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Data sourced from SEC EDGAR 13F filings

PricingTermsPrivacy© 2026 Super Investor · Not financial advice

Joseph Edelman – Perceptive Advisors

Period:
Q2 2026
Portfolio date:
Jun 30, 2026
No. of stocks:
109
Portfolio value:
$6,661,813,000
Filed:
Aug 14, 2026
Style:
Biotech Specialist
HistStockActivityShare change% change to portfolio
Q2 2026filed Aug 14, 2627 new24 added24 reduced12 exited
≡CNTA – CENTESSA PHARMACEUTICALS PLCSell−5,258,903−4.08
≡KARD – KARDIGAN INCBuy8,200,6622.94
≡ASND – ASCENDIS PHARMA A/SReduce 24.01%−367,700−2.19
≡RLAY – RELAY THERAPEUTICS INCAdd 44.66%4,355,0462.07
≡SYRE – SPYRE THERAPEUTICS INCAdd 14.17%536,2712.03
≡AVLN – AVALYN PHARMACEUTICALS INCBuy2,675,2961.32
≡TNGX – TANGO THERAPEUTICS INCAdd 317.87%2,568,8471.25
≡RVMD – REVOLUTION MEDICINES INCAdd 104.02%269,0000.99
≡BIIB – BIOGEN INCBuy276,1730.90
≡TVTX – TRAVERE THERAPEUTICS INCReduce 9.41%−389,9770.80
≡DYN – DYNE THERAPEUTICS INCReduce 42.40%−1,979,604−0.76
≡DAY ONE BIOPHARMACEUTICALS ISell−1,755,799−0.74
≡UNH – UNITEDHEALTH GROUP INCBuy116,8060.73
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 20.23%−249,000−0.73
≡XBIPUT – SPDR SERIES TRUSTBuy300,0000.71
≡ENGN – ENGENE THERAPEUTICS INCReduce 17.25%−1,005,337−0.65
≡NAUT – NAUTILUS BIOTECHNOLOGY INCReduce 7.62%−960,000−0.63
≡AORT – ARTIVION INCAdd 6.11%100,000−0.59
≡ABVX – ABIVAX SAReduce 77.50%−254,884−0.57
≡DRUG – BRIGHT MINDS BIOSCIENCES INCSell−377,544−0.54
≡CORT – CORCEPT THERAPEUTICS INCAdd 696.77%348,3850.48
≡CRL – CHARLES RIV LABS INTL INCBuy140,0000.48
≡BLTE – BELITE BIO INCSell−151,979−0.47
≡ISRG – INTUITIVE SURGICAL INCReduce 39.26%−33,535−0.46
≡NRIX – NURIX THERAPEUTICS INCAdd 16.43%609,5450.45
≡GH – GUARDANT HEALTH INCReduce 86.22%−258,673−0.45
≡EYPTPUT – EYEPOINT INCBuy2,000,0000.43
≡DHR – DANAHER CORP DELBuy130,0000.37
≡CAPRCALL – CAPRICOR THERAPEUTICS INCBuy1,000,0000.36
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORAdd 698.25%1,064,8250.35
≡SLSPUT – SELLAS LIFE SCIENCES GROUP IBuy1,500,0000.33
≡ANL – ADLAI NORTYE LTDBuy1,793,1900.31
≡STRO – SUTRO BIOPHARMA INCAdd 82.42%589,5390.30
≡IVVD – INVIVYD INCReduce 11.36%−2,368,667−0.29
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 50.29%−588,849−0.29
≡AXGN – AXOGEN INCReduce 64.53%−450,000−0.28
≡RYTM – RHYTHM PHARMACEUTICALS INCAdd 8.95%212,5000.28
≡NVCT – NUVECTIS PHARMA INCBuy1,000,0000.28
≡NAMSPUT – NEWAMSTERDAM PHARMA COMPANYBuy500,0000.25
≡ANRO – ALTO NEUROSCIENCE INCReduce 19.90%−400,000−0.25
≡MIRM – MIRUM PHARMACEUTICALS INCBuy115,3910.20
≡EVMN – EVOMMUNE INCSell−448,350−0.20
≡NMRA – NEUMORA THERAPEUTICS INC.Sell−5,104,097−0.19
≡CAPRPUT – CAPRICOR THERAPEUTICS INCBuy500,0000.18
≡OSCR – OSCAR HEALTH INCBuy400,0000.17
≡NBIX – NEUROCRINE BIOSCIENCES INCSell−65,050−0.17
≡BCRX – BIOCRYST PHARMACEUTICALS INCAdd 38.67%2,874,8550.16
≡IRD – OPUS GENETICS INCSell−1,835,842−0.16
≡SPTX – SEAPORT THERAPEUTICS INCBuy500,0000.16
≡BSX – BOSTON SCIENTIFIC CORPBuy250,0000.16
≡IRTC – IRHYTHM HOLDINGS INCAdd 113.06%118,7400.16
≡EOLS – EVOLUS INCAdd 91.11%1,172,4230.15
≡NTRA – NATERA INCBuy34,6890.14
≡RGEN – REPLIGEN CORPReduce 11.52%−32,329−0.14
≡RACC – RESEARCH ALLIANCE CORP IIIBuy750,0000.12
≡CGEM – CULLINAN THERAPEUTICS INCBuy426,4780.12
≡QURE – UNIQURE NVBuy168,0000.12
≡PHAT – PHATHOM PHARMACEUTICALS INCReduce 42.49%−393,000−0.11
≡MOBI – MOBIA MED INCBuy523,6540.11
≡OCS – OCULIS HOLDING AGAdd 63.79%315,000−0.09
≡OCULCALL – OCULAR THERAPEUTIX INCSell−500,000−0.08
≡TWST – TWIST BIOSCIENCE CORPReduce 75.46%−113,188−0.08
≡SION – SIONNA THERAPEUTICS INCAdd 37.45%246,5610.08
≡TENX – TENAX THERAPEUTICS INCAdd 17.42%252,218−0.08
≡ZYME – ZYMEWORKS INCAdd 19.17%672,875−0.08
≡IKT – INHIBIKASE THERAPEUTICS INCSell−2,315,000−0.08
≡OTLK – OUTLOOK THERAPEUTICS INCBuy3,139,2160.07
≡APGE – APOGEE THERAPEUTICS INCReduce 15.08%−232,2710.07
≡RAPP – RAPPORT THERAPEUTICS INCAdd 14.75%99,4190.07
≡ADMA – ADMA BIOLOGICS INCReduce 75.65%−353,468−0.07
≡IONS – IONIS PHARMACEUTICALS INCAdd 12.30%62,000−0.07
≡SRZN – SURROZEN INCAdd 119.70%274,5920.07
≡APELLIS PHARMACEUTICALS INCSell−80,956−0.06
≡AXSM – AXSOME THERAPEUTICS INC.Reduce 21.01%−31,500−0.06
≡CRVS – CORVUS PHARMACEUTICALS INCAdd 16.36%375,000−0.06
≡XERS – XERIS BIOPHARMA HOLDINGS INCBuy467,0130.06
≡INBX – INHIBRX BIOSCIENCES INCReduce 10.05%−144,944−0.05
≡PALI – PALISADE BIO INCReduce 5.63%−503,084−0.04
≡BDSX – BIODESIX INCBuy108,6940.04
≡PTN – PALATIN TECHNOLOGIES INCSell−61,945−0.02
≡AVTX – AVALO THERAPEUTICS INCAdd 57.38%80,1460.02
≡KPRX – KIORA PHARMACEUTICALS INCBuy438,4710.02
≡BLLN – BILLIONTOONE INCReduce 5.45%−5,0000.01
≡DBVT – DBV TECHNOLOGIES S AAdd 71.44%688,9590.01
≡XFOR – X4 PHARMACEUTICALS INCAdd 17.75%1,195,8430.01
≡IMVT – IMMUNOVANT INCReduce 15.02%−240,0000.01
≡CPIX – CUMBERLAND PHARMACEUTICALS IReduce 50.77%−99,996−0.00
Q1 2026filed May 29, 2620 new17 added23 reduced42 exited
≡CNTA – CENTESSA PHARMACEUTICALS PLCAdd 80.25%2,341,2692.78
≡ASND – ASCENDIS PHARMA A/SAdd 41.61%450,0002.73
≡XBIPUT – SPDR SERIES TRUSTSell−1,100,000−2.39
≡EXACT SCIENCES CORPSell
Q4 2025filed Feb 17, 2640 new31 added17 reduced15 exited
≡PRAX – PRAXIS PRECISION MEDICINES IAdd 27.58%431,4328.14
≡ARCELLX INCReduce 40.61%−1,002,282−4.02
≡MRUS 10/21/22 P30 – MERUS N VSell−1,353,093−3.60
≡INSM – INSMED INCSell−702,130−2.86
Q3 2025filed Nov 14, 2520 new28 added14 reduced13 exited
≡VERONA PHARMA PLCReduce 90.48%−4,983,503−17.25
≡CELC – CELCUITY INCAdd 81.01%1,323,1113.34
≡MRUS 10/21/22 P30 – MERUS N VAdd 91.07%644,9172.25
≡TVTX – TRAVERE THERAPEUTICS INCAdd 354.85%2,960,363
Q2 2025filed Aug 14, 2523 new8 added31 reduced25 exited
≡ASND – ASCENDIS PHARMA A/SBuy963,8866.01
≡AMICUS THERAPEUTICS INCReduce 65.46%−14,051,697−4.65
≡VERONA PHARMA PLCReduce 16.09%−1,055,7494.11
≡INTRA-CELLULAR THERAPIES INCSell−786,358−3.66
≡
Q1 2025filed Aug 6, 2519 new12 added27 reduced31 exited
≡EWTX – EDGEWISE THERAPEUTICS INCAdd 143.80%3,861,7913.14
≡IOVA – IOVANCE BIOTHERAPEUTICS INCReduce 42.51%−9,400,478−2.95
≡PCVX – VAXCYTE INCReduce 58.88%−1,011,850−2.88
≡NUVL – NUVALENT INCReduce 37.63%−986,009
Q4 2024filed Feb 14, 2524 new9 added39 reduced33 exited
≡SOLENO THERAPEUTICS INCReduce 53.17%−1,703,936−1.59
≡BHVN – BIOHAVEN LTDSell−1,485,232−1.57
≡APLT – APPLIED THERAPEUTICS INCReduce 89.26%−7,145,000−1.42
≡PRAX – PRAXIS PRECISION MEDICINES IAdd 14.23%165,7001.37
Q3 2024filed Nov 14, 2417 new20 added21 reduced19 exited
≡CEREVEL THERAPEUTICS HLDNG ISell−10,794,876−10.63
≡VERONA PHARMA PLCAdd 159.52%3,882,2083.00
≡NUVL – NUVALENT INCAdd 16.88%430,1581.79
≡MDGL – MADRIGAL PHARMACEUTICALS INCSell−264,600−1.79
Q2 2024filed Aug 16, 2421 new18 added30 reduced23 exited
≡FUSION PHARMACEUTICALS INCSell−6,825,395−2.55
≡INBX – INHIBRX BIOSCIENCES INCReduce 75.00%−3,192,078−2.24
≡INTRA-CELLULAR THERAPIES INCAdd 62.64%661,0521.55
≡IMTX – IMMATICS N.VAdd 76.46%3,503,7501.42
Q1 2024filed Aug 6, 2429 new35 added15 reduced18 exited
≡LIANY – LIANBIOSell−57,558,451−5.74
≡IOVA – IOVANCE BIOTHERAPEUTICS INCAdd 60.88%7,293,5762.82
≡CYMABAY THERAPEUTICS INCSell−4,024,400−2.12
≡FUSION PHARMACEUTICALS INCAdd 148.07%4,074,0001.96
Q4 2023filed Feb 26, 2423 new26 added17 reduced19 exited
≡CEREVEL THERAPEUTICS HLDNG IAdd 8.69%876,8083.03
≡IMVT – IMMUNOVANT INCReduce 38.97%−1,486,609−2.70
≡ARGX – ARGENX SESell−150,600−2.47
≡AKRO – AKERO THERAPEUTICS INCReduce 40.24%−651,650−2.23
Q3 2023filed Nov 14, 2317 new21 added23 reduced15 exited
≡IMVT – IMMUNOVANT INCAdd 51.15%1,290,9083.50
≡SOLENO THERAPEUTICS INCAdd 39.26%866,7892.75
≡APELLIS PHARMACEUTICALS INCSell−812,037−2.14
≡REATA PHARMACEUTICALS INCSell−670,206−1.98
−1,200,487
−2.17
≡SYRE – SPYRE THERAPEUTICS INCAdd 23.26%714,0001.94
≡ARCELLX INCSell−1,466,071−1.70
≡BSX – BOSTON SCIENTIFIC CORPSell−979,000−1.66
≡AMICUS THERAPEUTICS INCSell−6,370,851−1.62
≡RLAY – RELAY THERAPEUTICS INCAdd 412.34%7,847,8961.61
≡ASTRIA THERAPEUTICS INCSell−6,485,420−1.51
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 61.52%−1,871,874−1.24
≡MRNAPUT – MODERNA INCBuy1,000,0000.99
≡BCRX – BIOCRYST PHARMACEUTICALS INCAdd 135.07%4,271,5040.94
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 6.78%−172,596−0.82
≡DHR – DANAHER CORPORATIONSell−200,000−0.82
≡IONS – IONIS PHARMACEUTICALS INCBuy504,0000.74
≡DAY ONE BIOPHARMACEUTICALS IBuy1,755,7990.74
≡BLTE – BELITE BIO INCReduce 63.31%−262,260−0.71
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 80.35%−266,000−0.67
≡CDTX – CIDARA THERAPEUTICS INCSell−165,131−0.65
≡IRON – DISC MEDICINE INCSell−450,743−0.64
≡DMRA – DAMORA THERAPEUTICS INCBuy1,223,0000.62
≡PEN – PENUMBRA INCSell−110,529−0.61
≡APGE – APOGEE THERAPEUTICS INCReduce 33.91%−790,267−0.60
≡CRVS – CORVUS PHARMACEUTICALS INCAdd 231.07%1,600,0000.56
≡CAI – CARIS LIFE SCIENCES INCSell−1,136,206−0.55
≡ORKA – ORUKA THERAPEUTICS INCReduce 5.49%−81,0000.54
≡RAPT THERAPEUTICS INCSell−825,890−0.50
≡PVLA – PALVELLA THERAPEUTICS INC NESell−266,287−0.50
≡RVMD – REVOLUTION MEDICINES INCBuy258,6000.49
≡OMDA – OMADA HEALTH INCReduce 67.19%−1,610,000−0.48
≡DYN – DYNE THERAPEUTICS INCAdd 34.20%1,189,8950.44
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 8.85%−119,5460.43
≡SABS – SAB BIOTHERAPEUTICS INCAdd 700.75%5,628,5330.43
≡KOD – KODIAK SCIENCES INCSell−848,900−0.42
≡DBVT – DBV TECHNOLOGIES S ABuy964,3910.39
≡BIIB – BIOGEN INCSell−124,000−0.39
≡ALDX – ALDEYRA THERAPEUTICS INCSell−4,185,632−0.39
≡ABVX – ABIVAX SAReduce 28.25%−129,459−0.39
≡MIRM – MIRUM PHARMACEUTICALS INCSell−259,545−0.37
≡GRAL – GRAIL INCSell−237,342−0.36
≡TENX – TENAX THERAPEUTICS INCAdd 229.68%1,008,6400.36
≡SION – SIONNA THERAPEUTICS INCReduce 44.16%−520,659−0.35
≡STRO – SUTRO BIOPHARMA INCBuy715,3070.35
≡ANRO – ALTO NEUROSCIENCE INCAdd 12.64%225,5000.32
≡CVS – CVS HEALTH CORPSell−220,000−0.31
≡GKOS – GLAUKOS CORPSell−140,000−0.28
≡RGEN – REPLIGEN CORPReduce 11.09%−35,000−0.28
≡DXCM – DEXCOM INCSell−225,758−0.27
≡SVRA – SAVARA INCSell−2,400,000−0.26
≡GH – GUARDANT HEALTH INCAdd 87.50%140,0000.25
≡TNGX – TANGO THERAPEUTICS INCAdd 57.52%295,1180.25
≡AVR – ANTERIS TECHNOLOGIES GLOBALAdd 104.45%1,750,0000.22
≡SEPN – SEPTERNA INCSell−433,160−0.22
≡ADMA – ADMA BIOLOGICS INCReduce 47.11%−416,235−0.20
≡EVMN – EVOMMUNE INCBuy448,3500.20
≡PHAT – PHATHOM PHARMACEUTICALS INCBuy925,0000.20
≡PALI – PALISADE BIO INCReduce 25.91%−3,121,851−0.20
≡NMRA – NEUMORA THERAPEUTICS INC.Buy5,104,0970.19
≡ZYME – ZYMEWORKS INCAdd 7.61%248,2280.19
≡NUVL – NUVALENT INCReduce 5.08%−84,6000.18
≡GOSS – GOSSAMER BIO INCSell−3,139,669−0.17
≡MPLT – MAPLIGHT THERAPEUTICS INCSell−550,000−0.17
≡BBNX – BETA BIONICS INCAdd 39.80%240,000−0.16
≡XENE – XENON PHARMACEUTICALS INCSell−200,791−0.16
≡TWST – TWIST BIOSCIENCE CORPBuy150,0000.14
≡KMTS – KESTRA MED TECHNOLOGIES LTDSell−285,000−0.13
≡SRZN – SURROZEN INCBuy229,3930.13
≡IMVT – IMMUNOVANT INCReduce 19.93%−397,507−0.13
≡CAPRCALL – CAPRICOR THERAPEUTICS INCSell−242,100−0.12
≡AGMB – AGOMAB THERAPEUTICS NVBuy600,0000.12
≡IKT – INHIBIKASE THERAPEUTICS INCReduce 57.30%−3,106,568−0.12
≡EOLS – EVOLUS INCBuy1,286,8620.10
≡BHVNCALL – BIOHAVEN LTDSell−500,000−0.10
≡KYMR – KYMERA THERAPEUTICS INCSell−69,935−0.10
≡PEPG – PEPGEN INCSell−829,870−0.10
≡XFOR – X4 PHARMACEUTICALS INCAdd 6.70%423,1960.09
≡TECXCALL – TECTONIC THERAPEUTIC INCSell−250,000−0.09
≡DRUG – BRIGHT MINDS BIOSCIENCES INCReduce 15.97%−71,746−0.09
≡AQST – AQUESTIVE THERAPEUTICS INCSell−747,193−0.09
≡OCULCALL – OCULAR THERAPEUTIX INCBuy500,0000.08
≡KRYS – KRYSTAL BIOTECH INCSell−17,500−0.08
≡OLMA – OLEMA PHARMACEUTICALS INCSell−165,713−0.07
≡SDGR – SCHRODINGER INCSell−202,400−0.06
≡APELLIS PHARMACEUTICALS INCBuy80,9560.06
≡EDSA – EDESA BIOTECH INCBuy563,2390.06
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORBuy152,5000.04
≡CORT – CORCEPT THERAPEUTICS INCBuy50,0000.04
≡BLLN – BILLIONTOONE INCAdd 26.09%19,0000.04
≡IMMX – IMMIX BIOPHARMA INCSell−338,941−0.03
≡LXEO – LEXEO THERAPEUTICS INCSell−139,835−0.02
≡CTNM – CONTINEUM THERAPEUTICS INCReduce 14.27%−209,0000.02
≡CBIO – CRESCENT BIOPHARMA INC.Reduce 54.39%−246,744−0.02
≡LENZ – LENZ THERAPEUTICS INCSell−50,000−0.01
≡BDSX – BIODESIXSell−108,694−0.01
≡CPIX – CUMBERLAND PHARMACEUTICALS IReduce 42.25%−144,109−0.01
≡NVNO – ENVVENO MEDICAL CORPORATIONSell−1,759,035−0.01
≡IRD – OPUS GENETICS INCReduce 57.55%−2,489,1580.01
≡IOVA – IOVANCE BIOTHERAPEUTICS INCSell−152,714−0.01
≡XGN – EXAGEN INCBuy114,8930.01
≡AXGN – AXOGEN INCReduce 11.07%−86,828−0.01
≡PTN – PALATIN TECHNOLOGIES INCReduce 11.51%−8,0550.00
≡XBIPUT – SPDR SERIES TRUSTBuy1,100,0002.39
≡AMLX – AMYLYX PHARMACEUTICALS INCReduce 7.46%−667,483−1.65
≡APGE – APOGEE THERAPEUTICS INCAdd 72.39%978,6621.62
≡VERONA PHARMA PLCSell−524,088−1.58
≡AKRO – AKERO THERAPEUTICS INCSell−1,135,766−1.52
≡CELC – CELCUITY INCAdd 6.90%203,8811.49
≡MGTX – MEIRAGTX HLDGS PLCReduce 18.22%−2,300,000−1.47
≡EXACT SCIENCES CORPAdd 157.90%735,0001.45
≡SYRE – SPYRE THERAPEUTICS INCAdd 149.64%1,839,7801.21
≡BLTE – BELITE BIO INCAdd 732.01%364,4511.08
≡DYN – DYNE THERAPEUTICS INCAdd 543.72%2,938,5001.02
≡AORT – ARTIVION INCReduce 14.74%−297,710−1.02
≡PEN – PENUMBRA INCReduce 49.88%−110,018−0.97
≡IVVD – INVIVYD INCBuy21,785,1660.96
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 26.44%−119,000−0.95
≡NRIX – NURIX THERAPEUTICS INCAdd 151.09%2,139,7280.83
≡NUVL – NUVALENT INCAdd 6.58%102,769−0.83
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 5.91%−183,268−0.82
≡DHR – DANAHER CORPORATIONBuy200,0000.82
≡BSX – BOSTON SCIENTIFIC CORPAdd 215.81%669,0000.81
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 108.06%1,580,3030.80
≡INBX – INHIBRX BIOSCIENCES INCAdd 9.41%125,0000.78
≡CDTX – CIDARA THERAPEUTICS INCBuy165,1310.65
≡IRON – DISC MEDICINE INCBuy450,7430.64
≡ANRO – ALTO NEUROSCIENCE INCAdd 1048.51%1,629,0270.55
≡ENGN – ENGENE HOLDINGS INCAdd 179.85%3,771,8400.54
≡ZYME – ZYMEWORKS INCAdd 56.02%1,171,1870.52
≡JAZZ – JAZZ PHARMACEUTICALS PLCBuy170,0000.52
≡AQST – AQUESTIVE THERAPEUTICS INCReduce 80.13%−3,012,906−0.51
≡PALI – PALISADE BIO INCBuy12,050,0000.50
≡AXGN – AXOGEN INCBuy784,1400.46
≡XFOR – X4 PHARMACEUTICALS INCBuy6,314,4520.45
≡BCRX – BIOCRYST PHARMACEUTICALS INCBuy3,162,5290.44
≡BIIB – BIOGEN INCBuy124,0000.39
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 19.85%−1,036,679−0.38
≡MIRM – MIRUM PHARMACEUTICALS INCBuy259,5450.37
≡RAPT THERAPEUTICS INCAdd 349.12%642,0000.36
≡GRAL – GRAIL INCBuy237,3420.36
≡TVTX – TRAVERE THERAPEUTICS INCAdd 12.74%483,5650.35
≡IMTX – IMMATICS N.VAdd 10.66%1,000,000−0.31
≡CVS – CVS HEALTH CORPBuy220,0000.31
≡GH – GUARDANT HEALTH INCBuy160,0000.29
≡RLAY – RELAY THERAPEUTICS INCBuy1,903,2450.29
≡GKOS – GLAUKOS CORPBuy140,0000.28
≡DXCM – DEXCOM INCBuy225,7580.27
≡SVRA – SAVARA INCBuy2,400,0000.26
≡IRTC – IRHYTHM TECHNOLOGIES INCReduce 12.20%−15,000−0.26
≡EWTX – EDGEWISE THERAPEUTICSAdd 17.44%662,0800.23
≡ISRG – INTUITIVE SURGICAL INCAdd 68.69%35,8000.23
≡CRVS – CORVUS PHARMACEUTICALS INCReduce 51.87%−746,154−0.20
≡PVLA – PALVELLA THERAPEUTICS INC NEReduce 32.60%−128,806−0.20
≡JANX – JANUX THERAPEUTICS INCSell−292,686−0.20
≡TEM – TEMPUS AI INCSell−85,000−0.19
≡ADMA – ADMA BIOLOGICS INCReduce 23.41%−270,000−0.19
≡LONA – ATHIRA PHARMA INCAdd 244.13%1,319,0260.19
≡IMVT – IMMUNOVANT INCAdd 25.63%407,0000.18
≡OCS – OCULIS HOLDING AGBuy493,8270.18
≡KYMR – KYMERA THERAPEUTICS INCReduce 58.81%−99,861−0.17
≡MPLT – MAPLIGHT THERAPEUTICS INCBuy550,0000.17
≡BBNX – BETA BIONICS INCAdd 116.93%325,0000.17
≡ABVX – ABIVAX SAAdd 17.94%69,7350.17
≡PTGX – PROTAGONIST THERAPEUTICS INCAdd 31.09%320,2910.17
≡HTFL – HEARTFLOW INCSell−150,000−0.14
≡KMTS – KESTRA MED TECHNOLOGIES LTDBuy285,0000.13
≡KOD – KODIAK SCIENCES INCAdd 33.77%214,3230.13
≡CAPRCALL – CAPRICOR THERAPEUTICS INCBuy242,1000.12
≡GOSS – GOSSAMER BIO INCReduce 17.65%−673,128−0.11
≡ORKA – ORUKA THERAPEUTICS INCAdd 16.44%208,4800.11
≡BLLN – BILLIONTOONE INCBuy72,8120.11
≡BHVNCALL – BIOHAVEN LTDBuy500,0000.10
≡RGEN – REPLIGEN CORPAdd 16.68%45,113−0.10
≡KRYS – KRYSTAL BIOTECH INCReduce 50.00%−17,500−0.10
≡TENX – TENAX THERAPEUTICS INCBuy439,1420.10
≡SCPH – SCPHARMACEUTICALS INCSell−583,142−0.09
≡TECXCALL – TECTONIC THERAPEUTIC INCBuy250,0000.09
≡TNGX – TANGO THERAPEUTICS INCBuy513,0350.08
≡VKTX – VIKING THERAPEUTICS INCSell−105,597−0.08
≡COGT – COGENT BIOSCIENCES INCBuy121,0820.08
≡PYXS – PYXIS ONCOLOGY INCSell−1,178,307−0.07
≡OLMA – OLEMA PHARMACEUTICALS INCBuy165,7130.07
≡SEPN – SEPTERNA INCReduce 20.00%−108,290−0.07
≡SDGR – SCHRODINGER INCBuy202,4000.06
≡CTNM – CONTINEUM THERAPEUTICS INCAdd 104.95%750,0000.06
≡ROIV – ROIVANT SCIENCES LTDAdd 8.37%617,000−0.06
≡SPRYPUT – ARS PHARMACEUTICALS INCSell−200,000−0.06
≡SABS – SAB BIOTHERAPEUTICS INCBuy803,2100.05
≡TRIB – TRINITY BIOTECH PLCSell−1,790,000−0.05
≡LYRA – LYRA THERAPEUTICS INCSell−229,382−0.04
≡CNTB – CONNECT BIOPHARMA HLDGS LTDBuy792,6960.04
≡QURE – UNIQURE NVSell−20,000−0.03
≡IMMX – IMMIX BIOPHARMA INCBuy338,9410.03
≡RAPP – RAPPORT THERAPEUTICS INCAdd 66.84%270,0000.03
≡CPIX – CUMBERLAND PHARMACEUTICALS IBuy341,0870.02
≡MDLN – MEDLINE INCBuy28,0000.02
≡PTN – PALATIN TECHNOLOGIES INCBuy70,0000.02
≡LENZ – LENZ THERAPEUTICS INCBuy50,0000.01
≡APYX – APYX MEDICAL CORPORATIONSell−150,000−0.01
≡IOVA – IOVANCE BIOTHERAPEUTICS INCBuy152,7140.01
≡CELCUITY INCBuy6,500,0000.00
2.11
≡ROIV – ROIVANT SCIENCES LTDAdd 121.18%4,036,9961.79
≡AMLX – AMYLYX PHARMACEUTICALS INCAdd 13.29%1,050,0001.60
≡CNTA – CENTESSA PHARMACEUTICALS PLCAdd 170.36%1,953,9671.58
≡SOLENO THERAPEUTICS INCSell−430,439−1.30
≡PEN – PENUMBRA INCAdd 572.46%187,7501.27
≡PRAX – PRAXIS PRECISION MEDICINES IAdd 107.80%811,6331.20
≡ABVX – ABIVAX SABuy388,6080.93
≡XBIPUT – SPDR SERIES TRUSTSell−300,000−0.90
≡EOLS – EVOLUS INCSell−2,474,843−0.82
≡INBX – INHIBRX BIOSCIENCES INCAdd 35.77%349,8150.76
≡AORT – ARTIVION INCReduce 27.69%−773,703−0.73
≡EXACT SCIENCES CORPBuy465,4870.72
≡PVLA – PALVELLA THERAPEUTICS INC NEBuy395,0930.70
≡ORKA – ORUKA THERAPEUTICS INCBuy1,268,0210.69
≡PODD – INSULET CORPSell−60,387−0.69
≡BBNX – BETA BIONICS INCReduce 82.56%−1,315,664−0.68
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 226.79%1,014,8930.67
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 76.46%195,0000.63
≡IRTC – IRHYTHM TECHNOLOGIES INCBuy123,0000.60
≡DYN – DYNE THERAPEUTICS INCReduce 75.95%−1,706,946−0.58
≡CRL – CHARLES RIV LABS INTL INCSell−100,000−0.55
≡IMVT – IMMUNOVANT INCReduce 25.73%−550,000−0.51
≡INSM – INSMED INCAdd 7.98%51,8780.49
≡EWTX – EDGEWISE THERAPEUTICS INCReduce 18.19%−844,055−0.46
≡ZYME – ZYMEWORKS INCAdd 63.94%815,3890.43
≡ENGN – ENGENE HOLDINGS INCBuy2,097,2360.40
≡ADMA – ADMA BIOLOGICS INCReduce 11.51%−150,000−0.38
≡DRUG – BRIGHT MINDS BIOSCIENCES INCAdd 6.80%28,6000.37
≡RARE – ULTRAGENYX PHARMACEUTICAL INSell−270,000−0.35
≡APGE – APOGEE THERAPEUTICS INCAdd 14.37%169,841−0.34
≡RAPP – RAPPORT THERAPEUTICS INCBuy403,9230.34
≡AQST – AQUESTIVE THERAPEUTICS INCAdd 71.66%1,569,6790.33
≡CTMX – CYTOMX THERAPEUTICS INCAdd 38.41%2,686,5390.30
≡KOD – KODIAK SCIENCES INCBuy634,5770.29
≡VKTX – VIKING THERAPEUTICS INCReduce 72.26%−275,103−0.29
≡GOSS – GOSSAMER BIO INCBuy3,812,7970.28
≡RGEN – REPLIGEN CORPAdd 62.91%104,4280.27
≡CELCUITY INCBuy00.25
≡SYRE – SPYRE THERAPEUTICS INCReduce 19.61%−300,000−0.25
≡AKRO – AKERO THERAPEUTICS INCAdd 24.01%219,879−0.24
≡AXSM – AXSOME THERAPEUTICS INCReduce 25.00%−49,634−0.24
≡CAPRPUT – CAPRICOR THERAPEUTICS INCSell−650,000−0.23
≡BSX – BOSTON SCIENTIFIC CORPAdd 10.71%30,000−0.23
≡ISRG – INTUITIVE SURGICAL INCAdd 15.51%7,000−0.23
≡ALDX – ALDEYRA THERAPEUTICS INCAdd 28.89%1,170,6800.21
≡TEM – TEMPUS AI INCBuy85,0000.19
≡GMED – GLOBUS MED INCSell−88,500−0.19
≡KRYS – KRYSTAL BIOTECH INCBuy35,0000.17
≡BBOT – HELIX ACQUISITION CORP IISell−398,000−0.15
≡HTFL – HEARTFLOW INCBuy150,0000.14
≡NVNO – ENVVENO MEDICAL CORPORATIONAdd 36.89%474,069−0.14
≡AMICUS THERAPEUTICS INCReduce 14.06%−1,041,979−0.12
≡PEPG – PEPGEN INCBuy829,8700.11
≡BLTE – BELITE BIO INCBuy49,7880.10
≡ASND – ASCENDIS PHARMA A/SAdd 12.93%124,6150.10
≡NRIX – NURIX THERAPEUTICS INCAdd 29.09%319,164−0.08
≡OBIO – ORCHESTRA BIOMED HLDGS INCAdd 15.24%700,000−0.07
≡PYXS – PYXIS ONCOLOGY INCBuy1,178,3070.07
≡LONA – ATHIRA PHARMA INCBuy540,2960.06
≡KYMR – KYMERA THERAPEUTICS INCReduce 19.19%−40,310−0.06
≡ATHA 04/16/21 P15 – ATHIRA PHARMA INCSell−5,402,964−0.06
≡SPRYPUT – ARS PHARMACEUTICALS INCBuy200,0000.06
≡LYRA – LYRA THERAPEUTICS INCReduce 10.10%−25,768−0.04
≡CAPRCALL – CAPRICOR THERAPEUTICS INCSell−100,000−0.04
≡QURE – UNIQURE NVBuy20,0000.03
≡FBRX – FORTE BIOSCIENCES INCSell−68,192−0.03
≡SCPH – SCPHARMACEUTICALS INCAdd 16.63%83,1420.02
≡NUVL – NUVALENT INCAdd 13.61%187,1560.02
≡ANRO – ALTO NEUROSCIENCE INCBuy155,3660.02
≡KALA BIO INCSell−55,227−0.01
≡BDSX – BIODESIXReduce 95.00%−2,065,1860.00
EWTX – EDGEWISE THERAPEUTICS INC
Reduce 29.13%
−1,907,379
−2.89
≡SOLENO THERAPEUTICS INCReduce 71.43%−1,076,163−2.50
≡OMDA – OMADA HEALTH INCBuy2,426,3301.61
≡IOVA – IOVANCE BIOTHERAPEUTICS INCSell−12,711,788−1.50
≡ROIV – ROIVANT SCIENCES LTDBuy3,331,4651.36
≡MRUS 10/21/22 P30 – MERUS N VBuy708,1761.35
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 56.32%−5,224,220−1.32
≡ARGX – ARGENX SESell−59,510−1.24
≡CAI – CARIS LIFE SCIENCES INCBuy1,098,1631.06
≡MERUS N VSell−690,485−1.03
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 62.28%−1,893,460−1.00
≡INSM – INSMED INCAdd 27.68%140,9520.99
≡PCVX – VAXCYTE INCSell−706,567−0.94
≡EOLS – EVOLUS INCReduce 40.06%−1,654,299−0.93
≡XBIPUT – SPDR SERIES TRUSTBuy300,0000.90
≡ARCELLX INCReduce 15.32%−448,478−0.88
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 154.92%155,0000.77
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 5.11%−130,1460.76
≡AXSM – AXSOME THERAPEUTICS INCReduce 44.09%−156,573−0.71
≡JANX – JANUX THERAPEUTICS INCReduce 69.84%−677,726−0.68
≡AKRO – AKERO THERAPEUTICS INCAdd 15.50%122,9270.63
≡BSX – BOSTON SCIENTIFIC CORPAdd 115.38%150,0000.62
≡CTMX – CYTOMX THERAPEUTICS INCBuy6,993,6460.57
≡CRL – CHARLES RIV LABS INTL INCBuy100,0000.55
≡MDGL – MADRIGAL PHARMACEUTICALS INCSell−46,500−0.54
≡SYRE – SPYRE THERAPEUTICS INCReduce 33.88%−783,827−0.49
≡IMVT – IMMUNOVANT INCReduce 24.83%−706,182−0.48
≡TVTX – TRAVERE THERAPEUTICS INCBuy834,2520.45
≡DXCM – DEXCOM INCSell−178,000−0.43
≡EWTXCALL – EDGEWISE THERAPEUTICS INCSell−500,000−0.39
≡ACRV – ACRIVON THERAPEUTICS INCSell−5,360,858−0.38
≡APGE – APOGEE THERAPEUTICS INCAdd 5.29%59,3810.37
≡RARE – ULTRAGENYX PHARMACEUTICAL INBuy270,0000.35
≡CARGO THERAPEUTICS INCSell−2,431,085−0.35
≡KYMR – KYMERA THERAPEUTICS INCBuy210,1060.33
≡NRIX – NURIX THERAPEUTICS INCAdd 268.67%799,4320.33
≡PEN – PENUMBRA INCBuy32,7970.30
≡NUVL – NUVALENT INCReduce 15.84%−258,788−0.30
≡EYPT – EYEPOINT PHARMACEUTICALS INCSell−1,537,274−0.29
≡CBIO – CRESCENT BIOPHARMA INC.Buy453,6860.26
≡IRON – DISC MEDICINE INCSell−150,000−0.26
≡CTNM – CONTINEUM THERAPEUTICS INCReduce 51.47%−741,763−0.25
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORSell−930,972−0.24
≡OCUL – OCULAR THERAPEUTIX INCSell−915,775−0.24
≡CAPRPUT – CAPRICOR THERAPEUTICS INCBuy650,0000.23
≡CRVS – CORVUS PHARMACEUTICALS INCBuy1,438,5950.21
≡DCTH – DELCATH SYS INCSell−462,422−0.21
≡SEPN – SEPTERNA INCBuy541,4500.21
≡ZYME – ZYMEWORKS INCReduce 31.61%−589,398−0.21
≡RAPT THERAPEUTICS INCSell−4,418,947−0.19
≡GMED – GLOBUS MED INCBuy88,5000.19
≡NVNO – ENVVENO MEDICAL CORPORATIONBuy1,284,9660.19
≡KMTS – KESTRA MED TECHNOLOGIES LTDSell−200,000−0.18
≡ISRG – INTUITIVE SURGICAL INCAdd 11.08%4,5000.18
≡DRUG – BRIGHT MINDS BIOSCIENCES INCReduce 5.39%−23,959−0.17
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 23.24%−227,973−0.17
≡RGEN – REPLIGEN CORPAdd 27.89%36,1990.16
≡XENE – XENON PHARMACEUTICALS INCReduce 38.28%−124,533−0.16
≡OKUR – ONKURE THERAPEUTICS INCSell−1,004,439−0.15
≡AVTX – AVALO THERAPEUTICS INCReduce 73.14%−380,333−0.12
≡AQST – AQUESTIVE THERAPEUTICS INCReduce 41.23%−1,536,788−0.12
≡ADMA – ADMA BIOLOGICS INCReduce 5.08%−69,765−0.10
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 32.16%−212,155−0.09
≡IKT – INHIBIKASE THERAPEUTICS INCReduce 8.32%−492,707−0.08
≡MREO – MEREO BIOPHARMA GROUP PLCSell−876,961−0.07
≡VKTX – VIKING THERAPEUTICS INCReduce 25.21%−128,305−0.07
≡ATHA 04/16/21 P15 – ATHIRA PHARMA INCBuy5,402,9640.06
≡CELC – CELCUITY INCReduce 30.86%−729,071−0.06
≡ATHIRA PHARMA INCSell−5,402,964−0.05
≡RAPT THERAPEUTICS INCBuy183,8900.05
≡KALA BIO INCReduce 80.11%−222,383−0.05
≡TRIB – TRINITY BIOTECH PLCBuy1,790,0000.04
≡AVR – ANTERIS TECHNOLOGIES GLOBALReduce 20.32%−434,870−0.04
≡CAPRCALL – CAPRICOR THERAPEUTICS INCBuy100,0000.04
≡TRAW – TRAWS PHARMA INCSell−421,781−0.03
≡RCKT – ROCKET PHARMACEUTICALS INCSell−140,726−0.03
≡FBRX – FORTE BIOSCIENCES INCBuy68,1920.03
≡LYRA – LYRA THERAPEUTICS INCReduce 98.00%−12,502,4120.03
≡PODD – INSULET CORPReduce 15.66%−11,2100.02
≡CGEM – CULLINAN THERAPEUTICS INCSell−80,100−0.02
≡INBX – INHIBRX BIOSCIENCES INCReduce 8.10%−86,134−0.02
≡APLT – APPLIED THERAPEUTICS INCSell−860,000−0.01
≡NBTX – NANOBIOTIXSell−105,053−0.01
−1.48
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 26.23%−348,841−1.47
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 52.11%−3,308,825−1.35
≡INSM – INSMED INCAdd 253.68%365,3001.10
≡CARGO THERAPEUTICS INCReduce 33.99%−1,251,919−1.09
≡PRAXCALL – PRAXIS PRECISION MEDICINES ISell−500,000−1.05
≡MERUS N VBuy690,4851.03
≡PODD – INSULET CORPReduce 69.17%−160,672−0.98
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 30.76%−1,132,028−0.83
≡SLDB – SOLID BIOSCIENCES INCAdd 72.39%5,000,0000.81
≡INTRA-CELLULAR THERAPIES INCReduce 38.96%−501,9700.74
≡BBNX – BETA BIONICS INCBuy1,593,6080.69
≡VKTX – VIKING THERAPEUTICS INCReduce 48.89%−486,889−0.66
≡PRCT – PROCEPT BIOROBOTICS CORPSell−290,659−0.64
≡RGEN – REPLIGEN CORPBuy129,8010.58
≡ADMA – ADMA BIOLOGICS INCAdd 54.25%482,9530.55
≡MDGL – MADRIGAL PHARMACEUTICALS INCBuy46,5000.54
≡NTRA – NATERA INCSell−125,000−0.54
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 14.19%−180,3910.53
≡DYN – DYNE THERAPEUTICS INCAdd 325.82%1,770,1260.51
≡PEN – PENUMBRA INCSell−73,338−0.47
≡ARCELLX INCReduce 15.88%−552,410−0.47
≡SEPN – SEPTERNA INCSell−750,000−0.47
≡BSX – BOSTON SCIENTIFIC CORPBuy130,0000.46
≡SION – SIONNA THERAPEUTICS INCBuy1,251,1010.46
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 55.62%−826,846−0.46
≡ORKA – ORUKA THERAPEUTICS INCSell−845,567−0.45
≡DXCM – DEXCOM INCBuy178,0000.43
≡EWTXCALL – EDGEWISE THERAPEUTICS INCBuy500,0000.39
≡ARVN – ARVINAS INCSell−740,749−0.39
≡AQST – AQUESTIVE THERAPEUTICS INCBuy3,727,2080.38
≡MRUS 10/21/22 P30 – MERUS N VSell−300,000−0.34
≡CGON – CG ONCOLOGY INCSell−419,450−0.33
≡OM – OUTSET MED INCBuy833,3330.33
≡SYRE – SPYRE THERAPEUTICS INCReduce 10.15%−261,451−0.31
≡EW – EDWARDS LIFESCIENCES CORPSell−145,000−0.29
≡AMLX – AMYLYX PHARMACEUTICALS INCAdd 16.24%1,100,0000.29
≡TARS – TARSUS PHARMACEUTICALS INCSell−186,662−0.28
≡IMVT – IMMUNOVANT INCAdd 32.95%704,8730.28
≡JANX – JANUX THERAPEUTICS INCAdd 18.65%152,517−0.27
≡IRON – DISC MEDICINE INCBuy150,0000.26
≡CRNX – CRINETICS PHARMACEUTICALS INSell−184,525−0.26
≡RAPT 05/21/21 C35 – RAPT THERAPEUTICS INCSell−5,880,000−0.25
≡INARI MED INCSell−178,797−0.25
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORBuy930,9720.24
≡AKRO – AKERO THERAPEUTICS INCReduce 33.12%−392,6320.24
≡EOLS – EVOLUS INCReduce 19.76%−1,016,7040.21
≡APGE – APOGEE THERAPEUTICS INCAdd 7.21%75,5350.19
≡DCTH – DELCATH SYS INCAdd 824.84%412,4220.19
≡RAPT THERAPEUTICS INCBuy4,418,9470.19
≡ISRG – INTUITIVE SURGICAL INCReduce 35.65%−22,500−0.19
≡KMTS – KESTRA MED TECHNOLOGIES LTDBuy200,0000.18
≡DRUG – BRIGHT MINDS BIOSCIENCES INCAdd 10.16%41,0000.17
≡ZBIO – ZENAS BIOPHARMA INCSell−744,035−0.17
≡IRTC – IRHYTHM TECHNOLOGIES INCSell−65,153−0.16
≡RAPP – RAPPORT THERAPEUTICS INCSell−311,551−0.15
≡IRD – OPUS GENETICS INCBuy4,325,0000.15
≡AVTX – AVALO THERAPEUTICS INCBuy520,0000.15
≡CBLL – CERIBELL INCSell−180,546−0.13
≡ARGX – ARGENX SEReduce 11.80%−7,9610.12
≡VERU – VERU INCSell−6,483,157−0.11
≡CATX – PERSPECTIVE THERAPEUTICS INCSell−1,190,263−0.10
≡LCTX – LINEAGE CELL THERAPEUTICS INSell−7,236,843−0.10
≡RCKT – ROCKET PHARMACEUTICALS INCReduce 62.83%−237,858−0.10
≡ATHA 04/16/21 P15 – ATHIRA PHARMA INCSell−5,402,964−0.09
≡PEPG – PEPGEN INCSell−829,536−0.09
≡IBRX – IMMUNITYBIO INCSell−1,221,734−0.09
≡BCYC – BICYCLE THERAPEUTICS PLCSell−197,108−0.08
≡AXSM – AXSOME THERAPEUTICS INCReduce 46.53%−308,967−0.06
≡ZYME – ZYMEWORKS INCReduce 12.46%−265,348−0.06
≡VRCA – VERRICA PHARMACEUTICALS INCSell−3,249,669−0.06
≡FBRX – FORTE BIOSCIENCES INCSell−95,742−0.06
≡KALA BIO INCBuy277,6100.06
≡ATHIRA PHARMA INCBuy5,402,9640.05
≡NRIX – NURIX THERAPEUTICS INCReduce 10.00%−33,061−0.04
≡TRIB – TRINITY BIOTECH PLCSell−1,790,000−0.04
≡MREO – MEREO BIOPHARMA GROUP PLCReduce 19.21%−208,551−0.03
≡FULC – FULCRUM THERAPEUTICS INCSell−238,000−0.03
≡AMICUS THERAPEUTICS INCReduce 11.47%−2,781,425−0.02
≡NVAXPUT – NOVAVAX INCSell−100,000−0.02
≡CGEM – CULLINAN THERAPEUTICS INCBuy80,1000.02
≡BBOT – HELIX ACQUISITION CORP IIReduce 20.40%−102,0000.02
≡OCUL – OCULAR THERAPEUTIX INCReduce 15.09%−162,720−0.01
≡PYXS – PYXIS ONCOLOGY INCSell−188,462−0.01
≡NBTX – NANOBIOTIXReduce 60.52%−161,040−0.01
≡TRAW – TRAWS PHARMA INCAdd 156.94%257,624−0.01
≡APGE – APOGEE THERAPEUTICS INCReduce 48.03%−967,775−1.21
≡JANX – JANUX THERAPEUTICS INCBuy817,8951.19
≡VKTX – VIKING THERAPEUTICS INCReduce 41.42%−704,093−1.19
≡PCVX – VAXCYTE INCReduce 15.25%−309,191−1.07
≡PRAXCALL – PRAXIS PRECISION MEDICINES IBuy500,0001.05
≡PODD – INSULET CORPAdd 63.26%90,0000.95
≡NUVL – NUVALENT INCReduce 12.06%−359,258−0.87
≡XBIPUT – SPDR SER TRSell−400,000−0.84
≡IOVA – IOVANCE BIOTHERAPEUTICS INCReduce 16.93%−4,505,443−0.84
≡EWTX – EDGEWISE THERAPEUTICS INCAdd 15.24%355,2430.63
≡TARS – TARSUS PHARMACEUTICALS INCReduce 85.60%−1,109,754−0.62
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 47.15%−1,326,157−0.58
≡AMLX – AMYLYX PHARMACEUTICALS INCAdd 218.70%4,648,6990.55
≡CRNX – CRINETICS PHARMACEUTICALS INReduce 74.54%−540,173−0.53
≡IKT – INHIBIKASE THERAPEUTICS INCBuy5,925,0000.52
≡TIL – INSTIL BIO INCSell−345,545−0.49
≡LIVN – LIVANOVA PLCSell−429,000−0.48
≡PEN – PENUMBRA INCBuy73,3380.47
≡SPRINGWORKS THERAPEUTICS INCSell−692,263−0.47
≡MDT – MEDTRONIC PLCSell−245,332−0.47
≡SEPN – SEPTERNA INCBuy750,0000.47
≡INTRA-CELLULAR THERAPIES INCReduce 20.58%−333,8870.42
≡IRON – DISC MEDICINE INCSell−387,017−0.40
≡DRUG – BRIGHT MINDS BIOSCIENCES INCBuy403,6490.40
≡ARCELLX INCReduce 10.54%−409,7810.39
≡OCUL – OCULAR THERAPEUTIX INCReduce 67.56%−2,245,973−0.36
≡MRUS 10/21/22 P30 – MERUS N VBuy300,0000.34
≡AVR – ANTERIS TECHNOLOGIES GLOBALBuy2,140,0000.32
≡MERUS N VSell−300,000−0.32
≡ISRG – INTUITIVE SURGICAL INCAdd 8.60%5,0000.29
≡EW – EDWARDS LIFESCIENCES CORPBuy145,0000.29
≡ICLR – ICON PLCSell−44,353−0.27
≡ARQT – ARCUTIS BIOTHERAPEUTICS INCSell−1,358,500−0.27
≡CGON – CG ONCOLOGY INCReduce 42.83%−314,245−0.26
≡TYRA – TYRA BIOSCIENCES INCSell−511,226−0.25
≡RAPT 05/21/21 C35 – RAPT THERAPEUTICS INCBuy5,880,0000.25
≡INARI MED INCBuy178,7970.25
≡ZBIO – ZENAS BIOPHARMA INCReduce 34.96%−400,000−0.24
≡OKUR – ONKURE THERAPEUTICS INCBuy1,004,4390.23
≡RCKT – ROCKET PHARMACEUTICALS INCReduce 59.37%−553,267−0.23
≡ARGX – ARGENX SEReduce 43.22%−51,368−0.23
≡XNCR – XENCOR INCSell−527,671−0.22
≡ROIV – ROIVANT SCIENCES LTDSell−847,745−0.21
≡AVBP – ARRIVENT BIOPHARMA INCSell−415,000−0.21
≡DYN – DYNE THERAPEUTICS INCReduce 24.35%−174,867−0.20
≡ORKA – ORUKA THERAPEUTICS INCReduce 31.54%−389,620−0.19
≡EXACT SCIENCES CORPSell−125,000−0.18
≡RAPP – RAPPORT THERAPEUTICS INCReduce 58.36%−436,632−0.17
≡PEPG – PEPGEN INCReduce 41.19%−580,902−0.17
≡NRIX – NURIX THERAPEUTICS INCBuy330,6140.17
≡ALLO – ALLOGENE THERAPEUTICS INCSell−2,725,000−0.16
≡SYRE – SPYRE THERAPEUTICS INCReduce 10.37%−297,824−0.16
≡VRCA – VERRICA PHARMACEUTICALS INCReduce 54.22%−3,849,513−0.16
≡VERONA PHARMA PLCSell−250,000−0.15
≡VERONA PHARMA PLCSell−250,000−0.15
≡ARVN – ARVINAS INCReduce 27.93%−287,000−0.15
≡NBIX – NEUROCRINE BIOSCIENCESReduce 52.86%−112,178−0.15
≡AKRO – AKERO THERAPEUTICS INCReduce 30.86%−529,214−0.14
≡IMTX – IMMATICS N.VAdd 16.04%1,297,297−0.14
≡EYPT – EYEPOINT PHARMACEUTICALS INCAdd 48.20%500,0000.14
≡CBLL – CERIBELL INCBuy180,5460.13
≡AMICUS THERAPEUTICS INCReduce 13.58%−3,811,504−0.13
≡IRTC – IRHYTHM TECHNOLOGIES INCAdd 188.40%42,5620.12
≡FLNAPUT – CASSAVA SCIENCES INCSell−183,000−0.11
≡FULCCALL – FULCRUM THERAPEUTICS INCSell−1,500,000−0.11
≡CATX – PERSPECTIVE THERAPEUTICS INCBuy1,190,2630.10
≡PRCT – PROCEPT BIOROBOTICS CORPReduce 7.92%−25,0000.10
≡LCTX – LINEAGE CELL THERAPEUTICS INBuy7,236,8430.10
≡XENE – XENON PHARMACEUTICALS INCReduce 38.03%−199,606−0.09
≡ATHA 04/16/21 P15 – ATHIRA PHARMA INCBuy5,402,9640.09
≡IBRX – IMMUNITYBIO INCBuy1,221,7340.09
≡DTIL – PRECISION BIOSCIENCES INCSell−426,293−0.08
≡ABSI – ABSCI CORPORATIONSell−700,000−0.06
≡NTRA – NATERA INCReduce 43.18%−95,000−0.05
≡ATHIRA PHARMA INCSell−5,402,964−0.05
≡X4 PHARMACEUTICALS INCSell−3,545,454−0.05
≡NVNO – ENVVENO MEDICAL CORPORATIONSell−694,315−0.05
≡SCPH – SCPHARMACEUTICALS INCBuy500,0000.05
≡BCYC – BICYCLE THERAPEUTICS PLCReduce 23.00%−58,886−0.05
≡NBTX – NANOBIOTIXReduce 52.06%−288,973−0.05
≡KYMR – KYMERA THERAPEUTICS INCSell−46,213−0.05
≡AXSM – AXSOME THERAPEUTICS INCReduce 15.17%−118,7700.04
≡TRAW – TRAWS PHARMA INCBuy164,1570.04
≡ADMA – ADMA BIOLOGICS INCReduce 16.03%−169,920−0.03
≡MREO – MEREO BIOPHARMA GROUP PLCAdd 33.07%269,7900.03
≡GPCR – STRUCTURE THERAPEUTICS INCSell−34,852−0.03
≡PYXS – PYXIS ONCOLOGY INCReduce 62.93%−320,000−0.03
≡FULC – FULCRUM THERAPEUTICS INCBuy238,0000.03
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 7.49%−102,9010.03
≡FATE – FATE THERAPEUTICS INCSell−345,575−0.03
≡ENSC – ENSYSCE BIOSCIENCES INCBuy86,6660.02
≡SINGULAR GENOMICS SYSTEMS INSell−50,896−0.02
≡DCTH – DELCATH SYS INCBuy50,0000.02
≡KYTX – KYVERNA THERAPEUTICS INCSell−150,000−0.02
≡INSM – INSMED INCReduce 20.00%−36,000−0.01
≡IMVT – IMMUNOVANT INCReduce 10.07%−239,5630.01
≡APYX – APYX MEDICAL CORPORATIONBuy150,0000.01
≡SYRS – SYROS PHARMACEUTICALS INCSell−116,754−0.01
≡VERU – VERU INCReduce 10.98%−800,000−0.00
≡CAREMAX INCSell−100,000−0.00
≡CAREMAX INCSell−60,000−0.00
≡
NBIX – NEUROCRINE BIOSCIENCES INC
Reduce 67.34%
−437,681
−1.64
≡PCVX – VAXCYTE INCAdd 8.86%165,0001.51
≡VKTX – VIKING THERAPEUTICS INCAdd 135.66%978,6101.35
≡CNTA – CENTESSA PHARMACEUTICALS PLCAdd 59.72%2,348,9831.27
≡ARGX – ARGENX SEAdd 661.79%103,2391.20
≡SPRINGWORKS THERAPEUTICS INCReduce 58.12%−960,699−1.03
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 72.36%1,180,8370.84
≡XBIPUT – SPDR SER TRBuy400,0000.84
≡CRNX – CRINETICS PHARMACEUTICALS INReduce 50.91%−751,505−0.81
≡NTRA – NATERA INCReduce 58.49%−310,000−0.79
≡BBIO – BRIDGEBIO PHARMA INCSell−1,215,346−0.74
≡PODD – INSULET CORPBuy142,2690.70
≡PRAX – PRAXIS PRECISION MEDICINES IAdd 55.16%413,8050.67
≡ORKA – ORUKA THERAPEUTICS INCBuy1,235,1870.64
≡AXSM – AXSOME THERAPEUTICS INCAdd 70.51%323,7330.60
≡DYN – DYNE THERAPEUTICS INCBuy718,1440.55
≡ADGM – ADAGIO MED HLDGS INCBuy9,812,4190.54
≡EWTX – EDGEWISE THERAPEUTICS INCAdd 25.53%473,8770.51
≡TIL – INSTIL BIO INCBuy345,5450.49
≡MDT – MEDTRONIC PLCReduce 50.00%−245,333−0.46
≡ZBIO – ZENAS BIOPHARMA INCBuy1,144,0350.41
≡EOLS – EVOLUS INCReduce 6.90%−397,1760.33
≡INTRA-CELLULAR THERAPIES INCReduce 5.49%−94,192−0.32
≡CGEM – CULLINAN THERAPEUTICS INCSell−749,916−0.32
≡ADMA – ADMA BIOLOGICS INCReduce 61.74%−1,710,800−0.30
≡RCKT – ROCKET PHARMACEUTICALS INCReduce 25.25%−314,746−0.28
≡PTGX – PROTAGONIST THERAPEUTICS INCAdd 8.34%105,8280.25
≡ZYME – ZYMEWORKS INCAdd 30.72%512,3090.24
≡TEM – TEMPUS AI INCSell−275,000−0.23
≡PRCT – PROCEPT BIOROBOTICS CORPAdd 49.84%105,0000.22
≡XNCR – XENCOR INCBuy527,6710.22
≡IMVT – IMMUNOVANT INCAdd 23.65%454,9760.21
≡ROIV – ROIVANT SCIENCES LTDBuy847,7450.21
≡IRON – DISC MEDICINE INCReduce 30.07%−166,420−0.20
≡AKRO – AKERO THERAPEUTICS INCAdd 14.33%214,9090.19
≡ENGN – ENGENE HOLDINGS INCSell−800,000−0.18
≡EXACT SCIENCES CORPBuy125,0000.18
≡SPRY – ARS PHARMACEUTICALS INCSell−867,319−0.18
≡BCYC – BICYCLE THERAPEUTICS PLCReduce 55.25%−316,006−0.16
≡VERONA PHARMA PLCBuy250,0000.15
≡VERONA PHARMA PLCBuy250,0000.15
≡AMLX – AMYLYX PHARMACEUTICALS INCBuy2,125,6490.15
≡KALVISTA PHARMACEUTICALS INCSell−500,000−0.14
≡RXRX – RECURSION PHARMACEUTICALS INSell−769,230−0.14
≡TYRA – TYRA BIOSCIENCES INCReduce 49.25%−496,141−0.13
≡IMVTCALL – IMMUNOVANT INCSell−200,000−0.13
≡FULCCALL – FULCRUM THERAPEUTICS INCBuy1,500,0000.11
≡XENE – XENON PHARMACEUTICALS INCReduce 10.00%−58,326−0.11
≡CABA – CABALETTA BIO INCSell−585,045−0.11
≡SKYE – SKYE BIOSCIENCE INCSell−500,000−0.10
≡ARQT – ARCUTIS BIOTHERAPEUTICS INCReduce 12.83%−200,000−0.08
≡FHTX – FOGHORN THERAPEUTICS INCSell−544,000−0.08
≡SYRE – SPYRE THERAPEUTICS INCReduce 5.23%−158,4710.07
≡ISRG – INTUITIVE SURGICAL INCReduce 5.96%−3,681−0.06
≡IRTC – IRHYTHM TECHNOLOGIES INCReduce 35.83%−12,614−0.06
≡XBI – SPDR SER TRSell−22,665−0.05
≡KYMR – KYMERA THERAPEUTICS INCBuy46,2130.05
≡EYPT – EYEPOINT PHARMACEUTICALS INCAdd 62.00%397,0000.04
≡PYXS – PYXIS ONCOLOGY INCBuy508,4620.04
≡MGTX – MEIRAGTX HLDGS PLCAdd 11.03%1,250,000−0.04
≡MREO – MEREO BIOPHARMA GROUP PLCReduce 34.91%−437,528−0.04
≡REVANCE THERAPEUTICS INCSell−600,000−0.04
≡ICLR – ICON PLCAdd 41.93%13,1030.03
≡FBRX – FORTE BIOSCIENCES INCReduce 97.07%−3,169,617−0.03
≡NVNO – ENVVENO MEDICAL CORPORATIONAdd 11.39%71,000−0.03
≡LXEO – LEXEO THERAPEUTICS INCBuy139,8350.03
≡EGRX – EAGLE PHARMACEUTICALS INCSell−173,365−0.02
≡VBI VACCINES INC CDASell−1,261,710−0.02
≡TCMD – TACTILE SYS TECHNOLOGY INCSell−62,639−0.02
≡AXGN – AXOGEN INCSell−30,421−0.01
≡CAREMAX INCReduce 18.46%−22,643−0.00
≡SINGULAR GENOMICS SYSTEMS INReduce 28.21%−20,0000.00
≡OBIO – ORCHESTRA BIOMED HLDGS INCAdd 80.39%2,046,675−0.00
≡
MDT – MEDTRONIC PLC
Reduce 65.68%
−938,898
−1.25
≡SRPT – SAREPTA THERAPEUTICS INCSell−525,683−1.19
≡NUVL – NUVALENT INCReduce 8.42%−234,3771.00
≡RYTM – RHYTHM PHARMACEUTICALS INCAdd 5.45%178,0000.93
≡CTNM – CONTINEUM THERAPEUTICS INCBuy1,566,6680.66
≡AXSM – AXSOME THERAPEUTICS INCReduce 58.46%−646,230−0.65
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 55.38%−2,025,271−0.61
≡LANDOS BIOPHARMA INCSell−1,486,991−0.56
≡PTGX – PROTAGONIST THERAPEUTICS INCAdd 27.60%274,4120.56
≡TMCI – TREACE MED CONCEPTS INCSell−2,304,954−0.53
≡VKTX – VIKING THERAPEUTICS INCReduce 27.43%−272,721−0.51
≡AUTL – AUTOLUS THERAPEUTICS PLCSell−4,330,745−0.48
≡IMVT – IMMUNOVANT INCReduce 35.08%−1,039,426−0.45
≡SPRINGWORKS THERAPEUTICS INCReduce 26.94%−609,500−0.45
≡CGON – CG ONCOLOGY INCReduce 43.74%−570,410−0.44
≡MERUS N VBuy300,0000.43
≡IRON – DISC MEDICINE INCReduce 41.12%−386,429−0.42
≡RAPP – RAPPORT THERAPEUTICS INCBuy748,1830.42
≡BHVN – BIOHAVEN LTDReduce 13.90%−239,815−0.41
≡CABA – CABALETTA BIO INCReduce 65.92%−1,131,615−0.41
≡IRTC – IRHYTHM TECHNOLOGIES INCReduce 85.64%−210,000−0.41
≡ACRV – ACRIVON THERAPEUTICS INCAdd 78.23%2,353,0000.37
≡RVMD – REVOLUTION MEDICINES INCSell−618,885−0.35
≡ABBV – ABBVIE INCSell−106,500−0.34
≡IRONPUT – DISC MEDICINE INCSell−300,000−0.33
≡CGEM – CULLINAN THERAPEUTICS INCBuy749,9160.32
≡MLTX – MOONLAKE IMMUNOTHERAPEUTICSSell−339,012−0.30
≡LIVN – LIVANOVA PLCAdd 48.49%145,0000.29
≡INSM – INSMED INCBuy180,0000.29
≡BCYC – BICYCLE THERAPEUTICS PLCBuy572,0000.28
≡ALDX – ALDEYRA THERAPEUTICS INCAdd 7.94%682,2650.25
≡CNTA – CENTESSA PHARMACEUTICALS PLCAdd 27.57%850,0000.25
≡TCMD – TACTILE SYS TECHNOLOGY INCReduce 93.06%−840,446−0.24
≡ICLR – ICON PLCBuy31,2500.24
≡AKRO – AKERO THERAPEUTICS INCAdd 8.10%112,4260.23
≡ARVN – ARVINAS INCReduce 16.89%−208,854−0.23
≡TEM – TEMPUS AI INCBuy275,0000.23
≡MDGL – MADRIGAL PHARMACEUTICALS INCReduce 38.46%−165,353−0.22
≡ARQT – ARCUTIS BIOTHERAPEUTICS INCAdd 107.80%808,5000.22
≡AXGN – AXOGEN INCReduce 98.04%−1,523,508−0.21
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 19.21%−154,5000.21
≡VERONA PHARMA PLCReduce 35.30%−1,327,851−0.21
≡RCKT – ROCKET PHARMACEUTICALS INCReduce 30.79%−554,471−0.20
≡TYRA – TYRA BIOSCIENCES INCAdd 50.54%338,2080.20
≡RAPT THERAPEUTICS INCSell−1,223,472−0.19
≡MORPHIC HLDG INCSell−288,221−0.18
≡NTRA – NATERA INCReduce 30.01%−227,2250.17
≡ARGX – ARGENX SEBuy15,6000.16
≡ALLO – ALLOGENE THERAPEUTICS INCBuy2,725,0000.15
≡ZYME – ZYMEWORKS INCAdd 55.16%592,9040.14
≡RXRX – RECURSION PHARMACEUTICALS INBuy769,2300.14
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 8.69%−71,359−0.13
≡XENE – XENON PHARMACEUTICALS INCReduce 34.63%−308,952−0.12
≡ENGN – ENGENE HOLDINGS INCReduce 19.91%−198,888−0.11
≡CARGO THERAPEUTICS INCAdd 6.82%235,0000.11
≡MREO – MEREO BIOPHARMA GROUP PLCBuy1,253,2500.11
≡COGT – COGENT BIOSCIENCES INCSell−883,333−0.10
≡IBRX – IMMUNITYBIO INCSell−1,052,887−0.10
≡MGNX – MACROGENICS INCSell−378,327−0.10
≡SKYE – SKYE BIOSCIENCE INCBuy500,0000.10
≡AMLXCALL – AMYLYX PHARMACEUTICALS INCSell−1,679,125−0.08
≡XBIPUT – SPDR SER TRSell−50,000−0.08
≡BDSX – BIODESIX INCBuy2,173,8800.08
≡EYPT – EYEPOINT PHARMACEUTICALS INCAdd 8.59%50,628−0.08
≡FHTX – FOGHORN THERAPEUTICS INCBuy544,0000.08
≡VERU – VERU INCAdd 26.48%1,478,5780.07
≡ESTA – ESTABLISHMENT LABS HLDGS INCSell−82,299−0.07
≡NAMS – NEWAMSTERDAM PHARMA COMPANYSell−175,000−0.07
≡IMVTCALL – IMMUNOVANT INCAdd 100.00%100,0000.07
≡EWTX – EDGEWISE THERAPEUTICS INCReduce 19.97%−463,2290.07
≡APLTCALL – APPLIED THERAPEUTICS INCSell−500,000−0.06
≡FLNAPUT – CASSAVA SCIENCES INCBuy183,0000.05
≡AGIOCALL – AGIOS PHARMACEUTICALS INCSell−100,000−0.05
≡XBI – SPDR SER TRBuy22,6650.05
≡ISRG – INTUITIVE SURGICAL INCReduce 39.29%−40,000−0.05
≡GPCR – STRUCTURE THERAPEUTICS INCBuy34,8520.03
≡NVAXPUT – NOVAVAX INCReduce 85.71%−600,000−0.03
≡FATE – FATE THERAPEUTICS INCBuy345,5750.03
≡EGRX – EAGLE PHARMACEUTICALS INCBuy173,3650.02
≡BBIO – BRIDGEBIO PHARMA INCReduce 13.93%−196,687−0.02
≡SYRE – SPYRE THERAPEUTICS INCAdd 18.55%474,3390.02
≡SINGULAR GENOMICS SYSTEMS INSell−2,126,893−0.02
≡KURA – KURA ONCOLOGY INCSell−48,200−0.02
≡AMLX – AMYLYX PHARMACEUTICALS INCSell−300,000−0.01
≡SINGULAR GENOMICS SYSTEMS INBuy70,8960.01
≡DTIL – PRECISION BIOSCIENCES INCReduce 11.28%−54,190−0.01
≡IOVA – IOVANCE BIOTHERAPEUTICS INCAdd 34.56%6,660,1510.01
≡ADMA – ADMA BIOLOGICS INCReduce 56.93%−3,662,3690.00
≡
VKTX – VIKING THERAPEUTICS INC
Buy
994,098
1.43
≡APGE – APOGEE THERAPEUTICS INCAdd 12.72%232,4941.26
≡MDGL – MADRIGAL PHARMACEUTICALS INCAdd 184.45%278,8021.23
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 197.06%533,6151.14
≡SLDB – SOLID BIOSCIENCES INCAdd 97.56%3,410,7131.13
≡INTRA-CELLULAR THERAPIES INCAdd 877.18%947,3551.11
≡RAYZEBIO INCSell−744,056−1.03
≡CGON – CG ONCOLOGY INCBuy1,304,1051.00
≡RAPT THERAPEUTICS INCReduce 42.83%−916,478−0.99
≡ASTRIA THERAPEUTICS INCAdd 61.97%2,481,3500.91
≡PRAX – PRAXIS PRECISION MEDICINES IBuy821,5890.88
≡ARCELLX INCReduce 13.45%−611,253−0.84
≡BBIO – BRIDGEBIO PHARMA INCReduce 19.26%−336,900−0.81
≡PCVX – VAXCYTE INCAdd 77.56%844,2730.78
≡APLT – APPLIED THERAPEUTICS INCAdd 96.19%3,924,7510.65
≡AORT – ARTIVION INCAdd 186.57%1,737,6260.62
≡CNTA – CENTESSA PHARMACEUTICALS PLCBuy3,083,3070.61
≡EWTX – EDGEWISE THERAPEUTICS INCAdd 317.54%1,764,0910.60
≡AMLX – AMYLYX PHARMACEUTICALS INCReduce 83.95%−1,569,125−0.60
≡ARVN – ARVINAS INCAdd 249.24%882,5210.57
≡OCUL – OCULAR THERAPEUTIX INCBuy3,324,4680.53
≡IMVT – IMMUNOVANT INCAdd 27.28%635,130−0.51
≡CABA – CABALETTA BIO INCReduce 14.30%−286,398−0.50
≡IRTC – IRHYTHM TECHNOLOGIES INCBuy245,2050.50
≡ABBV – ABBVIE INCReduce 55.25%−131,500−0.48
≡EOLS – EVOLUS INCAdd 45.17%1,790,3740.48
≡XENE – XENON PHARMACEUTICALS INCReduce 18.95%−208,540−0.46
≡CELC – CELCUITY INCAdd 59.47%880,9790.41
≡MDT – MEDTRONIC PLCAdd 46.37%452,9110.38
≡ASND – ASCENDIS PHARMAA/SSell−132,176−0.37
≡PEPG – PEPGEN INCBuy1,410,4380.36
≡SPRINGWORKS THERAPEUTICS INCAdd 15.59%305,2160.35
≡MIRM – MIRUM PHARMACEUTICALS INCSell−534,942−0.35
≡IRONPUT – DISC MEDICINE INCBuy300,0000.33
≡PTGX – PROTAGONIST THERAPEUTICS INCAdd 159.44%611,0630.31
≡AXSM – AXSOME THERAPEUTICS INCAdd 6.49%67,322−0.30
≡ISRG – INTUITIVE SURGICAL INCAdd 85.09%46,8000.30
≡ENGN – ENGENE HOLDINGS INCBuy998,8880.30
≡IRON – DISC MEDICINE INCReduce 8.13%−83,179−0.30
≡RCKT – ROCKET PHARMACEUTICALS INCAdd 5.49%93,670−0.29
≡LIVN – LIVANOVA PLCBuy299,0000.29
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 111.37%1,926,8870.28
≡RYTM – RHYTHM PHARMACEUTICALS INCAdd 51.74%1,114,4690.27
≡TNGX – TANGO THERAPEUTICS INCSell−1,111,870−0.25
≡AUTL – AUTOLUS THERAPEUTICS PLCAdd 136.50%2,499,5780.22
≡SRPT – SAREPTA THERAPEUTICS INCAdd 16.33%73,8100.22
≡CRNX – CRINETICS PHARMACEUTICALS INAdd 17.58%220,6910.21
≡MLTX – MOONLAKE IMMUNOTHERAPEUTICSAdd 311.43%256,6140.19
≡PRCT – PROCEPT BIOROBOTICS CORPBuy210,6590.18
≡RVMD – REVOLUTION MEDICINES INCReduce 24.42%−199,997−0.18
≡TMCI – TREACE MED CONCEPTS INCAdd 84.34%1,054,5490.17
≡OLMA – OLEMA PHARMACEUTICALS INCSell−539,831−0.17
≡TERNS PHARMACEUTICALS INCSell−1,075,000−0.16
≡SPRY – ARS PHARMACEUTICALS INCBuy867,3190.16
≡MORPHIC HLDG INCAdd 405.83%231,2410.14
≡RGNX – REGENXBIO INCSell−342,408−0.14
≡ARQT – ARCUTIS BIOTHERAPEUTICS INCBuy750,0000.13
≡AVBP – ARRIVENT BIOPHARMA INCBuy415,0000.13
≡DTIL – PRECISION BIOSCIENCES INCBuy480,4830.11
≡AKRO – AKERO THERAPEUTICS INCAdd 43.37%419,6960.11
≡KALVISTA PHARMACEUTICALS INCBuy500,0000.10
≡IBRX – IMMUNITYBIO INCBuy1,052,8870.10
≡AXGN – AXOGEN INCAdd 92.23%745,5490.10
≡BBOT – HELIX ACQUISITION CORP IIBuy500,0000.09
≡AMLXCALL – AMYLYX PHARMACEUTICALS INCBuy1,679,1250.08
≡TYRA – TYRA BIOSCIENCES INCAdd 85.88%309,1590.08
≡TVTX – TRAVERE THERAPEUTICS INCSell−400,000−0.08
≡NAMS – NEWAMSTERDAM PHARMA COMPANYBuy175,0000.07
≡ACAD – ACADIA PHARMACEUTICALS INCSell−101,000−0.07
≡ABSI – ABSCI CORPORATIONBuy700,0000.07
≡KYTX – KYVERNA THERAPEUTICS INCBuy150,0000.07
≡TRIB – TRINITY BIOTECH PLCBuy1,800,0000.06
≡IMVTCALL – IMMUNOVANT INCBuy100,0000.06
≡CYTK – CYTOKINETICS INCSell−30,317−0.06
≡XBIPUT – SPDR SER TRReduce 97.37%−1,850,0000.05
≡REVANCE THERAPEUTICS INCBuy600,0000.05
≡AGIOCALL – AGIOS PHARMACEUTICALS INCBuy100,0000.05
≡KRONOS BIO INCSell−1,752,745−0.05
≡NVAXPUT – NOVAVAX INCReduce 50.00%−700,000−0.05
≡COGT – COGENT BIOSCIENCES INCReduce 21.34%−239,625−0.04
≡CAREMAX INCSell−3,679,284−0.04
≡MGNX – MACROGENICS INCReduce 38.17%−233,605−0.03
≡TCMD – TACTILE SYS TECHNOLOGY INCAdd 27.71%195,9260.03
≡AMBRX BIOPHARMA INCSell−78,811−0.03
≡NTRA – NATERA INCReduce 10.94%−93,0000.02
≡IMTX – IMMATICS N.VAdd 31.24%1,090,9090.02
≡KURA – KURA ONCOLOGY INCBuy48,2000.02
≡SYRS – SYROS PHARMACEUTICALS INCBuy116,7540.01
≡CAREMAX INCBuy122,6430.01
≡VBI VACCINES INC CDAReduce 8.66%−119,645−0.00
≡CYPH – LEAP THERAPEUTICS INCSell−44,971−0.00
≡BIOATLA INCSell−73,000−0.00
≡EYPTPUT – EYEPOINT PHARMACEUTICALS INCSell−750,000−0.00
≡RYTM – RHYTHM PHARMACEUTICALS INCAdd 465.64%1,773,2821.92
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 24.29%−2,756,499−1.86
≡CARGO THERAPEUTICS INCBuy3,436,6001.78
≡ROIV – ROIVANT SCIENCES LTDSell−3,819,456−1.49
≡SYRE – SPYRE THERAPEUTICS INCAdd 3113.52%2,525,5631.22
≡HRMY – HARMONY BIOSCIENCES HLDGS INSell−996,306−1.09
≡AMLX – AMYLYX PHARMACEUTICALS INCReduce 30.49%−819,748−1.03
≡NUVL – NUVALENT INCAdd 18.45%454,5401.02
≡BHVN – BIOHAVEN LTDAdd 129.45%973,2271.00
≡ARCELLX INCAdd 14.59%578,8310.88
≡NTRA – NATERA INCAdd 289.69%632,0470.87
≡ABBV – ABBVIE INCBuy238,0000.82
≡PCVX – VAXCYTE INCReduce 18.94%−254,265−0.76
≡AXSM – AXSOME THERAPEUTICS INCAdd 115.51%556,3700.72
≡RVMD – REVOLUTION MEDICINES INCReduce 38.05%−502,913−0.70
≡TNGX – TANGO THERAPEUTICS INCReduce 54.04%−1,307,098−0.66
≡COGT – COGENT BIOSCIENCES INCReduce 51.38%−1,186,512−0.60
≡RLAY – RELAY THERAPEUTICS INCSell−1,943,097−0.55
≡VRCA – VERRICA PHARMACEUTICALS INCAdd 40.89%2,060,1990.51
≡CELC – CELCUITY INCBuy1,481,3000.48
≡EOLS – EVOLUS INCAdd 166.75%2,477,6230.48
≡TMCI – TREACE MED CONCEPTS INCReduce 31.82%−583,655−0.45
≡CABA – CABALETTA BIO INCAdd 76.87%870,5670.44
≡XENE – XENON PHARMACEUTICALS INCAdd 78.26%483,2480.43
≡SPRINGWORKS THERAPEUTICS INCAdd 28.73%436,8300.42
≡ISRG – INTUITIVE SURGICAL INCBuy55,0000.41
≡ESTA – ESTABLISHMENT LABS HLDGS INCReduce 70.36%−195,384−0.41
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 63.65%−671,013−0.39
≡ASND – ASCENDIS PHARMAA/SBuy132,1760.37
≡MIRM – MIRUM PHARMACEUTICALS INCReduce 20.40%−137,100−0.36
≡BMEA – BIOMEA FUSIONSell−716,441−0.33
≡ARVN – ARVINAS INCBuy354,0820.33
≡VRDN – VIRIDIAN THERAPEUTICS INCAdd 71.10%719,0070.32
≡APLT – APPLIED THERAPEUTICS INCBuy4,080,2490.31
≡EYPT – EYEPOINT PHARMACEUTICALS INCBuy589,6460.30
≡PRTA – PROTHENA CORP PLCSell−165,615−0.27
≡AUTL – AUTOLUS THERAPEUTICS PLCBuy1,831,1670.26
≡MDT – MEDTRONIC PLCAdd 66.38%389,6520.26
≡OUTSET MED INCSell−661,977−0.24
≡SRPT – SAREPTA THERAPEUTICS INCAdd 147.30%269,1530.23
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 70.05%111,5520.20
≡ADMA – ADMA BIOLOGICS INCReduce 7.89%−550,950−0.18
≡AKROCALL – AKERO THERAPEUTICS INCSell−800,000−0.18
≡MDGL – MADRIGAL PHARMACEUTICALS INCAdd 21.27%26,5140.17
≡INTRA-CELLULAR THERAPIES INCBuy108,0000.17
≡OLMA – OLEMA PHARMACEUTICALS INCBuy539,8310.17
≡ASTRIA THERAPEUTICS INCAdd 82.88%1,814,6080.14
≡RGNX – REGENXBIO INCBuy342,4080.14
≡EWTX – EDGEWISE THERAPEUTICS INCBuy555,5550.14
≡MGNX – MACROGENICS INCBuy611,9320.13
≡RAPT THERAPEUTICS INCAdd 11.42%219,2920.12
≡NAUT – NAUTILUS BIOTECHNOLOGY INCAdd 38.23%3,483,060−0.12
≡SOMALOGIC INCSell−1,500,000−0.12
≡MLTX – MOONLAKE IMMUNOTHERAPEUTICSBuy82,3980.11
≡RCKT – ROCKET PHARMACEUTICALS INCAdd 12.52%189,9310.11
≡SRPTCALL – SAREPTA THERAPEUTICS INCSell−100,000−0.10
≡POINT BIOPHARMA GLOBAL INCSell−800,000−0.09
≡ARQTPUT – ARCUTIS BIOTHERAPEUTICS INCSell−300,000−0.09
≡IRON – DISC MEDICINE INCAdd 14.22%127,404−0.08
≡ACAD – ACADIA PHARMACEUTICALS INCBuy101,0000.07
≡NVNO – ENVVENO MEDICAL CORPORATIONReduce 20.25%−158,300−0.07
≡ACELYRIN INCSell−200,000−0.07
≡VERU – VERU INCAdd 412.42%4,494,8210.06
≡ZYME – ZYMEWORKS INCReduce 25.68%−371,316−0.06
≡CYTK – CYTOKINETICS INCBuy30,3170.06
≡89BIO INCSell−400,000−0.05
≡ACRSPUT – ACLARIS THERAPEUTICS INCSell−500,000−0.05
≡MORPHIC HLDGS INCBuy56,9800.04
≡ATHIRA PHARMA INCAdd 12.63%605,686−0.03
≡XBIPUT – SPDR SER TRBuy1,900,0000.03
≡AMBRX BIOPHARMA INCBuy78,8110.03
≡AXGN – AXOGEN INCReduce 7.71%−67,518−0.02
≡NVAXPUT – NOVAVAX INCAdd 7.69%100,000−0.02
≡APLTCALL – APPLIED THERAPEUTICS INCBuy500,0000.01
≡SINGULAR GENOMICS SYSTEMS INReduce 10.00%−236,321−0.01
≡VKTXCALL – VIKING THERAPEUTICS INCSell−300,000−0.01
≡BIOATLA INCBuy73,0000.00
≡APELLIS PHARMACEUTICALS INCSell−100,000−0.00
≡REVOLUTION MEDICINES INCBuy250,0000.00
≡MOTUS GI HLDGS INCSell−90,027−0.00
≡EQRX INCSell−250,000−0.00
≡
ARGX – ARGENX SE
Add 118.26%
81,600
1.69
≡MDGL – MADRIGAL PHARMACEUTICALS INCReduce 58.86%−178,350−1.42
≡AMLX – AMYLYX PHARMACEUTICALS INCReduce 44.83%−2,185,046−1.40
≡VIR – VIR BIOTECHNOLOGY INCSell−1,958,264−1.39
≡APGE – APOGEE THERAPEUTICS INCBuy1,827,9011.30
≡RVMD – REVOLUTION MEDICINES INCBuy1,321,7951.22
≡NUVL – NUVALENT INCAdd 12.24%268,6301.10
≡IOVA – IOVANCE BIOTHERAPEUTICS INCReduce 14.77%−2,073,472−1.04
≡TNGX – TANGO THERAPEUTICS INCBuy2,418,9680.91
≡TMCI – TREACE MED CONCEPTS INCReduce 17.28%−383,190−0.84
≡CYMABAY THERAPEUTICS INCAdd 8.30%309,9360.83
≡ILMN – ILLUMINA INCSell−145,000−0.79
≡MIRATI THERAPEUTICS INCSell−719,103−0.75
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 43.08%−765,181−0.71
≡BMRN – BIOMARIN PHARMACEUTICAL INCSell−263,207−0.66
≡XENE – XENON PHARMACEUTICALS INCReduce 49.52%−605,877−0.66
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 28.27%−415,488−0.59
≡RAYZEBIO INCBuy776,8050.58
≡ROIV – ROIVANT SCIENCES LTDAdd 21.96%687,7200.57
≡AXSM – AXSOME THERAPEUTICS INCAdd 77.41%210,1560.56
≡VERONA PHARMA PLCReduce 8.87%−389,919−0.51
≡SRPT – SAREPTA THERAPEUTICS INCAdd 125.37%101,6460.47
≡EOLS – EVOLUS INCBuy1,485,8010.45
≡INTRA-CELLULAR THERAPIES INCSell−245,800−0.45
≡IRON – DISC MEDICINE INCAdd 20.57%152,8030.45
≡ADMA – ADMA BIOLOGICS INCReduce 41.31%−4,915,936−0.44
≡BHVN – BIOHAVEN LTDAdd 134.34%431,0000.43
≡ESTA – ESTABLISHMENT LABS HLDGS INCReduce 34.65%−147,241−0.39
≡RCKT – ROCKET PHARMACEUTICALS INCAdd 29.88%349,1040.37
≡MDT – MEDTRONIC PLCAdd 25.70%120,0000.34
≡OUTSET MED INCReduce 26.64%−240,383−0.33
≡NBIX – NEUROCRINE BIOSCIENCES INCAdd 59.16%59,1920.32
≡ZYME – ZYMEWORKS INCReduce 40.15%−970,109−0.30
≡OBIO – ORCHESTRA BIOMED HLDGS INCAdd 18.47%379,2210.29
≡RYTM – RHYTHM PHARMACEUTICALS INCBuy380,8280.29
≡TERNS PHARMACEUTICALS INCSell−1,075,000−0.27
≡MIRM – MIRUM PHARMACEUTICALS INCAdd 11.72%70,4760.26
≡NTRA – NATERA INCReduce 46.16%−187,091−0.25
≡AXGN – AXOGEN INCReduce 40.20%−588,924−0.24
≡CRNX – CRINETICS PHARMACEUTICALS INReduce 35.09%−683,2050.24
≡VKTX – VIKING THERAPEUTICS INCSell−441,147−0.21
≡IVERIC BIO INCSell−168,000−0.19
≡AKROCALL – AKERO THERAPEUTICS INCBuy800,0000.18
≡HRMY – HARMONY BIOSCIENCES HLDGS INAdd 11.77%104,9360.18
≡TERNS PHARMACEUTICALS INCBuy1,075,0000.18
≡RAPT THERAPEUTICS INCReduce 16.07%−367,835−0.17
≡COGT – COGENT BIOSCIENCES INCReduce 13.16%−350,000−0.16
≡NVAXPUT – NOVAVAX INCBuy1,300,0000.13
≡INBX – INHIBRX INCAdd 17.44%631,922−0.12
≡AKRO – AKERO THERAPEUTICS INCReduce 16.55%−321,2500.11
≡SRPTCALL – SAREPTA THERAPEUTICS INCBuy100,0000.10
≡TCMD – TACTILE SYS TECHNOLOGY INCAdd 17.39%104,782−0.10
≡PRTA – PROTHENA CORP PLCReduce 10.29%−19,000−0.10
≡QTRX – QUANTERIX CORPSell−130,000−0.08
≡EYPTPUT – EYEPOINT PHARMACEUTICALS INCBuy750,0000.08
≡TVTX – TRAVERE THERAPEUTICS INCAdd 340.78%309,2520.08
≡FBRX – FORTE BIOSCIENCES INCBuy3,265,3590.07
≡POINT BIOPHARMA GLOBAL INCAdd 60.00%300,0000.07
≡89BIO INCBuy400,0000.05
≡CYPH – LEAP THERAPEUTICS INCReduce 92.34%−541,762−0.05
≡PCVX – VAXCYTE INCReduce 16.81%−271,371−0.05
≡ACRSPUT – ACLARIS THERAPEUTICS INCBuy500,0000.05
≡SYRE – AEGLEA BIOTHERAPEUTICS INCBuy81,1160.03
≡VERU – VERU INCAdd 1112.62%1,000,0000.02
≡MIRATI THERAPEUTICS INCSell−200,000−0.02
≡VERONA PHARMA PLCSell−500,000−0.02
≡VKTXCALL – VIKING THERAPEUTICS INCBuy300,0000.01
≡NBTX – NANOBIOTIXReduce 47.63%−504,7340.01
≡XBIPUT – SPDR SER TRSell−150,000−0.00
≡APELLIS PHARMACEUTICALS INCBuy100,0000.00
≡CABA – CABALETTA BIO INCReduce 26.70%−412,509−0.00
≡BIOXCEL THERAPEUTICS INCSell−439,500−0.00