Perceptive Advisors LLC

Period:: Q1 2026
Portfolio date:: Mar 31, 2026
No. of stocks:: 91
Portfolio value:: $5,110,912,000
Filed:: May 15, 2026
CIK:: 1224962

Stock	Issuer	% of Portfolio	Recent Activity	Shares	Price	Value ▼
PRAX hist	PRAXIS PRECISION MEDICINES I	12.83	Add 2.00%	2,035,986	$322.19	$655.97M
CELC hist	CELCUITY INC	7.29	—	9,627,200	$38.73	$372.81M
ASND hist	ASCENDIS PHARMA A/S	6.85	Add 42.00%	1,531,421	$228.73	$350.28M
ROIV hist	ROIVANT SCIENCES LTD	4.49	Add 4.00%	8,285,461	$27.70	$229.51M
CNTA hist	CENTESSA PHARMACEUTICALS PLC	4.09	Add 80.00%	5,258,903	$39.72	$208.88M
RYTM hist	RHYTHM PHARMACEUTICALS INC	4.04	Reduce 7.00%	2,373,795	$86.97	$206.45M
SYRE hist	SPYRE THERAPEUTICS INC	3.73	Add 23.00%	3,783,225	$50.44	$190.83M
NUVL hist	NUVALENT INC	3.17	Reduce 5.00%	1,580,505	$102.45	$161.92M
EWTX hist	EDGEWISE THERAPEUTICS INC	2.73	Reduce 1.00%	4,423,974	$31.50	$139.35M
PTGX hist	PROTAGONIST THERAPEUTICS INC	2.54	Reduce 9.00%	1,230,879	$105.40	$129.74M
APGE hist	APOGEE THERAPEUTICS INC	2.54	Reduce 34.00%	1,540,384	$84.17	$129.65M
TVTX hist	TRAVERE THERAPEUTICS INC	2.41	Reduce 3.00%	4,142,551	$29.71	$123.08M
AMLX hist	AMYLYX PHARMACEUTICALS INC	2.25	—	8,284,882	$13.90	$115.16M
IMTX hist	IMMATICS N.V	2.00	—	10,383,456	$9.84	$102.17M
RLAY hist	RELAY THERAPEUTICS INC	1.90	Add 412.00%	9,751,141	$9.95	$97.02M
INBX hist	INHIBRX BIOSCIENCES INC	1.90	Reduce 1.00%	1,442,707	$67.23	$96.99M
MGTX hist	MEIRAGTX HLDGS PLC	1.75	—	10,326,103	$8.65	$89.31M
ZYME hist	ZYMEWORKS INC	1.72	Add 8.00%	3,510,078	$25.04	$87.89M
SLDB hist	SOLID BIOSCIENCES INC	1.68	Add 1.00%	11,906,646	$7.20	$85.73M
DYN hist	DYNE THERAPEUTICS INC	1.66	Add 34.00%	4,668,839	$18.13	$84.65M
BCRX hist	BIOCRYST PHARMACEUTICALS INC	1.38	Add 135.00%	7,434,033	$9.52	$70.77M
ORKA hist	ORUKA THERAPEUTICS INC	1.34	Reduce 5.00%	1,395,501	$49.05	$68.45M
AORT hist	ARTIVION INC	1.17	Reduce 5.00%	1,637,290	$36.62	$59.96M
NRIX hist	NURIX THERAPEUTICS INC	1.13	Add 4.00%	3,710,877	$15.50	$57.52M
MRNAPUThist	MODERNA INC	0.99	Buy	1,000,000	$50.80	$50.80M
NAUT hist	NAUTILUS BIOTECHNOLOGY INC	0.96	—	12,594,211	$3.88	$48.87M
CTMX hist	CYTOMX THERAPEUTICS INC.	0.93	Add 4.00%	10,098,824	$4.70	$47.46M
ANRO hist	ALTO NEUROSCIENCE INC	0.88	Add 13.00%	2,009,893	$22.48	$45.18M
ENGN hist	ENGENE HOLDINGS INC	0.78	Reduce 1.00%	5,827,506	$6.81	$39.69M
IMVT hist	IMMUNOVANT INC	0.78	Reduce 20.00%	1,597,383	$24.84	$39.68M
INTU hist	INTUITIVE SURGICAL INC	0.77	Reduce 3.00%	85,419	$460.99	$39.38M
IONS hist	IONIS PHARMACEUTICALS INC	0.74	Buy	504,000	$75.09	$37.84M
DAWN hist	DAY ONE BIOPHARMACEUTICALS I	0.74	Buy	1,755,799	$21.44	$37.64M
ABVX hist	ABIVAX SA	0.72	Reduce 28.00%	328,884	$111.35	$36.62M
CRVS hist	CORVUS PHARMACEUTICALS INC	0.66	Add 231.00%	2,292,441	$14.63	$33.54M
RGEN hist	REPLIGEN CORP	0.65	Reduce 11.00%	280,541	$117.82	$33.05M
JAZZ hist	JAZZ PHARMACEUTICALS PLC	0.63	—	170,000	$189.05	$32.14M
DMRA hist	DAMORA THERAPEUTICS INC	0.62	Buy	1,223,000	$25.90	$31.68M
XFOR hist	X4 PHARMACEUTICALS INC	0.54	Add 7.00%	6,737,648	$4.13	$27.83M
GH hist	GUARDANT HEALTH INC	0.54	Add 88.00%	300,000	$92.37	$27.71M
DRUG hist	BRIGHT MINDS BIOSCIENCES INC	0.54	Reduce 16.00%	377,544	$72.97	$27.55M
IVVD hist	INVIVYD INC	0.53	Reduce 4.00%	20,859,303	$1.30	$27.12M
SION hist	SIONNA THERAPEUTICS INC	0.52	Reduce 44.00%	658,439	$40.09	$26.40M
RVMD hist	REVOLUTION MEDICINES INC	0.50	Buy	508,600	$50.33	$25.60M
AXSM hist	AXSOME THERAPEUTICS INC.	0.50	Add 1.00%	149,950	$169.02	$25.34M
SABS hist	SAB BIOTHERAPEUTICS INC	0.48	Add 701.00%	6,431,743	$3.83	$24.63M
BLTE hist	BELITE BIO INC	0.47	Reduce 63.00%	151,979	$159.44	$24.23M
TENX hist	TENAX THERAPEUTICS INC	0.45	Add 230.00%	1,447,782	$15.99	$23.15M
AXGN hist	AXOGEN INC	0.45	Reduce 11.00%	697,312	$33.13	$23.10M
VRDN hist	VIRIDIAN THERAPEUTICS INC	0.45	Reduce 62.00%	1,170,829	$19.56	$22.90M
OBIO hist	ORCHESTRA BIOMED HLDGS INC	0.42	Reduce 2.00%	5,037,906	$4.25	$21.41M
RAPP hist	RAPPORT THERAPEUTICS INC	0.41	—	673,923	$31.29	$21.09M
DBVT hist	DBV TECHNOLOGIES S A	0.39	Buy	964,391	$20.89	$20.15M
LONA hist	LEONABIO INC	0.37	—	1,859,322	$10.28	$19.11M
AVR hist	ANTERIS TECHNOLOGIES GLOBAL	0.37	Add 104.00%	3,425,476	$5.55	$19.01M
STRO hist	SUTRO BIOPHARMA INC	0.35	Buy	715,307	$24.91	$17.82M
TNGX hist	TANGO THERAPEUTICS INC	0.33	Add 58.00%	808,153	$20.92	$16.91M
CTNM hist	CONTINEUM THERAPEUTICS INC	0.32	Reduce 14.00%	1,255,592	$13.06	$16.40M
PALI hist	PALISADE BIO INC	0.31	Reduce 26.00%	8,928,149	$1.75	$15.62M
OCS hist	OCULIS HOLDING AG	0.26	—	493,827	$26.59	$13.13M
IRTC hist	IRHYTHM HOLDINGS INC	0.24	Reduce 3.00%	105,026	$118.02	$12.39M
EVMN hist	EVOMMUNE INC	0.20	Buy	448,350	$22.99	$10.31M
PHAT hist	PHATHOM PHARMACEUTICALS INC	0.20	Buy	925,000	$11.11	$10.28M
NMRA hist	NEUMORA THERAPEUTICS INC.	0.19	Buy	5,104,097	$1.95	$9.95M
OMDA hist	OMADA HEALTH INC	0.19	Reduce 67.00%	786,330	$12.57	$9.88M
NBIX hist	NEUROCRINE BIOSCIENCES INC	0.17	Reduce 80.00%	65,050	$131.74	$8.57M
BBNX hist	BETA BIONICS INC	0.17	Add 40.00%	842,944	$10.02	$8.45M
IRD hist	OPUS GENETICS INC	0.16	Reduce 58.00%	1,835,842	$4.55	$8.35M
BLLN hist	BILLIONTOONE INC	0.14	Add 26.00%	91,812	$78.94	$7.25M
TWST hist	TWIST BIOSCIENCE CORP	0.14	Buy	150,000	$47.52	$7.13M
SRZN hist	SURROZEN INC	0.13	Buy	396,059	$16.88	$6.68M
AGMB hist	AGOMAB THERAPEUTICS NV	0.12	Buy	600,000	$10.49	$6.29M
EOLS hist	EVOLUS INC	0.10	Buy	1,286,862	$4.11	$5.29M
COGT hist	COGENT BIOSCIENCES INC	0.09	—	121,082	$38.49	$4.66M
ADGM hist	ADAGIO MED HLDGS INC	0.09	Reduce 62.00%	3,780,830	$1.15	$4.35M
OCULCALLhist	OCULAR THERAPEUTIX INC	0.08	Buy	500,000	$8.47	$4.24M
ADMA hist	ADMA BIOLOGICS INC	0.08	Reduce 47.00%	467,233	$9.01	$4.21M
IKT hist	INHIBIKASE THERAPEUTICS INC	0.08	Reduce 57.00%	2,315,000	$1.68	$3.89M
CBIO hist	CRESCENT BIOPHARMA INC.	0.07	Reduce 54.00%	206,942	$18.37	$3.80M
APLS hist	APELLIS PHARMACEUTICALS INC	0.06	Buy	80,956	$40.23	$3.26M
OM hist	OUTSET MED INC	0.06	—	833,333	$3.84	$3.20M
EDSA hist	EDESA BIOTECH INC	0.06	Buy	563,239	$5.23	$2.95M
ADPT hist	ADAPTIVE BIOTECHNOLOGIES COR	0.04	Buy	152,500	$13.88	$2.12M
AVTX hist	AVALO THERAPEUTICS INC	0.04	—	139,667	$14.93	$2.08M
CNTB hist	CONNECT BIOPHARMA HLDGS LTD	0.04	—	792,696	$2.62	$2.08M
CORT hist	CORCEPT THERAPEUTICS INC	0.04	Buy	50,000	$40.32	$2.02M
MDLN hist	MEDLINE INC	0.02	—	28,000	$44.50	$1.25M
PTN hist	PALATIN TECHNOLOGIES INC	0.02	Reduce 12.00%	61,945	$17.42	$1.08M
CPIX hist	CUMBERLAND PHARMACEUTICALS I	0.01	Reduce 42.00%	196,978	$3.25	$640K
XGN hist	EXAGEN INC	0.01	Buy	114,893	$3.00	$345K
ENSC hist	ENSYSCE BIOSCIENCES INC	0.00	—	86,666	$0.54	$47K
XBIPUThist	SPDR SERIES TRUST	0.00	Sell	0	—	$0
EXAS hist	EXACT SCIENCES CORP	0.00	Sell	0	—	$0
ACLX hist	ARCELLX INC	0.00	Sell	0	—	$0
BSX hist	BOSTON SCIENTIFIC CORP	0.00	Sell	0	—	$0
—	AMICUS THERAPEUTICS INC	0.00	Sell	0	—	$0
—	ASTRIA THERAPEUTICS INC	0.00	Sell	0	—	$0
DHR hist	DANAHER CORPORATION	0.00	Sell	0	—	$0
CDTX hist	CIDARA THERAPEUTICS INC	0.00	Sell	0	—	$0
IRON hist	DISC MEDICINE INC	0.00	Sell	0	—	$0
PEN hist	PENUMBRA INC	0.00	Sell	0	—	$0
CAI hist	CARIS LIFE SCIENCES INC	0.00	Sell	0	—	$0
—	RAPT THERAPEUTICS INC	0.00	Sell	0	—	$0
PVLA hist	PALVELLA THERAPEUTICS INC NE	0.00	Sell	0	—	$0
KOD hist	KODIAK SCIENCES INC	0.00	Sell	0	—	$0
BIIB hist	BIOGEN INC	0.00	Sell	0	—	$0
ALDX hist	ALDEYRA THERAPEUTICS INC	0.00	Sell	0	—	$0
MIRM hist	MIRUM PHARMACEUTICALS INC	0.00	Sell	0	—	$0
GRAL hist	GRAIL INC	0.00	Sell	0	—	$0
CVS hist	CVS HEALTH CORP	0.00	Sell	0	—	$0
GKOS hist	GLAUKOS CORP	0.00	Sell	0	—	$0
DXCM hist	DEXCOM INC	0.00	Sell	0	—	$0
SVRA hist	SAVARA INC	0.00	Sell	0	—	$0
SEPN hist	SEPTERNA INC	0.00	Sell	0	—	$0
GOSS hist	GOSSAMER BIO INC	0.00	Sell	0	—	$0
MPLT hist	MAPLIGHT THERAPEUTICS INC	0.00	Sell	0	—	$0
XENE hist	XENON PHARMACEUTICALS INC	0.00	Sell	0	—	$0
KMTS hist	KESTRA MED TECHNOLOGIES LTD	0.00	Sell	0	—	$0
CAPRCALLhist	CAPRICOR THERAPEUTICS INC	0.00	Sell	0	—	$0
BHVNCALLhist	BIOHAVEN LTD	0.00	Sell	0	—	$0
KYMR hist	KYMERA THERAPEUTICS INC	0.00	Sell	0	—	$0
PEPG hist	PEPGEN INC	0.00	Sell	0	—	$0
TECXCALLhist	TECTONIC THERAPEUTIC INC	0.00	Sell	0	—	$0
AQST hist	AQUESTIVE THERAPEUTICS INC	0.00	Sell	0	—	$0
KRYS hist	KRYSTAL BIOTECH INC	0.00	Sell	0	—	$0
OLMA hist	OLEMA PHARMACEUTICALS INC	0.00	Sell	0	—	$0
SDGR hist	SCHRODINGER INC	0.00	Sell	0	—	$0
IMMX hist	IMMIX BIOPHARMA INC	0.00	Sell	0	—	$0
LXEO hist	LEXEO THERAPEUTICS INC	0.00	Sell	0	—	$0
LENZ hist	LENZ THERAPEUTICS INC	0.00	Sell	0	—	$0
BDSX hist	BIODESIX	0.00	Sell	0	—	$0
NVNO hist	ENVVENO MEDICAL CORPORATION	0.00	Sell	0	—	$0
IOVA hist	IOVANCE BIOTHERAPEUTICS INC	0.00	Sell	0	—	$0
RVMD hist	REVOLUTION MEDICINES INC	0.00	Sell	0	—	$0
SRZN hist	SURROZEN INC	0.00	Sell	0	—	$0