Joseph Edelman – Perceptive Advisors LLC

Period:
Q1 2026
Portfolio date:
Mar 31, 2026
No. of stocks:
91
Portfolio value:
$5,110,912,000
Filed:
May 15, 2026
Style:
Biotech Specialist
HistStockActivityShare change% change to portfolio
Q1 2026filed May 15, 2620 new17 added22 reduced42 exited
≡CNTA – CENTESSA PHARMACEUTICALS PLCAdd 80.00%2,341,2692.79
≡ASND – ASCENDIS PHARMA A/SAdd 42.00%450,0002.74
≡XBIPUT – SPDR SERIES TRUSTSell−1,100,000−2.39
≡EXAS – EXACT SCIENCES CORPSell−1,200,487−2.17
≡SYRE – SPYRE THERAPEUTICS INCAdd 23.00%714,0001.94
≡ACLX – ARCELLX INCSell−1,466,071−1.70
≡BSX – BOSTON SCIENTIFIC CORPSell−979,000−1.66
≡AMICUS THERAPEUTICS INCSell−6,370,851−1.62
≡RLAY – RELAY THERAPEUTICS INCAdd 412.00%7,847,8961.61
≡ASTRIA THERAPEUTICS INCSell−6,485,420−1.51
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 62.00%−1,871,874−1.24
≡MRNAPUT – MODERNA INCBuy1,000,0000.99
≡BCRX – BIOCRYST PHARMACEUTICALS INCAdd 135.00%4,271,5040.95
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 7.00%−172,596−0.82
≡DHR – DANAHER CORPORATIONSell−200,000−0.82
≡IONS – IONIS PHARMACEUTICALS INCBuy504,0000.74
≡DAWN – DAY ONE BIOPHARMACEUTICALS IBuy1,755,7990.74
≡BLTE – BELITE BIO INCReduce 63.00%−262,260−0.71
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 80.00%−266,000−0.67
≡CDTX – CIDARA THERAPEUTICS INCSell−165,131−0.65
≡IRON – DISC MEDICINE INCSell−450,743−0.64
≡DMRA – DAMORA THERAPEUTICS INCBuy1,223,0000.62
≡PEN – PENUMBRA INCSell−110,529−0.61
≡APGE – APOGEE THERAPEUTICS INCReduce 34.00%−790,267−0.60
≡CRVS – CORVUS PHARMACEUTICALS INCAdd 231.00%1,600,0000.56
≡CAI – CARIS LIFE SCIENCES INCSell−1,136,206−0.55
≡RAPT THERAPEUTICS INCSell−825,890−0.50
≡PVLA – PALVELLA THERAPEUTICS INC NESell−266,287−0.50
≡RVMD – REVOLUTION MEDICINES INCBuy258,6000.49
≡OMDA – OMADA HEALTH INCReduce 67.00%−1,610,000−0.48
≡DYN – DYNE THERAPEUTICS INCAdd 34.00%1,189,8950.44
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 9.00%−119,5460.44
≡SABS – SAB BIOTHERAPEUTICS INCAdd 701.00%5,628,5330.43
≡KOD – KODIAK SCIENCES INCSell−848,900−0.42
≡DBVT – DBV TECHNOLOGIES S ABuy964,3910.39
≡BIIB – BIOGEN INCSell−124,000−0.39
≡ALDX – ALDEYRA THERAPEUTICS INCSell−4,185,632−0.39
≡ABVX – ABIVAX SAReduce 28.00%−129,459−0.39
≡MIRM – MIRUM PHARMACEUTICALS INCSell−259,545−0.37
≡GRAL – GRAIL INCSell−237,342−0.36
≡TENX – TENAX THERAPEUTICS INCAdd 230.00%1,008,6400.36
≡STRO – SUTRO BIOPHARMA INCBuy715,3070.35
≡SION – SIONNA THERAPEUTICS INCReduce 44.00%−520,659−0.35
≡ANRO – ALTO NEUROSCIENCE INCAdd 13.00%225,5000.32
≡CVS – CVS HEALTH CORPSell−220,000−0.31
≡GKOS – GLAUKOS CORPSell−140,000−0.28
≡RGEN – REPLIGEN CORPReduce 11.00%−35,000−0.27
≡DXCM – DEXCOM INCSell−225,758−0.27
≡SVRA – SAVARA INCSell−2,400,000−0.26
≡GH – GUARDANT HEALTH INCAdd 88.00%140,0000.25
≡TNGX – TANGO THERAPEUTICS INCAdd 58.00%295,1180.25
≡AVR – ANTERIS TECHNOLOGIES GLOBALAdd 104.00%1,750,0000.22
≡SEPN – SEPTERNA INCSell−433,160−0.22
≡ADMA – ADMA BIOLOGICS INCReduce 47.00%−416,235−0.20
≡EVMN – EVOMMUNE INCBuy448,3500.20
≡PHAT – PHATHOM PHARMACEUTICALS INCBuy925,0000.20
≡PALI – PALISADE BIO INCReduce 26.00%−3,121,851−0.20
≡NMRA – NEUMORA THERAPEUTICS INC.Buy5,104,0970.19
≡ZYME – ZYMEWORKS INCAdd 8.00%248,2280.19
≡GOSS – GOSSAMER BIO INCSell−3,139,669−0.17
≡MPLT – MAPLIGHT THERAPEUTICS INCSell−550,000−0.17
≡BBNX – BETA BIONICS INCAdd 40.00%240,000−0.16
≡XENE – XENON PHARMACEUTICALS INCSell−200,791−0.16
≡TWST – TWIST BIOSCIENCE CORPBuy150,0000.14
≡KMTS – KESTRA MED TECHNOLOGIES LTDSell−285,000−0.13
≡SRZN – SURROZEN INCBuy229,3930.13
≡IMVT – IMMUNOVANT INCReduce 20.00%−397,507−0.13
≡CAPRCALL – CAPRICOR THERAPEUTICS INCSell−242,100−0.12
≡AGMB – AGOMAB THERAPEUTICS NVBuy600,0000.12
≡IKT – INHIBIKASE THERAPEUTICS INCReduce 57.00%−3,106,568−0.12
≡EOLS – EVOLUS INCBuy1,286,8620.10
≡BHVNCALL – BIOHAVEN LTDSell−500,000−0.10
≡ADGM – ADAGIO MED HLDGS INCReduce 62.00%−6,095,746−0.10
≡KYMR – KYMERA THERAPEUTICS INCSell−69,935−0.10
≡PEPG – PEPGEN INCSell−829,870−0.10
≡XFOR – X4 PHARMACEUTICALS INCAdd 7.00%423,1960.09
≡TECXCALL – TECTONIC THERAPEUTIC INCSell−250,000−0.09
≡AQST – AQUESTIVE THERAPEUTICS INCSell−747,193−0.09
≡DRUG – BRIGHT MINDS BIOSCIENCES INCReduce 16.00%−71,746−0.09
≡OCULCALL – OCULAR THERAPEUTIX INCBuy500,0000.08
≡KRYS – KRYSTAL BIOTECH INCSell−17,500−0.08
≡OLMA – OLEMA PHARMACEUTICALS INCSell−165,713−0.07
≡SDGR – SCHRODINGER INCSell−202,400−0.06
≡APLS – APELLIS PHARMACEUTICALS INCBuy80,9560.06
≡EDSA – EDESA BIOTECH INCBuy563,2390.06
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORBuy152,5000.04
≡CORT – CORCEPT THERAPEUTICS INCBuy50,0000.04
≡BLLN – BILLIONTOONE INCAdd 26.00%19,0000.04
≡IMMX – IMMIX BIOPHARMA INCSell−338,941−0.03
≡LXEO – LEXEO THERAPEUTICS INCSell−139,835−0.02
≡CTNM – CONTINEUM THERAPEUTICS INCReduce 14.00%−209,0000.02
≡CBIO – CRESCENT BIOPHARMA INC.Reduce 54.00%−246,744−0.02
≡LENZ – LENZ THERAPEUTICS INCSell−50,000−0.01
≡BDSX – BIODESIXSell−108,694−0.01
≡CPIX – CUMBERLAND PHARMACEUTICALS IReduce 42.00%−144,109−0.01
≡NVNO – ENVVENO MEDICAL CORPORATIONSell−1,759,035−0.01
≡IRD – OPUS GENETICS INCReduce 58.00%−2,489,1580.01
≡IOVA – IOVANCE BIOTHERAPEUTICS INCSell−152,714−0.01
≡XGN – EXAGEN INCBuy114,8930.01
≡AXGN – AXOGEN INCReduce 11.00%−86,828−0.01
≡PTN – PALATIN TECHNOLOGIES INCReduce 12.00%−8,0550.00
Q4 2025filed Feb 17, 2641 new31 added17 reduced15 exited
≡PRAX – PRAXIS PRECISION MEDICINES IAdd 28.00%431,4328.14
≡ACLX – ARCELLX INCReduce 41.00%−1,002,282−4.02
≡RYTM – RHYTHM PHARMACEUTICALS INCBuy2,546,3913.67
≡MERUS N VSell−1,353,093−3.60
≡INSM – INSMED INCSell−702,130−2.86
≡XBIPUT – SPDR SERIES TRUSTBuy1,100,0002.39
≡AMLX – AMYLYX PHARMACEUTICALS INCReduce 7.00%−667,483−1.65
≡APGE – APOGEE THERAPEUTICS INCAdd 72.00%978,6621.62
≡VRNA – VERONA PHARMA PLCSell−524,088−1.58
≡AKERO THERAPEUTICS INCSell−1,135,766−1.52
≡CELC – CELCUITY INCAdd 7.00%203,8811.49
≡MGTX – MEIRAGTX HLDGS PLCReduce 18.00%−2,300,000−1.47
≡EXAS – EXACT SCIENCES CORPAdd 158.00%735,0001.45
≡SYRE – SPYRE THERAPEUTICS INCAdd 150.00%1,839,7801.21
≡BLTE – BELITE BIO INCAdd 732.00%364,4511.08
≡DYN – DYNE THERAPEUTICS INCAdd 544.00%2,938,5001.02
≡AORT – ARTIVION INCReduce 15.00%−297,710−1.02
≡PEN – PENUMBRA INCReduce 50.00%−110,018−0.97
≡IVVD – INVIVYD INCBuy21,785,1660.96
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 26.00%−119,000−0.95
≡NRIX – NURIX THERAPEUTICS INCAdd 151.00%2,139,7280.83
≡NUVL – NUVALENT INCAdd 7.00%102,769−0.83
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 6.00%−183,268−0.82
≡DHR – DANAHER CORPORATIONBuy200,0000.82
≡BSX – BOSTON SCIENTIFIC CORPAdd 216.00%669,0000.81
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 108.00%1,580,3030.80
≡INBX – INHIBRX BIOSCIENCES INCAdd 9.00%125,0000.78
≡CDTX – CIDARA THERAPEUTICS INCBuy165,1310.65
≡IRON – DISC MEDICINE INCBuy450,7430.64
≡ANRO – ALTO NEUROSCIENCE INCAdd 1049.00%1,629,0270.55
≡ENGN – ENGENE HOLDINGS INCAdd 180.00%3,771,8400.54
≡ZYME – ZYMEWORKS INCAdd 56.00%1,171,1870.52
≡JAZZ – JAZZ PHARMACEUTICALS PLCBuy170,0000.52
≡AQST – AQUESTIVE THERAPEUTICS INCReduce 80.00%−3,012,906−0.51
≡PALI – PALISADE BIO INCBuy12,050,0000.50
≡AXGN – AXOGEN INCBuy784,1400.46
≡XFOR – X4 PHARMACEUTICALS INCBuy6,314,4520.45
≡BCRX – BIOCRYST PHARMACEUTICALS INCBuy3,162,5290.44
≡BIIB – BIOGEN INCBuy124,0000.39
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 20.00%−1,036,679−0.38
≡MIRM – MIRUM PHARMACEUTICALS INCBuy259,5450.37
≡RAPT THERAPEUTICS INCAdd 349.00%642,0000.36
≡GRAL – GRAIL INCBuy237,3420.36
≡TVTX – TRAVERE THERAPEUTICS INCAdd 13.00%483,5650.35
≡IMTX – IMMATICS N.VAdd 11.00%1,000,000−0.31
≡CVS – CVS HEALTH CORPBuy220,0000.31
≡GH – GUARDANT HEALTH INCBuy160,0000.29
≡RLAY – RELAY THERAPEUTICS INCBuy1,903,2450.29
≡GKOS – GLAUKOS CORPBuy140,0000.28
≡DXCM – DEXCOM INCBuy225,7580.27
≡SVRA – SAVARA INCBuy2,400,0000.26
≡IRTC – IRHYTHM TECHNOLOGIES INCReduce 12.00%−15,000−0.26
≡EWTX – EDGEWISE THERAPEUTICSAdd 17.00%662,0800.23
≡INTU – INTUITIVE SURGICAL INCAdd 69.00%35,8000.23
≡CRVS – CORVUS PHARMACEUTICALS INCReduce 52.00%−746,154−0.20
≡PVLA – PALVELLA THERAPEUTICS INC NEReduce 33.00%−128,806−0.20
≡JANX – JANUX THERAPEUTICS INCSell−292,686−0.20
≡TEM – TEMPUS AI INCSell−85,000−0.19
≡ADMA – ADMA BIOLOGICS INCReduce 23.00%−270,000−0.19
≡LONA – ATHIRA PHARMA INCAdd 244.00%1,319,0260.19
≡IMVT – IMMUNOVANT INCAdd 26.00%407,0000.18
≡OCS – OCULIS HOLDING AGBuy493,8270.18
≡KYMR – KYMERA THERAPEUTICS INCReduce 59.00%−99,861−0.17
≡MPLT – MAPLIGHT THERAPEUTICS INCBuy550,0000.17
≡BBNX – BETA BIONICS INCAdd 117.00%325,0000.17
≡ABVX – ABIVAX SAAdd 18.00%69,7350.17
≡PTGX – PROTAGONIST THERAPEUTICS INCAdd 31.00%320,2910.17
≡HTFL – HEARTFLOW INCSell−150,000−0.14
≡KMTS – KESTRA MED TECHNOLOGIES LTDBuy285,0000.13
≡KOD – KODIAK SCIENCES INCAdd 34.00%214,3230.13
≡CAPRCALL – CAPRICOR THERAPEUTICS INCBuy242,1000.12
≡GOSS – GOSSAMER BIO INCReduce 18.00%−673,128−0.11
≡ORKA – ORUKA THERAPEUTICS INCAdd 16.00%208,4800.11
≡BLLN – BILLIONTOONE INCBuy72,8120.11
≡BHVNCALL – BIOHAVEN LTDBuy500,0000.10
≡RGEN – REPLIGEN CORPAdd 17.00%45,113−0.10
≡KRYS – KRYSTAL BIOTECH INCReduce 50.00%−17,500−0.10
≡TENX – TENAX THERAPEUTICS INCBuy439,1420.10
≡SCPHARMACEUTICALS INCSell−583,142−0.09
≡TECXCALL – TECTONIC THERAPEUTIC INCBuy250,0000.09
≡TNGX – TANGO THERAPEUTICS INCBuy513,0350.08
≡VKTX – VIKING THERAPEUTICS INCSell−105,597−0.08
≡COGT – COGENT BIOSCIENCES INCBuy121,0820.08
≡PYXS – PYXIS ONCOLOGY INCSell−1,178,307−0.07
≡OLMA – OLEMA PHARMACEUTICALS INCBuy165,7130.07
≡SEPN – SEPTERNA INCReduce 20.00%−108,290−0.07
≡SDGR – SCHRODINGER INCBuy202,4000.06
≡CTNM – CONTINEUM THERAPEUTICS INCAdd 105.00%750,0000.06
≡ROIV – ROIVANT SCIENCES LTDAdd 8.00%617,000−0.06
≡SPRYPUT – ARS PHARMACEUTICALS INCSell−200,000−0.06
≡SABS – SAB BIOTHERAPEUTICS INCBuy803,2100.05
≡TRIB – TRINITY BIOTECH PLCSell−1,790,000−0.05
≡LYRA – LYRA THERAPEUTICS INCSell−229,382−0.04
≡CNTB – CONNECT BIOPHARMA HLDGS LTDBuy792,6960.04
≡QURE – UNIQURE NVSell−20,000−0.03
≡IMMX – IMMIX BIOPHARMA INCBuy338,9410.03
≡RAPP – RAPPORT THERAPEUTICS INCAdd 67.00%270,0000.03
≡CPIX – CUMBERLAND PHARMACEUTICALS IBuy341,0870.02
≡MDLN – MEDLINE INCBuy28,0000.02
≡PTN – PALATIN TECHNOLOGIES INCBuy70,0000.02
≡LENZ – LENZ THERAPEUTICS INCBuy50,0000.01
≡APYX – APYX MEDICAL CORPORATIONSell−150,000−0.01
≡IOVA – IOVANCE BIOTHERAPEUTICS INCBuy152,7140.01
≡CELC – CELCUITY INCBuy6,500,0000.00
Q3 2025filed Nov 14, 2521 new28 added14 reduced13 exited
≡VRNA – VERONA PHARMA PLCReduce 90.00%−4,983,503−17.25
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 100.00%−2,418,299−4.34
≡CELC – CELCUITY INCAdd 81.00%1,323,1113.34
≡MERUS N VAdd 91.00%644,9172.25
≡TVTX – TRAVERE THERAPEUTICS INCAdd 355.00%2,960,3632.11
≡ROIV – ROIVANT SCIENCES LTDAdd 121.00%4,036,9961.79
≡AMLX – AMYLYX PHARMACEUTICALS INCAdd 13.00%1,050,0001.60
≡CNTA – CENTESSA PHARMACEUTICALS PLCAdd 170.00%1,953,9671.58
≡SLNO – SOLENO THERAPEUTICS INCSell−430,439−1.30
≡PEN – PENUMBRA INCAdd 572.00%187,7501.27
≡PRAX – PRAXIS PRECISION MEDICINES IAdd 108.00%811,6331.20
≡ABVX – ABIVAX SABuy388,6080.93
≡XBIPUT – SPDR SERIES TRUSTSell−300,000−0.90
≡EOLS – EVOLUS INCSell−2,474,843−0.82
≡INBX – INHIBRX BIOSCIENCES INCAdd 36.00%349,8150.76
≡AORT – ARTIVION INCReduce 28.00%−773,703−0.73
≡EXAS – EXACT SCIENCES CORPBuy465,4870.72
≡PVLA – PALVELLA THERAPEUTICS INC NEBuy395,0930.70
≡ORKA – ORUKA THERAPEUTICS INCBuy1,268,0210.69
≡PODD – INSULET CORPSell−60,387−0.69
≡BBNX – BETA BIONICS INCReduce 83.00%−1,315,664−0.68
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 227.00%1,014,8930.67
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 76.00%195,0000.63
≡IRTC – IRHYTHM TECHNOLOGIES INCBuy123,0000.60
≡DYN – DYNE THERAPEUTICS INCReduce 76.00%−1,706,946−0.58
≡CRL – CHARLES RIV LABS INTL INCSell−100,000−0.55
≡IMVT – IMMUNOVANT INCReduce 26.00%−550,000−0.51
≡INSM – INSMED INCAdd 8.00%51,8780.49
≡EWTX – EDGEWISE THERAPEUTICS INCReduce 18.00%−844,055−0.46
≡ZYME – ZYMEWORKS INCAdd 64.00%815,3890.43
≡ENGN – ENGENE HOLDINGS INCBuy2,097,2360.40
≡ADMA – ADMA BIOLOGICS INCReduce 12.00%−150,000−0.38
≡DRUG – BRIGHT MINDS BIOSCIENCES INCAdd 7.00%28,6000.37
≡RARE – ULTRAGENYX PHARMACEUTICAL INSell−270,000−0.35
≡APGE – APOGEE THERAPEUTICS INCAdd 14.00%169,841−0.34
≡RAPP – RAPPORT THERAPEUTICS INCBuy403,9230.34
≡AQST – AQUESTIVE THERAPEUTICS INCAdd 72.00%1,569,6790.33
≡CTMX – CYTOMX THERAPEUTICS INCAdd 38.00%2,686,5390.30
≡KOD – KODIAK SCIENCES INCBuy634,5770.29
≡VKTX – VIKING THERAPEUTICS INCReduce 72.00%−275,103−0.29
≡GOSS – GOSSAMER BIO INCBuy3,812,7970.28
≡RGEN – REPLIGEN CORPAdd 63.00%104,4280.27
≡CELC – CELCUITY INCBuy00.25
≡SYRE – SPYRE THERAPEUTICS INCReduce 20.00%−300,000−0.25
≡AKERO THERAPEUTICS INCAdd 24.00%219,879−0.24
≡AXSM – AXSOME THERAPEUTICS INCReduce 25.00%−49,634−0.24
≡CAPRPUT – CAPRICOR THERAPEUTICS INCSell−650,000−0.23
≡BSX – BOSTON SCIENTIFIC CORPAdd 11.00%30,000−0.23
≡ISRG – INTUITIVE SURGICAL INCAdd 16.00%7,000−0.23
≡ALDX – ALDEYRA THERAPEUTICS INCAdd 29.00%1,170,6800.21
≡TEM – TEMPUS AI INCBuy85,0000.19
≡GMED – GLOBUS MED INCSell−88,500−0.19
≡KRYS – KRYSTAL BIOTECH INCBuy35,0000.17
≡HLXC – HELIX ACQUISITION CORP IISell−398,000−0.15
≡HTFL – HEARTFLOW INCBuy150,0000.14
≡NVNO – ENVVENO MEDICAL CORPORATIONAdd 37.00%474,069−0.14
≡AMICUS THERAPEUTICS INCReduce 14.00%−1,041,979−0.12
≡PEPG – PEPGEN INCBuy829,8700.11
≡BLTE – BELITE BIO INCBuy49,7880.10
≡ASND – ASCENDIS PHARMA A/SAdd 13.00%124,6150.10
≡NRIX – NURIX THERAPEUTICS INCAdd 29.00%319,164−0.08
≡OBIO – ORCHESTRA BIOMED HLDGS INCAdd 15.00%700,000−0.07
≡PYXS – PYXIS ONCOLOGY INCBuy1,178,3070.07
≡LONA – ATHIRA PHARMA INCBuy540,2960.06
≡KYMR – KYMERA THERAPEUTICS INCReduce 19.00%−40,310−0.06
≡LONA – ATHIRA PHARMA INCSell−5,402,964−0.06
≡SPRYPUT – ARS PHARMACEUTICALS INCBuy200,0000.06
≡LYRA – LYRA THERAPEUTICS INCReduce 10.00%−25,768−0.04
≡QURE – UNIQURE NVBuy20,0000.03
≡FBRX – FORTE BIOSCIENCES INCSell−68,192−0.03
≡SCPHARMACEUTICALS INCAdd 17.00%83,1420.02
≡BDSX – BIODESIXBuy108,6940.02
≡NUVL – NUVALENT INCAdd 14.00%187,1560.02
≡BDSX – BIODESIX INCSell−2,173,880−0.02
≡ANRO – ALTO NEUROSCIENCE INCBuy155,3660.02
≡KALA – KALA BIO INCSell−55,227−0.01
Q2 2025filed Aug 14, 2522 new8 added27 reduced23 exited
≡ASND – ASCENDIS PHARMA A/SBuy963,8866.01
≡AMICUS THERAPEUTICS INCReduce 65.00%−14,051,697−4.60
≡VRNA – VERONA PHARMA PLCReduce 16.00%−1,055,7494.23
≡INTRA-CELLULAR THERAPIES INCSell−786,358−3.64
≡SLNO – SOLENO THERAPEUTICS INCReduce 71.00%−1,076,163−2.47
≡EWTX – EDGEWISE THERAPEUTICS INCAdd 828.00%4,139,9491.81
≡OMDA – OMADA HEALTH INCBuy2,426,3301.61
≡IOVA – IOVANCE BIOTHERAPEUTICS INCSell−12,711,788−1.48
≡ROIV – ROIVANT SCIENCES LTDBuy3,331,4651.36
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 56.00%−5,224,220−1.31
≡ARGX – ARGENX SESell−59,510−1.23
≡CAI – CARIS LIFE SCIENCES INCBuy1,098,1631.06
≡INSM – INSMED INCAdd 28.00%140,9521.00
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 62.00%−1,893,460−0.99
≡PCVX – VAXCYTE INCSell−706,567−0.94
≡EOLS – EVOLUS INCReduce 40.00%−1,654,299−0.92
≡XBIPUT – SPDR SERIES TRUSTBuy300,0000.90
≡ACLX – ARCELLX INCReduce 15.00%−448,478−0.83
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 155.00%155,0000.77
≡AXSM – AXSOME THERAPEUTICS INCReduce 44.00%−156,573−0.70
≡JANX – JANUX THERAPEUTICS INCReduce 70.00%−677,726−0.67
≡AKERO THERAPEUTICS INCAdd 16.00%122,9270.64
≡BSX – BOSTON SCIENTIFIC CORPAdd 115.00%150,0000.63
≡CTMX – CYTOMX THERAPEUTICS INCBuy6,993,6460.57
≡CRL – CHARLES RIV LABS INTL INCBuy100,0000.55
≡MDGL – MADRIGAL PHARMACEUTICALS INCSell−46,500−0.54
≡SYRE – SPYRE THERAPEUTICS INCReduce 34.00%−783,827−0.48
≡IMVT – IMMUNOVANT INCReduce 25.00%−706,182−0.47
≡TVTX – TRAVERE THERAPEUTICS INCBuy834,2520.45
≡DXCM – DEXCOM INCSell−178,000−0.43
≡ACRV – ACRIVON THERAPEUTICS INCSell−5,360,858−0.38
≡RARE – ULTRAGENYX PHARMACEUTICAL INBuy270,0000.35
≡CRGX – CARGO THERAPEUTICS INCSell−2,431,085−0.35
≡KYMR – KYMERA THERAPEUTICS INCBuy210,1060.33
≡NRIX – NURIX THERAPEUTICS INCAdd 269.00%799,4320.33
≡PEN – PENUMBRA INCBuy32,7970.30
≡EYPT – EYEPOINT PHARMACEUTICALS INCSell−1,537,274−0.29
≡NUVL – NUVALENT INCReduce 16.00%−258,788−0.27
≡CBIO – CRESCENT BIOPHARMA INC.Buy453,6860.26
≡IRON – DISC MEDICINE INCSell−150,000−0.26
≡CTNM – CONTINEUM THERAPEUTICS INCReduce 51.00%−741,763−0.25
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORSell−930,972−0.24
≡OCUL – OCULAR THERAPEUTIX INCSell−915,775−0.24
≡CAPRPUT – CAPRICOR THERAPEUTICS INCBuy650,0000.23
≡CRVS – CORVUS PHARMACEUTICALS INCBuy1,438,5950.21
≡SEPN – SEPTERNA INCBuy541,4500.21
≡DCTH – DELCATH SYS INCSell−462,422−0.21
≡ZYME – ZYMEWORKS INCReduce 32.00%−589,398−0.20
≡RAPT THERAPEUTICS INCSell−4,418,947−0.19
≡GMED – GLOBUS MED INCBuy88,5000.19
≡NVNO – ENVVENO MEDICAL CORPORATIONBuy1,284,9660.19
≡ISRG – INTUITIVE SURGICAL INCAdd 11.00%4,5000.18
≡KMTS – KESTRA MED TECHNOLOGIES LTDSell−200,000−0.17
≡RGEN – REPLIGEN CORPAdd 28.00%36,1990.17
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 23.00%−227,973−0.16
≡XENE – XENON PHARMACEUTICALS INCReduce 38.00%−124,533−0.16
≡OKUR – ONKURE THERAPEUTICS INCSell−1,004,439−0.15
≡AVTX – AVALO THERAPEUTICS INCReduce 73.00%−380,333−0.12
≡AQST – AQUESTIVE THERAPEUTICS INCReduce 41.00%−1,536,788−0.12
≡BBNX – BETA BIONICS INCReduce 28.00%−610,232−0.11
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 32.00%−212,155−0.09
≡LYRA – LYRA THERAPEUTICS INCBuy255,1500.08
≡IKT – INHIBIKASE THERAPEUTICS INCReduce 8.00%−492,707−0.07
≡MREO – MEREO BIOPHARMA GROUP PLCSell−876,961−0.07
≡VKTX – VIKING THERAPEUTICS INCReduce 25.00%−128,305−0.07
≡LYRA – LYRA THERAPEUTICS INCSell−12,757,562−0.06
≡RAPT THERAPEUTICS INCBuy183,8900.05
≡CELC – CELCUITY INCReduce 31.00%−729,071−0.05
≡KALA – KALA BIO INCReduce 80.00%−222,383−0.05
≡TRIB – TRINITY BIOTECH PLCBuy1,790,0000.04
≡AVR – ANTERIS TECHNOLOGIES GLOBALReduce 20.00%−434,870−0.04
≡CAPRCALL – CAPRICOR THERAPEUTICS INCBuy100,0000.04
≡TRAW – TRAWS PHARMA INCSell−421,781−0.03
≡RCKT – ROCKET PHARMACEUTICALS INCSell−140,726−0.03
≡FBRX – FORTE BIOSCIENCES INCBuy68,1920.03
≡PODD – INSULET CORPReduce 16.00%−11,2100.03
≡CGEM – CULLINAN THERAPEUTICS INCSell−80,100−0.02
≡INBX – INHIBRX BIOSCIENCES INCReduce 8.00%−86,134−0.02
≡APPLIED THERAPEUTICS INCSell−860,000−0.01
≡NBTX – NANOBIOTIXSell−105,053−0.01
Q1 2025filed May 15, 2515 new13 added29 reduced27 exited
≡EWTX – EDGEWISE THERAPEUTICS INCAdd 144.00%3,861,7913.10
≡IOVA – IOVANCE BIOTHERAPEUTICS INCReduce 43.00%−9,400,478−2.97
≡PCVX – VAXCYTE INCReduce 59.00%−1,011,850−2.89
≡EWTXCALL – EDGEWISE THERAPEUTICS INCReduce 81.00%−2,185,537−1.56
≡NUVL – NUVALENT INCReduce 38.00%−986,009−1.52
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 26.00%−348,841−1.48
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 52.00%−3,308,825−1.36
≡CRGX – CARGO THERAPEUTICS INCReduce 34.00%−1,251,919−1.10
≡INSM – INSMED INCAdd 254.00%365,3001.09
≡PODD – INSULET CORPReduce 69.00%−160,672−0.99
≡BBNX – BETA BIONICS INCBuy2,203,8400.95
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 31.00%−1,132,028−0.87
≡SLDB – SOLID BIOSCIENCES INCAdd 72.00%5,000,0000.79
≡INTRA-CELLULAR THERAPIES INCReduce 39.00%−501,9700.71
≡MERUS N VAdd 130.00%390,4850.68
≡VKTX – VIKING THERAPEUTICS INCReduce 49.00%−486,889−0.66
≡PRCT – PROCEPT BIOROBOTICS CORPSell−290,659−0.64
≡RGEN – REPLIGEN CORPBuy129,8010.58
≡MDGL – MADRIGAL PHARMACEUTICALS INCBuy46,5000.54
≡ADMA – ADMA BIOLOGICS INCAdd 54.00%482,9530.54
≡NTRA – NATERA INCSell−125,000−0.54
≡ACLX – ARCELLX INCReduce 16.00%−552,410−0.53
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 14.00%−180,3910.52
≡DYN – DYNE THERAPEUTICS INCAdd 326.00%1,770,1260.50
≡PEN – PENUMBRA INCSell−73,338−0.47
≡SEPN – SEPTERNA INCSell−750,000−0.47
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 56.00%−826,846−0.46
≡BSX – BOSTON SCIENTIFIC CORPBuy130,0000.46
≡SION – SIONNA THERAPEUTICS INCBuy1,251,1010.46
≡ORKA – ORUKA THERAPEUTICS INCSell−845,567−0.45
≡DXCM – DEXCOM INCBuy178,0000.43
≡ARVN – ARVINAS INCSell−740,749−0.39
≡AQST – AQUESTIVE THERAPEUTICS INCBuy3,727,2080.38
≡CGON – CG ONCOLOGY INCSell−419,450−0.33
≡OM – OUTSET MED INCBuy833,3330.32
≡SYRE – SPYRE THERAPEUTICS INCReduce 10.00%−261,451−0.32
≡EW – EDWARDS LIFESCIENCES CORPSell−145,000−0.29
≡TARS – TARSUS PHARMACEUTICALS INCSell−186,662−0.28
≡AMLX – AMYLYX PHARMACEUTICALS INCAdd 16.00%1,100,0000.28
≡JANX – JANUX THERAPEUTICS INCAdd 19.00%152,517−0.27
≡IMVT – IMMUNOVANT INCAdd 33.00%704,8730.26
≡IRON – DISC MEDICINE INCBuy150,0000.26
≡CRNX – CRINETICS PHARMACEUTICALS INSell−184,525−0.26
≡INARI MED INCSell−178,797−0.25
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORBuy930,9720.24
≡AKERO THERAPEUTICS INCReduce 33.00%−392,6320.23
≡EOLS – EVOLUS INCReduce 20.00%−1,016,7040.20
≡ISRG – INTUITIVE SURGICAL INCReduce 36.00%−22,500−0.19
≡DCTH – DELCATH SYS INCAdd 825.00%412,4220.19
≡APGE – APOGEE THERAPEUTICS INCAdd 7.00%75,5350.18
≡KMTS – KESTRA MED TECHNOLOGIES LTDBuy200,0000.17
≡DRUG – BRIGHT MINDS BIOSCIENCES INCAdd 10.00%41,0000.17
≡ZBIO – ZENAS BIOPHARMA INCSell−744,035−0.17
≡IRTC – IRHYTHM TECHNOLOGIES INCSell−65,153−0.16
≡RAPP – RAPPORT THERAPEUTICS INCSell−311,551−0.15
≡IRD – OPUS GENETICS INCBuy4,325,0000.15
≡AVTX – AVALO THERAPEUTICS INCBuy520,0000.15
≡CBLL – CERIBELL INCSell−180,546−0.13
≡VERU – VERU INCSell−6,483,157−0.11
≡ARGX – ARGENX SEReduce 12.00%−7,9610.11
≡CATX – PERSPECTIVE THERAPEUTICS INCSell−1,190,263−0.10
≡LCTX – LINEAGE CELL THERAPEUTICS INSell−7,236,843−0.10
≡RCKT – ROCKET PHARMACEUTICALS INCReduce 63.00%−237,858−0.10
≡PEPG – PEPGEN INCSell−829,536−0.09
≡IBRX – IMMUNITYBIO INCSell−1,221,734−0.09
≡AXSM – AXSOME THERAPEUTICS INCReduce 47.00%−308,967−0.08
≡BCYC – BICYCLE THERAPEUTICS PLCSell−197,108−0.08
≡AMICUS THERAPEUTICS INCReduce 11.00%−2,781,425−0.07
≡ZYME – ZYMEWORKS INCReduce 12.00%−265,348−0.07
≡RAPT THERAPEUTICS INCReduce 25.00%−1,461,053−0.06
≡VRCA – VERRICA PHARMACEUTICALS INCSell−3,249,669−0.06
≡FBRX – FORTE BIOSCIENCES INCSell−95,742−0.06
≡KALA – KALA BIO INCBuy277,6100.06
≡NRIX – NURIX THERAPEUTICS INCReduce 10.00%−33,061−0.05
≡TRIB – TRINITY BIOTECH PLCSell−1,790,000−0.04
≡MREO – MEREO BIOPHARMA GROUP PLCReduce 19.00%−208,551−0.03
≡FULC – FULCRUM THERAPEUTICS INCSell−238,000−0.03
≡NVAXPUT – NOVAVAX INCSell−100,000−0.02
≡CGEM – CULLINAN THERAPEUTICS INCBuy80,1000.02
≡OCUL – OCULAR THERAPEUTIX INCReduce 15.00%−162,720−0.02
≡HLXC – HELIX ACQUISITION CORP IIReduce 20.00%−102,0000.01
≡PYXS – PYXIS ONCOLOGY INCSell−188,462−0.01
≡NBTX – NANOBIOTIXReduce 61.00%−161,040−0.01
≡TRAW – TRAWS PHARMA INCAdd 157.00%257,624−0.01