reduce 20.00%	−108,290	−0.07
≡	SPRYPUT – ARS PHARMACEUTICALS INC	Sell	−200,000	−0.06
≡	TRIB – TRINITY BIOTECH PLC	Sell	−1,790,000	−0.05
≡	LYRA – LYRA THERAPEUTICS INC	Sell	−229,382	−0.04
≡	QURE – UNIQURE NV	Sell	−20,000	−0.03
≡	APYX – APYX MEDICAL CORPORATION	Sell	−150,000	−0.01
Q3 2025filed Nov 14, 2521 new28 added14 reduced13 exited
≡	VRNA – VERONA PHARMA PLC	Reduce 90.00%	−4,983,503	−17.25
≡	RYTM – RHYTHM PHARMACEUTICALS INC	Reduce 100.00%	−2,418,299	−4.34
≡	SLNO – SOLENO THERAPEUTICS INC	Sell	−430,439	−1.30
≡	XBIPUT – SPDR SERIES TRUST	Sell	−300,000	−0.90
≡	EOLS – EVOLUS INC	Sell	−2,474,843	−0.82
≡	AORT – ARTIVION INC	Reduce 28.00%	−773,703	−0.73
≡	PODD – INSULET CORP	Sell	−60,387	−0.69
≡	BBNX – BETA BIONICS INC	Reduce 83.00%	−1,315,664	−0.68
≡	DYN – DYNE THERAPEUTICS INC	Reduce 76.00%	−1,706,946	−0.58
≡	CRL – CHARLES RIV LABS INTL INC	Sell	−100,000	−0.55
≡	IMVT – IMMUNOVANT INC	Reduce 26.00%	−550,000	−0.51
≡	EWTX – EDGEWISE THERAPEUTICS INC	Reduce 18.00%	−844,055	−0.46
≡	ADMA – ADMA BIOLOGICS INC	Reduce 12.00%	−150,000	−0.38
≡	RARE – ULTRAGENYX PHARMACEUTICAL IN	Sell	−270,000	−0.35
≡	VKTX – VIKING THERAPEUTICS INC	Reduce 72.00%	−275,103	−0.29
≡	SYRE – SPYRE THERAPEUTICS INC	Reduce 20.00%	−300,000	−0.25
≡	AXSM – AXSOME THERAPEUTICS INC	Reduce 25.00%	−49,634	−0.24
≡	CAPRPUT – CAPRICOR THERAPEUTICS INC	Sell	−650,000	−0.23
≡	GMED – GLOBUS MED INC	Sell	−88,500	−0.19
≡	HLXC – HELIX ACQUISITION CORP II	Sell	−398,000	−0.15
≡	AMICUS THERAPEUTICS INC	Reduce 14.00%	−1,041,979	−0.12
≡	KYMR – KYMERA THERAPEUTICS INC	Reduce 19.00%	−40,310	−0.06
≡	LONA – ATHIRA PHARMA INC	Sell	−5,402,964	−0.06
≡	LYRA – LYRA THERAPEUTICS INC	Reduce 10.00%	−25,768	−0.04
≡	FBRX – FORTE BIOSCIENCES INC	Sell	−68,192	−0.03
≡	BDSX – BIODESIX INC	Sell	−2,173,880	−0.02
≡	KALA – KALA BIO INC	Sell	−55,227	−0.01
Q2 2025filed Aug 14, 2522 new8 added27 reduced23 exited
≡	AMICUS THERAPEUTICS INC	Reduce 65.00%	−14,051,697	−4.60
≡	VRNA – VERONA PHARMA PLC	Reduce 16.00%	−1,055,749	4.23
≡	INTRA-CELLULAR THERAPIES INC	Sell	−786,358	−3.64
≡	SLNO – SOLENO THERAPEUTICS INC	Reduce 71.00%	−1,076,163	−2.47
≡	IOVA – IOVANCE BIOTHERAPEUTICS INC	Sell	−12,711,788	−1.48
≡	ALDX – ALDEYRA THERAPEUTICS INC	Reduce 56.00%	−5,224,220	−1.31
≡	ARGX – ARGENX SE	Sell	−59,510	−1.23
≡	CNTA – CENTESSA PHARMACEUTICALS PLC	Reduce 62.00%	−1,893,460	−0.99
≡	PCVX – VAXCYTE INC	Sell	−706,567	−0.94
≡	EOLS – EVOLUS INC	Reduce 40.00%	−1,654,299	−0.92
≡	ACLX – ARCELLX INC	Reduce 15.00%	−448,478	−0.83
≡	AXSM – AXSOME THERAPEUTICS INC	Reduce 44.00%	−156,573	−0.70
≡	JANX – JANUX THERAPEUTICS INC	Reduce 70.00%	−677,726	−0.67
≡	MDGL – MADRIGAL PHARMACEUTICALS INC	Sell	−46,500	−0.54
≡	SYRE – SPYRE THERAPEUTICS INC	Reduce 34.00%	−783,827	−0.48
≡	IMVT – IMMUNOVANT INC	Reduce 25.00%	−706,182	−0.47
≡	DXCM – DEXCOM INC	Sell	−178,000	−0.43
≡	ACRV – ACRIVON THERAPEUTICS INC	Sell	−5,360,858	−0.38
≡	CRGX – CARGO THERAPEUTICS INC	Sell	−2,431,085	−0.35
≡	EYPT – EYEPOINT PHARMACEUTICALS INC	Sell	−1,537,274	−0.29
≡	NUVL – NUVALENT INC	Reduce 16.00%	−258,788	−0.27
≡	IRON – DISC MEDICINE INC	Sell	−150,000	−0.26
≡	CTNM – CONTINEUM THERAPEUTICS INC	Reduce 51.00%	−741,763	−0.25
≡	ADPT – ADAPTIVE BIOTECHNOLOGIES COR	Sell	−930,972	−0.24
≡	OCUL – OCULAR THERAPEUTIX INC	Sell	−915,775	−0.24
≡	DCTH – DELCATH SYS INC	Sell	−462,422	−0.21
≡	ZYME – ZYMEWORKS INC	Reduce 32.00%	−589,398	−0.20
≡	RAPT THERAPEUTICS INC	Sell	−4,418,947	−0.19
≡	KMTS – KESTRA MED TECHNOLOGIES LTD	Sell	−200,000	−0.17
≡	PRAX – PRAXIS PRECISION MEDICINES I	Reduce 23.00%	−227,973	−0.16
≡	XENE – XENON PHARMACEUTICALS INC	Reduce 38.00%	−124,533	−0.16
≡	OKUR – ONKURE THERAPEUTICS INC	Sell	−1,004,439	−0.15
≡	AVTX – AVALO THERAPEUTICS INC	Reduce 73.00%	−380,333	−0.12
≡	AQST – AQUESTIVE THERAPEUTICS INC	Reduce 41.00%	−1,536,788	−0.12
≡	BBNX – BETA BIONICS INC	Reduce 28.00%	−610,232	−0.11
≡	VRDN – VIRIDIAN THERAPEUTICS INC	Reduce 32.00%	−212,155	−0.09
≡	IKT – INHIBIKASE THERAPEUTICS INC	Reduce 8.00%	−492,707	−0.07
≡	MREO – MEREO BIOPHARMA GROUP PLC	Sell	−876,961	−0.07
≡	VKTX – VIKING THERAPEUTICS INC	Reduce 25.00%	−128,305	−0.07
≡	LYRA – LYRA THERAPEUTICS INC	Sell	−12,757,562	−0.06
≡	CELC – CELCUITY INC	Reduce 31.00%	−729,071	−0.05
≡	KALA – KALA BIO INC	Reduce 80.00%	−222,383	−0.05
≡	AVR – ANTERIS TECHNOLOGIES GLOBAL	Reduce 20.00%	−434,870	−0.04
≡	TRAW – TRAWS PHARMA INC	Sell	−421,781	−0.03
≡	RCKT – ROCKET PHARMACEUTICALS INC	Sell	−140,726	−0.03
≡	PODD – INSULET CORP	Reduce 16.00%	−11,210	0.03
≡	CGEM – CULLINAN THERAPEUTICS INC	Sell	−80,100	−0.02
≡	INBX – INHIBRX BIOSCIENCES INC	Reduce 8.00%	−86,134	−0.02
≡	APPLIED THERAPEUTICS INC	Sell	−860,000	−0.01
≡	NBTX – NANOBIOTIX	Sell	−105,053	−0.01
Q1 2025filed May 15, 2515 new13 added29 reduced27 exited
≡	IOVA – IOVANCE BIOTHERAPEUTICS INC	Reduce 43.00%	−9,400,478	−2.97
≡	PCVX – VAXCYTE INC	Reduce 59.00%	−1,011,850	−2.89
≡	EWTXCALL – EDGEWISE THERAPEUTICS INC	Reduce 81.00%	−2,185,537	−1.56
≡	NUVL – NUVALENT INC	Reduce 38.00%	−986,009	−1.52
≡	PRAX – PRAXIS PRECISION MEDICINES I	Reduce 26.00%	−348,841	−1.48
≡	CNTA – CENTESSA PHARMACEUTICALS PLC	Reduce 52.00%	−3,308,825	−1.36
≡	CRGX – CARGO THERAPEUTICS INC	Reduce 34.00%	−1,251,919	−1.10
≡	PODD – INSULET CORP	Reduce 69.00%	−160,672	−0.99
≡	RYTM – RHYTHM PHARMACEUTICALS INC	Reduce 31.00%	−1,132,028	−0.87
≡	INTRA-CELLULAR THERAPIES INC	Reduce 39.00%	−501,970	0.71
≡	VKTX – VIKING THERAPEUTICS INC	Reduce 49.00%	−486,889	−0.66
≡	PRCT – PROCEPT BIOROBOTICS CORP	Sell	−290,659	−0.64
≡	NTRA – NATERA INC	Sell	−125,000	−0.54
≡	ACLX – ARCELLX INC	Reduce 16.00%	−552,410	−0.53
≡	PTGX – PROTAGONIST THERAPEUTICS INC	Reduce 14.00%	−180,391	0.52
≡	PEN – PENUMBRA INC	Sell	−73,338	−0.47
≡	SEPN – SEPTERNA INC	Sell	−750,000	−0.47
≡	VRDN – VIRIDIAN THERAPEUTICS INC	Reduce 56.00%	−826,846	−0.46
≡	ORKA – ORUKA THERAPEUTICS INC	Sell	−845,567	−0.45
≡	ARVN – ARVINAS INC	Sell	−740,749	−0.39
≡	CGON – CG ONCOLOGY INC	Sell	−419,450	−0.33
≡	SYRE – SPYRE THERAPEUTICS INC	Reduce 10.00%	−261,451	−0.32
≡	EW – EDWARDS LIFESCIENCES CORP	Sell	−145,000	−0.29
≡	TARS – TARSUS PHARMACEUTICALS INC	Sell	−186,662	−0.28
≡	CRNX – CRINETICS PHARMACEUTICALS IN	Sell	−184,525	−0.26
≡	INARI MED INC	Sell	−178,797	−0.25
≡	AKERO THERAPEUTICS INC	Reduce 33.00%	−392,632	0.23
≡	EOLS – EVOLUS INC	Reduce 20.00%	−1,016,704	0.20
≡	ISRG – INTUITIVE SURGICAL INC	Reduce 36.00%	−22,500	−0.19
≡	ZBIO – ZENAS BIOPHARMA INC	Sell	−744,035	−0.17
≡	IRTC – IRHYTHM TECHNOLOGIES INC	Sell	−65,153	−0.16
≡	RAPP – RAPPORT THERAPEUTICS INC	Sell	−311,551	−0.15
≡	CBLL – CERIBELL INC	Sell	−180,546	−0.13
≡	VERU – VERU INC	Sell	−6,483,157	−0.11
≡	ARGX – ARGENX SE	Reduce 12.00%	−7,961	0.11
≡	CATX – PERSPECTIVE THERAPEUTICS INC	Sell	−1,190,263	−0.10
≡	LCTX – LINEAGE CELL THERAPEUTICS IN	Sell	−7,236,843	−0.10
≡	RCKT – ROCKET PHARMACEUTICALS INC	Reduce 63.00%	−237,858	−0.10
≡	PEPG – PEPGEN INC	Sell	−829,536	−0.09
≡	IBRX – IMMUNITYBIO INC	Sell	−1,221,734	−0.09
≡	AXSM – AXSOME THERAPEUTICS INC	Reduce 47.00%	−308,967	−0.08
≡	BCYC – BICYCLE THERAPEUTICS PLC	Sell	−197,108	−0.08
≡	AMICUS THERAPEUTICS INC	Reduce 11.00%	−2,781,425	−0.07
≡	ZYME – ZYMEWORKS INC	Reduce 12.00%	−265,348	−0.07
≡	RAPT THERAPEUTICS INC	Reduce 25.00%	−1,461,053	−0.06
≡	VRCA – VERRICA PHARMACEUTICALS INC	Sell	−3,249,669	−0.06
≡	FBRX – FORTE BIOSCIENCES INC	Sell	−95,742	−0.06
≡	NRIX – NURIX THERAPEUTICS INC	Reduce 10.00%	−33,061	−0.05
≡	TRIB – TRINITY BIOTECH PLC	Sell	−1,790,000	−0.04
≡	MREO – MEREO BIOPHARMA GROUP PLC	Reduce 19.00%	−208,551	−0.03
≡	FULC – FULCRUM THERAPEUTICS INC	Sell	−238,000	−0.03
≡	NVAXPUT – NOVAVAX INC	Sell	−100,000	−0.02
≡	OCUL – OCULAR THERAPEUTIX INC	Reduce 15.00%	−162,720	−0.02
≡	HLXC – HELIX ACQUISITION CORP II	Reduce 20.00%	−102,000	0.01
≡	PYXS – PYXIS ONCOLOGY INC	Sell	−188,462	−0.01
≡	NBTX – NANOBIOTIX	Reduce 61.00%	−161,040	−0.01

Hist	Stock	Activity	Share change	% change to portfolio
Q1 2026filed May 15, 2620 new17 added22 reduced42 exited
≡	XBIPUT – SPDR SERIES TRUST	Sell	−1,100,000	−2.39
≡	EXAS – EXACT SCIENCES CORP	Sell	−1,200,487	−2.17
≡	ACLX – ARCELLX INC	Sell	−1,466,071	−1.70
≡	BSX – BOSTON SCIENTIFIC CORP	Sell	−979,000	−1.66
≡	AMICUS THERAPEUTICS INC	Sell	−6,370,851	−1.62
≡	ASTRIA THERAPEUTICS INC	Sell	−6,485,420	−1.51
≡	VRDN – VIRIDIAN THERAPEUTICS INC	Reduce 62.00%	−1,871,874	−1.24
≡	RYTM – RHYTHM PHARMACEUTICALS INC	Reduce 7.00%	−172,596	−0.82
≡	DHR – DANAHER CORPORATION	Sell	−200,000	−0.82
≡	BLTE – BELITE BIO INC	Reduce 63.00%	−262,260	−0.71
≡	NBIX – NEUROCRINE BIOSCIENCES INC	Reduce 80.00%	−266,000	−0.67
≡	CDTX – CIDARA THERAPEUTICS INC	Sell	−165,131	−0.65
≡	IRON – DISC MEDICINE INC	Sell	−450,743	−0.64
≡	PEN – PENUMBRA INC	Sell	−110,529	−0.61
≡	APGE – APOGEE THERAPEUTICS INC	Reduce 34.00%	−790,267	−0.60
≡	CAI – CARIS LIFE SCIENCES INC	Sell	−1,136,206	−0.55
≡	RAPT THERAPEUTICS INC	Sell	−825,890	−0.50
≡	PVLA – PALVELLA THERAPEUTICS INC NE	Sell	−266,287	−0.50
≡	OMDA – OMADA HEALTH INC	Reduce 67.00%	−1,610,000	−0.48
≡	PTGX – PROTAGONIST THERAPEUTICS INC	Reduce 9.00%	−119,546	0.44
≡	KOD – KODIAK SCIENCES INC	Sell	−848,900	−0.42
≡	BIIB – BIOGEN INC	Sell	−124,000	−0.39
≡	ALDX – ALDEYRA THERAPEUTICS INC	Sell	−4,185,632	−0.39
≡	ABVX – ABIVAX SA	Reduce 28.00%	−129,459	−0.39
≡	MIRM – MIRUM PHARMACEUTICALS INC	Sell	−259,545	−0.37
≡	GRAL – GRAIL INC	Sell	−237,342	−0.36
≡	SION – SIONNA THERAPEUTICS INC	Reduce 44.00%	−520,659	−0.35
≡	CVS – CVS HEALTH CORP	Sell	−220,000	−0.31
≡	GKOS – GLAUKOS CORP	Sell	−140,000	−0.28
≡	RGEN – REPLIGEN CORP	Reduce 11.00%	−35,000	−0.27
≡	DXCM – DEXCOM INC	Sell	−225,758	−0.27
≡	SVRA – SAVARA INC	Sell	−2,400,000	−0.26
≡	SEPN – SEPTERNA INC	Sell	−433,160	−0.22
≡	ADMA – ADMA BIOLOGICS INC	Reduce 47.00%	−416,235	−0.20
≡	PALI – PALISADE BIO INC	Reduce 26.00%	−3,121,851	−0.20
≡	GOSS – GOSSAMER BIO INC	Sell	−3,139,669	−0.17
≡	MPLT – MAPLIGHT THERAPEUTICS INC	Sell	−550,000	−0.17
≡	XENE – XENON PHARMACEUTICALS INC	Sell	−200,791	−0.16
≡	KMTS – KESTRA MED TECHNOLOGIES LTD	Sell	−285,000	−0.13
≡	IMVT – IMMUNOVANT INC	Reduce 20.00%	−397,507	−0.13
≡	CAPRCALL – CAPRICOR THERAPEUTICS INC	Sell	−242,100	−0.12
≡	IKT – INHIBIKASE THERAPEUTICS INC	Reduce 57.00%	−3,106,568	−0.12
≡	BHVNCALL – BIOHAVEN LTD	Sell	−500,000	−0.10
≡	ADGM – ADAGIO MED HLDGS INC	Reduce 62.00%	−6,095,746	−0.10
≡	KYMR – KYMERA THERAPEUTICS INC	Sell	−69,935	−0.10
≡	PEPG – PEPGEN INC	Sell	−829,870	−0.10
≡	TECXCALL – TECTONIC THERAPEUTIC INC	Sell	−250,000	−0.09
≡	AQST – AQUESTIVE THERAPEUTICS INC	Sell	−747,193	−0.09
≡	DRUG – BRIGHT MINDS BIOSCIENCES INC	Reduce 16.00%	−71,746	−0.09
≡	KRYS – KRYSTAL BIOTECH INC	Sell	−17,500	−0.08
≡	OLMA – OLEMA PHARMACEUTICALS INC	Sell	−165,713	−0.07
≡	SDGR – SCHRODINGER INC	Sell	−202,400	−0.06
≡	IMMX – IMMIX BIOPHARMA INC	Sell	−338,941	−0.03
≡	LXEO – LEXEO THERAPEUTICS INC	Sell	−139,835	−0.02
≡	CTNM – CONTINEUM THERAPEUTICS INC	Reduce 14.00%	−209,000	0.02
≡	CBIO – CRESCENT BIOPHARMA INC.	Reduce 54.00%	−246,744	−0.02
≡	LENZ – LENZ THERAPEUTICS INC	Sell	−50,000	−0.01
≡	BDSX – BIODESIX	Sell	−108,694	−0.01
≡	CPIX – CUMBERLAND PHARMACEUTICALS I	Reduce 42.00%	−144,109	−0.01
≡	NVNO – ENVVENO MEDICAL CORPORATION	Sell	−1,759,035	−0.01
≡	IRD – OPUS GENETICS INC	Reduce 58.00%	−2,489,158	0.01
≡	IOVA – IOVANCE BIOTHERAPEUTICS INC	Sell	−152,714	−0.01
≡	AXGN – AXOGEN INC	Reduce 11.00%	−86,828	−0.01
≡	PTN – PALATIN TECHNOLOGIES INC	Reduce 12.00%	−8,055	0.00
Q4 2025filed Feb 17, 2641 new31 added17 reduced15 exited
≡	ACLX – ARCELLX INC	Reduce 41.00%	−1,002,282	−4.02
≡	MERUS N V	Sell	−1,353,093	−3.60
≡	INSM – INSMED INC	Sell	−702,130	−2.86
≡	AMLX – AMYLYX PHARMACEUTICALS INC	Reduce 7.00%	−667,483	−1.65
≡	VRNA – VERONA PHARMA PLC	Sell	−524,088	−1.58
≡	AKERO THERAPEUTICS INC	Sell	−1,135,766	−1.52
≡	MGTX – MEIRAGTX HLDGS PLC	Reduce 18.00%	−2,300,000	−1.47
≡	AORT – ARTIVION INC	Reduce 15.00%	−297,710	−1.02
≡	PEN – PENUMBRA INC	Reduce 50.00%	−110,018	−0.97
≡	NBIX – NEUROCRINE BIOSCIENCES INC	Reduce 26.00%	−119,000	−0.95
≡	CNTA – CENTESSA PHARMACEUTICALS PLC	Reduce 6.00%	−183,268	−0.82
≡	AQST – AQUESTIVE THERAPEUTICS INC	Reduce 80.00%	−3,012,906	−0.51
≡	ALDX – ALDEYRA THERAPEUTICS INC	Reduce 20.00%	−1,036,679	−0.38
≡	IRTC – IRHYTHM TECHNOLOGIES INC	Reduce 12.00%	−15,000	−0.26
≡	CRVS – CORVUS PHARMACEUTICALS INC	Reduce 52.00%	−746,154	−0.20
≡	PVLA – PALVELLA THERAPEUTICS INC NE	Reduce 33.00%	−128,806	−0.20
≡	JANX – JANUX THERAPEUTICS INC	Sell	−292,686	−0.20
≡	TEM – TEMPUS AI INC	Sell	−85,000	−0.19
≡	ADMA – ADMA BIOLOGICS INC	Reduce 23.00%	−270,000	−0.19
≡	KYMR – KYMERA THERAPEUTICS INC	Reduce 59.00%	−99,861	−0.17
≡	HTFL – HEARTFLOW INC	Sell	−150,000	−0.14
≡	GOSS – GOSSAMER BIO INC	Reduce 18.00%	−673,128	−0.11
≡	KRYS – KRYSTAL BIOTECH INC	Reduce 50.00%	−17,500	−0.10
≡	SCPHARMACEUTICALS INC	Sell	−583,142	−0.09
≡	VKTX – VIKING THERAPEUTICS INC	Sell	−105,597	−0.08
≡	PYXS – PYXIS ONCOLOGY INC	Sell	−1,178,307	−0.07
≡	SEPN – SEPTERNA INC	Reduce 20.00%	−108,290	−0.07
≡	SPRYPUT – ARS PHARMACEUTICALS INC	Sell	−200,000	−0.06
≡	TRIB – TRINITY BIOTECH PLC	Sell	−1,790,000	−0.05
≡	LYRA – LYRA THERAPEUTICS INC	Sell	−229,382	−0.04
≡	QURE – UNIQURE NV	Sell	−20,000	−0.03
≡	APYX – APYX MEDICAL CORPORATION	Sell	−150,000	−0.01
Q3 2025filed Nov 14, 2521 new28 added14 reduced13 exited
≡	VRNA – VERONA PHARMA PLC	Reduce 90.00%	−4,983,503	−17.25
≡	RYTM – RHYTHM PHARMACEUTICALS INC	Reduce 100.00%	−2,418,299	−4.34
≡	SLNO – SOLENO THERAPEUTICS INC	Sell	−430,439	−1.30
≡	XBIPUT – SPDR SERIES TRUST	Sell	−300,000	−0.90
≡	EOLS – EVOLUS INC	Sell	−2,474,843	−0.82
≡	AORT – ARTIVION INC	Reduce 28.00%	−773,703	−0.73
≡	PODD – INSULET CORP	Sell	−60,387	−0.69
≡	BBNX – BETA BIONICS INC	Reduce 83.00%	−1,315,664	−0.68
≡	DYN – DYNE THERAPEUTICS INC	Reduce 76.00%	−1,706,946	−0.58
≡	CRL – CHARLES RIV LABS INTL INC	Sell	−100,000	−0.55
≡	IMVT – IMMUNOVANT INC	Reduce 26.00%	−550,000	−0.51
≡	EWTX – EDGEWISE THERAPEUTICS INC	Reduce 18.00%	−844,055	−0.46
≡	ADMA – ADMA BIOLOGICS INC	Reduce 12.00%	−150,000	−0.38
≡	RARE – ULTRAGENYX PHARMACEUTICAL IN	Sell	−270,000	−0.35
≡	VKTX – VIKING THERAPEUTICS INC	Reduce 72.00%	−275,103	−0.29
≡	SYRE – SPYRE THERAPEUTICS INC	Reduce 20.00%	−300,000	−0.25
≡	AXSM – AXSOME THERAPEUTICS INC	Reduce 25.00%	−49,634	−0.24
≡	CAPRPUT – CAPRICOR THERAPEUTICS INC	Sell	−650,000	−0.23
≡	GMED – GLOBUS MED INC	Sell	−88,500	−0.19
≡	HLXC – HELIX ACQUISITION CORP II	Sell	−398,000	−0.15
≡	AMICUS THERAPEUTICS INC	Reduce 14.00%	−1,041,979	−0.12
≡	KYMR – KYMERA THERAPEUTICS INC	Reduce 19.00%	−40,310	−0.06
≡	LONA – ATHIRA PHARMA INC	Sell	−5,402,964	−0.06
≡	LYRA – LYRA THERAPEUTICS INC	Reduce 10.00%	−25,768	−0.04
≡	FBRX – FORTE BIOSCIENCES INC	Sell	−68,192	−0.03
≡	BDSX – BIODESIX INC	Sell	−2,173,880	−0.02
≡	KALA – KALA BIO INC	Sell	−55,227	−0.01
Q2 2025filed Aug 14, 2522 new8 added27 reduced23 exited
≡	AMICUS THERAPEUTICS INC	Reduce 65.00%	−14,051,697	−4.60
≡	VRNA – VERONA PHARMA PLC	Reduce 16.00%	−1,055,749	4.23
≡	INTRA-CELLULAR THERAPIES INC	Sell	−786,358	−3.64
≡	SLNO – SOLENO THERAPEUTICS INC	Reduce 71.00%	−1,076,163	−2.47
≡	IOVA – IOVANCE BIOTHERAPEUTICS INC	Sell	−12,711,788	−1.48
≡	ALDX – ALDEYRA THERAPEUTICS INC	Reduce 56.00%	−5,224,220	−1.31
≡	ARGX – ARGENX SE	Sell	−59,510	−1.23
≡	CNTA – CENTESSA PHARMACEUTICALS PLC	Reduce 62.00%	−1,893,460	−0.99
≡	PCVX – VAXCYTE INC	Sell	−706,567	−0.94
≡	EOLS – EVOLUS INC	Reduce 40.00%	−1,654,299	−0.92
≡	ACLX – ARCELLX INC	Reduce 15.00%	−448,478	−0.83
≡	AXSM – AXSOME THERAPEUTICS INC	Reduce 44.00%	−156,573	−0.70
≡	JANX – JANUX THERAPEUTICS INC	Reduce 70.00%	−677,726	−0.67
≡	MDGL – MADRIGAL PHARMACEUTICALS INC	Sell	−46,500	−0.54
≡	SYRE – SPYRE THERAPEUTICS INC	Reduce 34.00%	−783,827	−0.48
≡	IMVT – IMMUNOVANT INC	Reduce 25.00%	−706,182	−0.47
≡	DXCM – DEXCOM INC	Sell	−178,000	−0.43
≡	ACRV – ACRIVON THERAPEUTICS INC	Sell	−5,360,858	−0.38
≡	CRGX – CARGO THERAPEUTICS INC	Sell	−2,431,085	−0.35
≡	EYPT – EYEPOINT PHARMACEUTICALS INC	Sell	−1,537,274	−0.29
≡	NUVL – NUVALENT INC	Reduce 16.00%	−258,788	−0.27
≡	IRON – DISC MEDICINE INC	Sell	−150,000	−0.26
≡	CTNM – CONTINEUM THERAPEUTICS INC	Reduce 51.00%	−741,763	−0.25
≡	ADPT – ADAPTIVE BIOTECHNOLOGIES COR	Sell	−930,972	−0.24
≡	OCUL – OCULAR THERAPEUTIX INC	Sell	−915,775	−0.24
≡	DCTH – DELCATH SYS INC	Sell	−462,422	−0.21
≡	ZYME – ZYMEWORKS INC	Reduce 32.00%	−589,398	−0.20
≡	RAPT THERAPEUTICS INC	Sell	−4,418,947	−0.19
≡	KMTS – KESTRA MED TECHNOLOGIES LTD	Sell	−200,000	−0.17
≡	PRAX – PRAXIS PRECISION MEDICINES I	Reduce 23.00%	−227,973	−0.16
≡	XENE – XENON PHARMACEUTICALS INC	Reduce 38.00%	−124,533	−0.16
≡	OKUR – ONKURE THERAPEUTICS INC	Sell	−1,004,439	−0.15
≡	AVTX – AVALO THERAPEUTICS INC	Reduce 73.00%	−380,333	−0.12
≡	AQST – AQUESTIVE THERAPEUTICS INC	Reduce 41.00%	−1,536,788	−0.12
≡	BBNX – BETA BIONICS INC	Reduce 28.00%	−610,232	−0.11
≡	VRDN – VIRIDIAN THERAPEUTICS INC	Reduce 32.00%	−212,155	−0.09
≡	IKT – INHIBIKASE THERAPEUTICS INC	Reduce 8.00%	−492,707	−0.07
≡	MREO – MEREO BIOPHARMA GROUP PLC	Sell	−876,961	−0.07
≡	VKTX – VIKING THERAPEUTICS INC	Reduce 25.00%	−128,305	−0.07
≡	LYRA – LYRA THERAPEUTICS INC	Sell	−12,757,562	−0.06
≡	CELC – CELCUITY INC	Reduce 31.00%	−729,071	−0.05
≡	KALA – KALA BIO INC	Reduce 80.00%	−222,383	−0.05
≡	AVR – ANTERIS TECHNOLOGIES GLOBAL	Reduce 20.00%	−434,870	−0.04
≡	TRAW – TRAWS PHARMA INC	Sell	−421,781	−0.03
≡	RCKT – ROCKET PHARMACEUTICALS INC	Sell	−140,726	−0.03
≡	PODD – INSULET CORP	Reduce 16.00%	−11,210	0.03
≡	CGEM – CULLINAN THERAPEUTICS INC	Sell	−80,100	−0.02
≡	INBX – INHIBRX BIOSCIENCES INC	Reduce 8.00%	−86,134	−0.02
≡	APPLIED THERAPEUTICS INC	Sell	−860,000	−0.01
≡	NBTX – NANOBIOTIX	Sell	−105,053	−0.01
Q1 2025filed May 15, 2515 new13 added29 reduced27 exited
≡	IOVA – IOVANCE BIOTHERAPEUTICS INC	Reduce 43.00%	−9,400,478	−2.97
≡	PCVX – VAXCYTE INC	Reduce 59.00%	−1,011,850	−2.89
≡	EWTXCALL – EDGEWISE THERAPEUTICS INC	Reduce 81.00%	−2,185,537	−1.56
≡	NUVL – NUVALENT INC	Reduce 38.00%	−986,009	−1.52
≡	PRAX – PRAXIS PRECISION MEDICINES I	Reduce 26.00%	−348,841	−1.48
≡	CNTA – CENTESSA PHARMACEUTICALS PLC	Reduce 52.00%	−3,308,825	−1.36
≡	CRGX – CARGO THERAPEUTICS INC	Reduce 34.00%	−1,251,919	−1.10
≡	PODD – INSULET CORP	Reduce 69.00%	−160,672	−0.99
≡	RYTM – RHYTHM PHARMACEUTICALS INC	Reduce 31.00%	−1,132,028	−0.87
≡	INTRA-CELLULAR THERAPIES INC	Reduce 39.00%	−501,970	0.71
≡	VKTX – VIKING THERAPEUTICS INC	Reduce 49.00%	−486,889	−0.66
≡	PRCT – PROCEPT BIOROBOTICS CORP	Sell	−290,659	−0.64
≡	NTRA – NATERA INC	Sell	−125,000	−0.54
≡	ACLX – ARCELLX INC	Reduce 16.00%	−552,410	−0.53
≡	PTGX – PROTAGONIST THERAPEUTICS INC	Reduce 14.00%	−180,391	0.52
≡	PEN – PENUMBRA INC	Sell	−73,338	−0.47
≡	SEPN – SEPTERNA INC	Sell	−750,000	−0.47
≡	VRDN – VIRIDIAN THERAPEUTICS INC	Reduce 56.00%	−826,846	−0.46
≡	ORKA – ORUKA THERAPEUTICS INC	Sell	−845,567	−0.45
≡	ARVN – ARVINAS INC	Sell	−740,749	−0.39
≡	CGON – CG ONCOLOGY INC	Sell	−419,450	−0.33
≡	SYRE – SPYRE THERAPEUTICS INC	Reduce 10.00%	−261,451	−0.32
≡	EW – EDWARDS LIFESCIENCES CORP	Sell	−145,000	−0.29
≡	TARS – TARSUS PHARMACEUTICALS INC	Sell	−186,662	−0.28
≡	CRNX – CRINETICS PHARMACEUTICALS IN	Sell	−184,525	−0.26
≡	INARI MED INC	Sell	−178,797	−0.25
≡	AKERO THERAPEUTICS INC	Reduce 33.00%	−392,632	0.23
≡	EOLS – EVOLUS INC	Reduce 20.00%	−1,016,704	0.20
≡	ISRG – INTUITIVE SURGICAL INC	Reduce 36.00%	−22,500	−0.19
≡	ZBIO – ZENAS BIOPHARMA INC	Sell	−744,035	−0.17
≡	IRTC – IRHYTHM TECHNOLOGIES INC	Sell	−65,153	−0.16
≡	RAPP – RAPPORT THERAPEUTICS INC	Sell	−311,551	−0.15
≡	CBLL – CERIBELL INC	Sell	−180,546	−0.13
≡	VERU – VERU INC	Sell	−6,483,157	−0.11
≡	ARGX – ARGENX SE	Reduce 12.00%	−7,961	0.11
≡	CATX – PERSPECTIVE THERAPEUTICS INC	Sell	−1,190,263	−0.10
≡	LCTX – LINEAGE CELL THERAPEUTICS IN	Sell	−7,236,843	−0.10
≡	RCKT – ROCKET PHARMACEUTICALS INC	Reduce 63.00%	−237,858	−0.10
≡	PEPG – PEPGEN INC	Sell	−829,536	−0.09
≡	IBRX – IMMUNITYBIO INC	Sell	−1,221,734	−0.09
≡	AXSM – AXSOME THERAPEUTICS INC	Reduce 47.00%	−308,967	−0.08
≡	BCYC – BICYCLE THERAPEUTICS PLC	Sell	−197,108	−0.08
≡	AMICUS THERAPEUTICS INC	Reduce 11.00%	−2,781,425	−0.07
≡	ZYME – ZYMEWORKS INC	Reduce 12.00%	−265,348	−0.07
≡	RAPT THERAPEUTICS INC	Reduce 25.00%	−1,461,053	−0.06
≡	VRCA – VERRICA PHARMACEUTICALS INC	Sell	−3,249,669	−0.06
≡	FBRX – FORTE BIOSCIENCES INC	Sell	−95,742	−0.06
≡	NRIX – NURIX THERAPEUTICS INC	Reduce 10.00%	−33,061	−0.05
≡	TRIB – TRINITY BIOTECH PLC	Sell	−1,790,000	−0.04
≡	MREO – MEREO BIOPHARMA GROUP PLC	Reduce 19.00%	−208,551	−0.03
≡	FULC – FULCRUM THERAPEUTICS INC	Sell	−238,000	−0.03
≡	NVAXPUT – NOVAVAX INC	Sell	−100,000	−0.02
≡	OCUL – OCULAR THERAPEUTIX INC	Reduce 15.00%	−162,720	−0.02
≡	HLXC – HELIX ACQUISITION CORP II	Reduce 20.00%	−102,000	0.01
≡	PYXS – PYXIS ONCOLOGY INC	Sell	−188,462	−0.01
≡	NBTX – NANOBIOTIX	Reduce 61.00%	−161,040	−0.01

Hist

Stock

Activity

Share change

% change to portfolio

Q1 2026filed May 15, 2620 new17 added22 reduced42 exited

≡

XBIPUT – SPDR SERIES TRUST

Sell

−1,100,000

−2.39

≡

EXAS – EXACT SCIENCES CORP

Sell

−1,200,487

−2.17

≡

ACLX – ARCELLX INC

Sell

−1,466,071

−1.70

≡

BSX – BOSTON SCIENTIFIC CORP

Sell

−979,000

−1.66

≡

AMICUS THERAPEUTICS INC

Sell

−6,370,851

−1.62

≡

ASTRIA THERAPEUTICS INC

Sell

−6,485,420

−1.51

≡

VRDN – VIRIDIAN THERAPEUTICS INC

Reduce 62.00%

−1,871,874

−1.24

≡

RYTM – RHYTHM PHARMACEUTICALS INC

Reduce 7.00%

−172,596

−0.82

≡

DHR – DANAHER CORPORATION

Sell

−200,000

−0.82

≡

BLTE – BELITE BIO INC

Reduce 63.00%

−262,260

−0.71

≡

NBIX – NEUROCRINE BIOSCIENCES INC

Reduce 80.00%

−266,000

−0.67

≡

CDTX – CIDARA THERAPEUTICS INC

Sell

−165,131

−0.65

≡

IRON – DISC MEDICINE INC

Sell

−450,743

−0.64

≡

PEN – PENUMBRA INC

Sell

−110,529

−0.61

≡

APGE – APOGEE THERAPEUTICS INC

Reduce 34.00%

−790,267

−0.60

≡

CAI – CARIS LIFE SCIENCES INC

Sell

−1,136,206

−0.55

≡

RAPT THERAPEUTICS INC

Sell

−825,890

−0.50

≡

PVLA – PALVELLA THERAPEUTICS INC NE

Sell

−266,287

−0.50

≡

OMDA – OMADA HEALTH INC

Reduce 67.00%

−1,610,000

−0.48

≡

PTGX – PROTAGONIST THERAPEUTICS INC

Reduce 9.00%

−119,546

0.44

≡

KOD – KODIAK SCIENCES INC

Sell

−848,900

−0.42

≡

BIIB – BIOGEN INC

Sell

−124,000

−0.39

≡

ALDX – ALDEYRA THERAPEUTICS INC

Sell

−4,185,632

−0.39

≡

ABVX – ABIVAX SA

Reduce 28.00%

−129,459

−0.39

≡

MIRM – MIRUM PHARMACEUTICALS INC

Sell

−259,545

−0.37

≡

GRAL – GRAIL INC

Sell

−237,342

−0.36

≡

SION – SIONNA THERAPEUTICS INC

Reduce 44.00%

−520,659

−0.35

≡

CVS – CVS HEALTH CORP

Sell

−220,000

−0.31

≡

GKOS – GLAUKOS CORP

Sell

−140,000

−0.28

≡

RGEN – REPLIGEN CORP

Reduce 11.00%

−35,000

−0.27

≡

DXCM – DEXCOM INC

Sell

−225,758

−0.27

≡

SVRA – SAVARA INC

Sell

−2,400,000

−0.26

≡

SEPN – SEPTERNA INC

Sell

−433,160

−0.22

≡

ADMA – ADMA BIOLOGICS INC

Reduce 47.00%

−416,235

−0.20

≡

PALI – PALISADE BIO INC

Reduce 26.00%

−3,121,851

−0.20

≡

GOSS – GOSSAMER BIO INC

Sell

−3,139,669

−0.17

≡

MPLT – MAPLIGHT THERAPEUTICS INC

Sell

−550,000

−0.17

≡

XENE – XENON PHARMACEUTICALS INC

Sell

−200,791

−0.16

≡

KMTS – KESTRA MED TECHNOLOGIES LTD

Sell

−285,000

−0.13

≡

IMVT – IMMUNOVANT INC

Reduce 20.00%

−397,507

−0.13

≡

CAPRCALL – CAPRICOR THERAPEUTICS INC

Sell

−242,100

−0.12

≡

IKT – INHIBIKASE THERAPEUTICS INC

Reduce 57.00%

−3,106,568

−0.12

≡

BHVNCALL – BIOHAVEN LTD

Sell

−500,000

−0.10

≡

ADGM – ADAGIO MED HLDGS INC

Reduce 62.00%

−6,095,746

−0.10

≡

KYMR – KYMERA THERAPEUTICS INC

Sell

−69,935

−0.10

≡

PEPG – PEPGEN INC

Sell

−829,870

−0.10

≡

TECXCALL – TECTONIC THERAPEUTIC INC

Sell

−250,000

−0.09

≡

AQST – AQUESTIVE THERAPEUTICS INC

Sell

−747,193

−0.09

≡

DRUG – BRIGHT MINDS BIOSCIENCES INC

Reduce 16.00%

−71,746

−0.09

≡

KRYS – KRYSTAL BIOTECH INC

Sell

−17,500

−0.08

≡

OLMA – OLEMA PHARMACEUTICALS INC

Sell

−165,713

−0.07

≡

SDGR – SCHRODINGER INC

Sell

−202,400

−0.06

≡

IMMX – IMMIX BIOPHARMA INC

Sell

−338,941

−0.03

≡

LXEO – LEXEO THERAPEUTICS INC

Sell

−139,835

−0.02

≡

CTNM – CONTINEUM THERAPEUTICS INC

Reduce 14.00%

−209,000

0.02

≡

CBIO – CRESCENT BIOPHARMA INC.

Reduce 54.00%

−246,744

−0.02

≡

LENZ – LENZ THERAPEUTICS INC

Sell

−50,000

−0.01

≡

BDSX – BIODESIX

Sell

−108,694

−0.01

≡

CPIX – CUMBERLAND PHARMACEUTICALS I

Reduce 42.00%

−144,109

−0.01

≡

NVNO – ENVVENO MEDICAL CORPORATION

Sell

−1,759,035

−0.01

≡

IRD – OPUS GENETICS INC

Reduce 58.00%

−2,489,158

0.01

≡

IOVA – IOVANCE BIOTHERAPEUTICS INC

Sell

−152,714

−0.01

≡

AXGN – AXOGEN INC

Reduce 11.00%

−86,828

−0.01

≡

PTN – PALATIN TECHNOLOGIES INC

Reduce 12.00%

−8,055

0.00

Q4 2025filed Feb 17, 2641 new31 added17 reduced15 exited

≡

ACLX – ARCELLX INC

Reduce 41.00%

−1,002,282

−4.02

≡

MERUS N V

Sell

−1,353,093

−3.60

≡

INSM – INSMED INC

Sell

−702,130

−2.86

≡

AMLX – AMYLYX PHARMACEUTICALS INC

Reduce 7.00%

−667,483

−1.65

≡

VRNA – VERONA PHARMA PLC

Sell

−524,088

−1.58

≡

AKERO THERAPEUTICS INC

Sell

−1,135,766

−1.52

≡

MGTX – MEIRAGTX HLDGS PLC

Reduce 18.00%

−2,300,000

−1.47

≡

AORT – ARTIVION INC

Reduce 15.00%

−297,710

−1.02

≡

PEN – PENUMBRA INC

Reduce 50.00%

−110,018

−0.97

≡

NBIX – NEUROCRINE BIOSCIENCES INC

Reduce 26.00%

−119,000

−0.95

≡

CNTA – CENTESSA PHARMACEUTICALS PLC

Reduce 6.00%

−183,268

−0.82

≡

AQST – AQUESTIVE THERAPEUTICS INC

Reduce 80.00%

−3,012,906

−0.51

≡

ALDX – ALDEYRA THERAPEUTICS INC

Reduce 20.00%

−1,036,679

−0.38

≡

IRTC – IRHYTHM TECHNOLOGIES INC

Reduce 12.00%

−15,000

−0.26

≡

CRVS – CORVUS PHARMACEUTICALS INC

Reduce 52.00%

−746,154

−0.20

≡

PVLA – PALVELLA THERAPEUTICS INC NE

Reduce 33.00%

−128,806

−0.20

≡

JANX – JANUX THERAPEUTICS INC

Sell

−292,686

−0.20

≡

TEM – TEMPUS AI INC

Sell

−85,000

−0.19

≡

ADMA – ADMA BIOLOGICS INC

Reduce 23.00%

−270,000

−0.19

≡

KYMR – KYMERA THERAPEUTICS INC

Reduce 59.00%

−99,861

−0.17

≡

HTFL – HEARTFLOW INC

Sell

−150,000

−0.14

≡

GOSS – GOSSAMER BIO INC

Reduce 18.00%

−673,128

−0.11

≡

KRYS – KRYSTAL BIOTECH INC

Reduce 50.00%

−17,500

−0.10

≡

SCPHARMACEUTICALS INC

Sell

−583,142

−0.09

≡

VKTX – VIKING THERAPEUTICS INC

Sell

−105,597

−0.08

≡

PYXS – PYXIS ONCOLOGY INC

Sell

−1,178,307

−0.07

≡

SEPN – SEPTERNA INC

Reduce 20.00%

−108,290

−0.07

≡

SPRYPUT – ARS PHARMACEUTICALS INC

Sell

−200,000

−0.06

≡

TRIB – TRINITY BIOTECH PLC

Sell

−1,790,000

−0.05

≡

LYRA – LYRA THERAPEUTICS INC

Sell

−229,382

−0.04

≡

QURE – UNIQURE NV

Sell

−20,000

−0.03

≡

APYX – APYX MEDICAL CORPORATION

Sell

−150,000

−0.01

Q3 2025filed Nov 14, 2521 new28 added14 reduced13 exited

≡

VRNA – VERONA PHARMA PLC

Reduce 90.00%

−4,983,503

−17.25

≡

RYTM – RHYTHM PHARMACEUTICALS INC

Reduce 100.00%

−2,418,299

−4.34

≡

SLNO – SOLENO THERAPEUTICS INC

Sell

−430,439

−1.30

≡

XBIPUT – SPDR SERIES TRUST

Sell

−300,000

−0.90

≡

EOLS – EVOLUS INC

Sell

−2,474,843

−0.82

≡

AORT – ARTIVION INC

Reduce 28.00%

−773,703

−0.73

≡

PODD – INSULET CORP

Sell

−60,387

−0.69

≡

BBNX – BETA BIONICS INC

Reduce 83.00%

−1,315,664

−0.68

≡

DYN – DYNE THERAPEUTICS INC

Reduce 76.00%

−1,706,946

−0.58

≡

CRL – CHARLES RIV LABS INTL INC

Sell

−100,000

−0.55

≡

IMVT – IMMUNOVANT INC

Reduce 26.00%

−550,000

−0.51

≡

EWTX – EDGEWISE THERAPEUTICS INC

Reduce 18.00%

−844,055

−0.46

≡

ADMA – ADMA BIOLOGICS INC

Reduce 12.00%

−150,000

−0.38

≡

RARE – ULTRAGENYX PHARMACEUTICAL IN

Sell

−270,000

−0.35

≡

VKTX – VIKING THERAPEUTICS INC

Reduce 72.00%

−275,103

−0.29

≡

SYRE – SPYRE THERAPEUTICS INC

Reduce 20.00%

−300,000

−0.25

≡

AXSM – AXSOME THERAPEUTICS INC

Reduce 25.00%

−49,634

−0.24

≡

CAPRPUT – CAPRICOR THERAPEUTICS INC

Sell

−650,000

−0.23

≡

GMED – GLOBUS MED INC

Sell

−88,500

−0.19

≡

HLXC – HELIX ACQUISITION CORP II

Sell

−398,000

−0.15

≡

AMICUS THERAPEUTICS INC

Reduce 14.00%

−1,041,979

−0.12

≡

KYMR – KYMERA THERAPEUTICS INC

Reduce 19.00%

−40,310

−0.06

≡

LONA – ATHIRA PHARMA INC

Sell

−5,402,964

−0.06

≡

LYRA – LYRA THERAPEUTICS INC

Reduce 10.00%

−25,768

−0.04

≡

FBRX – FORTE BIOSCIENCES INC

Sell

−68,192

−0.03

≡

BDSX – BIODESIX INC

Sell

−2,173,880

−0.02

≡

KALA – KALA BIO INC

Sell

−55,227

−0.01

Q2 2025filed Aug 14, 2522 new8 added27 reduced23 exited

≡

AMICUS THERAPEUTICS INC

Reduce 65.00%

−14,051,697

−4.60

≡

VRNA – VERONA PHARMA PLC

Reduce 16.00%

−1,055,749

4.23

≡

INTRA-CELLULAR THERAPIES INC

Sell

−786,358

−3.64

≡

SLNO – SOLENO THERAPEUTICS INC

Reduce 71.00%

−1,076,163

−2.47

≡

IOVA – IOVANCE BIOTHERAPEUTICS INC

Sell

−12,711,788

−1.48

≡

ALDX – ALDEYRA THERAPEUTICS INC

Reduce 56.00%

−5,224,220

−1.31

≡

ARGX – ARGENX SE

Sell

−59,510

−1.23

≡

CNTA – CENTESSA PHARMACEUTICALS PLC

Reduce 62.00%

−1,893,460

−0.99

≡

PCVX – VAXCYTE INC

Sell

−706,567

−0.94

≡

EOLS – EVOLUS INC

Reduce 40.00%

−1,654,299

−0.92

≡

ACLX – ARCELLX INC

Reduce 15.00%

−448,478

−0.83

≡

AXSM – AXSOME THERAPEUTICS INC

Reduce 44.00%

−156,573

−0.70

≡

JANX – JANUX THERAPEUTICS INC

Reduce 70.00%

−677,726

−0.67

≡

MDGL – MADRIGAL PHARMACEUTICALS INC

Sell

−46,500

−0.54

≡

SYRE – SPYRE THERAPEUTICS INC

Reduce 34.00%

−783,827

−0.48

≡

IMVT – IMMUNOVANT INC

Reduce 25.00%

−706,182

−0.47

≡

DXCM – DEXCOM INC

Sell

−178,000

−0.43

≡

ACRV – ACRIVON THERAPEUTICS INC

Sell

−5,360,858

−0.38

≡

CRGX – CARGO THERAPEUTICS INC

Sell

−2,431,085

−0.35

≡

EYPT – EYEPOINT PHARMACEUTICALS INC

Sell

−1,537,274

−0.29

≡

NUVL – NUVALENT INC

Reduce 16.00%

−258,788

−0.27

≡

IRON – DISC MEDICINE INC

Sell

−150,000

−0.26

≡

CTNM – CONTINEUM THERAPEUTICS INC

Reduce 51.00%

−741,763

−0.25

≡

ADPT – ADAPTIVE BIOTECHNOLOGIES COR

Sell

−930,972

−0.24

≡

OCUL – OCULAR THERAPEUTIX INC

Sell

−915,775

−0.24

≡

DCTH – DELCATH SYS INC

Sell

−462,422

−0.21

≡

ZYME – ZYMEWORKS INC

Reduce 32.00%

−589,398

−0.20

≡

RAPT THERAPEUTICS INC

Sell

−4,418,947

−0.19

≡

KMTS – KESTRA MED TECHNOLOGIES LTD

Sell

−200,000

−0.17

≡

PRAX – PRAXIS PRECISION MEDICINES I

Reduce 23.00%

−227,973

−0.16

≡

XENE – XENON PHARMACEUTICALS INC

Reduce 38.00%

−124,533

−0.16

≡

OKUR – ONKURE THERAPEUTICS INC

Sell

−1,004,439

−0.15

≡

AVTX – AVALO THERAPEUTICS INC

Reduce 73.00%

−380,333

−0.12

≡

AQST – AQUESTIVE THERAPEUTICS INC

Reduce 41.00%

−1,536,788

−0.12

≡

BBNX – BETA BIONICS INC

Reduce 28.00%

−610,232

−0.11

≡

VRDN – VIRIDIAN THERAPEUTICS INC

Reduce 32.00%

−212,155

−0.09

≡

IKT – INHIBIKASE THERAPEUTICS INC

Reduce 8.00%

−492,707

−0.07

≡

MREO – MEREO BIOPHARMA GROUP PLC

Sell

−876,961

−0.07

≡

VKTX – VIKING THERAPEUTICS INC

Reduce 25.00%

−128,305

−0.07

≡

LYRA – LYRA THERAPEUTICS INC

Sell

−12,757,562

−0.06

≡

CELC – CELCUITY INC

Reduce 31.00%

−729,071

−0.05

≡

KALA – KALA BIO INC

Reduce 80.00%

−222,383

−0.05

≡

AVR – ANTERIS TECHNOLOGIES GLOBAL

Reduce 20.00%

−434,870

−0.04

≡

TRAW – TRAWS PHARMA INC

Sell

−421,781

−0.03

≡

RCKT – ROCKET PHARMACEUTICALS INC

Sell

−140,726

−0.03

≡

PODD – INSULET CORP

Reduce 16.00%

−11,210

0.03

≡

CGEM – CULLINAN THERAPEUTICS INC

Sell

−80,100

−0.02

≡

INBX – INHIBRX BIOSCIENCES INC

Reduce 8.00%

−86,134

−0.02

≡

APPLIED THERAPEUTICS INC

Sell

−860,000

−0.01

≡

NBTX – NANOBIOTIX

Sell

−105,053

−0.01

Q1 2025filed May 15, 2515 new13 added29 reduced27 exited

≡

IOVA – IOVANCE BIOTHERAPEUTICS INC

Reduce 43.00%

−9,400,478

−2.97

≡

PCVX – VAXCYTE INC

Reduce 59.00%

−1,011,850

−2.89

≡

EWTXCALL – EDGEWISE THERAPEUTICS INC

Reduce 81.00%

−2,185,537

−1.56

≡

NUVL – NUVALENT INC

Reduce 38.00%

−986,009

−1.52

≡

PRAX – PRAXIS PRECISION MEDICINES I

Reduce 26.00%

−348,841

−1.48

≡

CNTA – CENTESSA PHARMACEUTICALS PLC

Reduce 52.00%

−3,308,825

−1.36

≡

CRGX – CARGO THERAPEUTICS INC

Reduce 34.00%

−1,251,919

−1.10

≡

PODD – INSULET CORP

Reduce 69.00%

−160,672

−0.99

≡

RYTM – RHYTHM PHARMACEUTICALS INC

Reduce 31.00%

−1,132,028

−0.87

≡

INTRA-CELLULAR THERAPIES INC

Reduce 39.00%

−501,970

0.71

≡

VKTX – VIKING THERAPEUTICS INC

Reduce 49.00%

−486,889

−0.66

≡

PRCT – PROCEPT BIOROBOTICS CORP

Sell

−290,659

−0.64

≡

NTRA – NATERA INC

Sell

−125,000

−0.54

≡

ACLX – ARCELLX INC

Reduce 16.00%

−552,410

−0.53

≡

PTGX – PROTAGONIST THERAPEUTICS INC

Reduce 14.00%

−180,391

0.52

≡

PEN – PENUMBRA INC

Sell

−73,338

−0.47

≡

SEPN – SEPTERNA INC

Sell

−750,000

−0.47

≡

VRDN – VIRIDIAN THERAPEUTICS INC

Reduce 56.00%

−826,846

−0.46

≡

ORKA – ORUKA THERAPEUTICS INC

Sell

−845,567

−0.45

≡

ARVN – ARVINAS INC

Sell

−740,749

−0.39

≡

CGON – CG ONCOLOGY INC

Sell

−419,450

−0.33

≡

SYRE – SPYRE THERAPEUTICS INC

Reduce 10.00%

−261,451

−0.32

≡

EW – EDWARDS LIFESCIENCES CORP

Sell

−145,000

−0.29

≡

TARS – TARSUS PHARMACEUTICALS INC

Sell

−186,662

−0.28

≡

CRNX – CRINETICS PHARMACEUTICALS IN

Sell

−184,525

−0.26

≡

INARI MED INC

Sell

−178,797

−0.25

≡

AKERO THERAPEUTICS INC

Reduce 33.00%

−392,632

0.23

≡

EOLS – EVOLUS INC

Reduce 20.00%

−1,016,704

0.20

≡

ISRG – INTUITIVE SURGICAL INC

Reduce 36.00%

−22,500

−0.19

≡

ZBIO – ZENAS BIOPHARMA INC

Sell

−744,035

−0.17

≡

IRTC – IRHYTHM TECHNOLOGIES INC

Sell

−65,153

−0.16

≡

RAPP – RAPPORT THERAPEUTICS INC

Sell

−311,551

−0.15

≡

CBLL – CERIBELL INC

Sell

−180,546

−0.13

≡

VERU – VERU INC

Sell

−6,483,157

−0.11

≡

ARGX – ARGENX SE

Reduce 12.00%

−7,961

0.11

≡

CATX – PERSPECTIVE THERAPEUTICS INC

Sell

−1,190,263

−0.10

≡

LCTX – LINEAGE CELL THERAPEUTICS IN

Sell

−7,236,843

−0.10

≡

RCKT – ROCKET PHARMACEUTICALS INC

Reduce 63.00%

−237,858

−0.10

≡

PEPG – PEPGEN INC

Sell

−829,536

−0.09

≡

IBRX – IMMUNITYBIO INC

Sell

−1,221,734

−0.09

≡

AXSM – AXSOME THERAPEUTICS INC

Reduce 47.00%

−308,967

−0.08

≡

BCYC – BICYCLE THERAPEUTICS PLC

Sell

−197,108

−0.08

≡

AMICUS THERAPEUTICS INC

Reduce 11.00%

−2,781,425

−0.07

≡

ZYME – ZYMEWORKS INC

Reduce 12.00%

−265,348

−0.07

≡

RAPT THERAPEUTICS INC

Reduce 25.00%

−1,461,053

−0.06

≡

VRCA – VERRICA PHARMACEUTICALS INC

Sell

−3,249,669

−0.06

≡

FBRX – FORTE BIOSCIENCES INC

Sell

−95,742

−0.06

≡

NRIX – NURIX THERAPEUTICS INC

Reduce 10.00%

−33,061

−0.05

≡

TRIB – TRINITY BIOTECH PLC

Sell

−1,790,000

−0.04

≡

MREO – MEREO BIOPHARMA GROUP PLC

Reduce 19.00%

−208,551

−0.03

≡

FULC – FULCRUM THERAPEUTICS INC

Sell

−238,000

−0.03

≡

NVAXPUT – NOVAVAX INC

Sell

−100,000

−0.02

≡

OCUL – OCULAR THERAPEUTIX INC

Reduce 15.00%

−162,720

−0.02

≡

HLXC – HELIX ACQUISITION CORP II

Reduce 20.00%

−102,000

0.01

≡

PYXS – PYXIS ONCOLOGY INC

Sell

−188,462

−0.01

≡

NBTX – NANOBIOTIX

Reduce 61.00%

−161,040

−0.01