| PRAXhist | PRAXIS PRECISION MEDICINES I | 10.23 | — | 2,035,986 | $334.79 | $681.63M |
| SYREhist | SPYRE THERAPEUTICS INC | 5.76 | Add 14.17% | 4,319,496 | $88.78 | $383.49M |
| CELChist | CELCUITY INC | 5.02 | Add 2.24% | 3,197,200 | $104.62 | $334.49M |
| ASNDhist | ASCENDIS PHARMA A/S | 4.66 | Reduce 24.01% | 1,163,721 | $266.72 | $310.39M |
| RYTMhist | RHYTHM PHARMACEUTICALS INC | 4.31 | Add 8.95% | 2,586,295 | $111.03 | $287.16M |
| ROIVhist | ROIVANT SCIENCES LTD | 4.30 | Reduce 2.41% | 8,085,461 | $35.39 | $286.14M |
| RLAYhist | RELAY THERAPEUTICS INC | 3.96 | Add 44.66% | 14,106,187 | $18.71 | $263.93M |
| TVTXhist | TRAVERE THERAPEUTICS INC | 3.20 | Reduce 9.41% | 3,752,574 | $56.81 | $213.18M |
| KARDhist | KARDIGAN INC | 2.94 | Buy | 8,200,662 | $23.85 | $195.59M |
| NUVLhist | NUVALENT INC | 2.93 | — | 1,580,505 | $123.50 | $195.19M |
| EWTXhist | EDGEWISE THERAPEUTICS INC | 2.67 | Reduce 1.13% | 4,373,974 | $40.63 | $177.72M |
| APGEhist | APOGEE THERAPEUTICS INC | 2.61 | Reduce 15.08% | 1,308,113 | $132.73 | $173.63M |
| AMLXhist | AMYLYX PHARMACEUTICALS INC | 2.25 | Add 0.60% | 8,334,882 | $17.96 | $149.69M |
| MGTXhist | MEIRAGTX HLDGS PLC | 2.19 | Add 4.46% | 10,786,658 | $13.51 | $145.73M |
| ORKAhist | ORUKA THERAPEUTICS INC | 1.92 | Reduce 3.61% | 1,345,063 | $95.17 | $128.01M |
| INBXhist | INHIBRX BIOSCIENCES INC | 1.85 | Reduce 10.05% | 1,297,763 | $94.75 | $122.96M |
| PTGXhist | PROTAGONIST THERAPEUTICS INC | 1.81 | Reduce 20.23% | 981,879 | $122.58 | $120.36M |
| SLDBhist | SOLID BIOSCIENCES INC | 1.79 | — | 11,906,646 | $9.99 | $118.95M |
| ZYMEhist | ZYMEWORKS INC | 1.64 | Add 19.17% | 4,182,953 | $26.14 | $109.34M |
| TNGXhist | TANGO THERAPEUTICS INC | 1.58 | Add 317.87% | 3,377,000 | $31.26 | $105.56M |
| IMTXhist | IMMATICS N.V | 1.58 | — | 10,383,456 | $10.13 | $105.18M |
| NRIXhist | NURIX THERAPEUTICS INC | 1.57 | Add 16.43% | 4,320,422 | $24.26 | $104.81M |
| BCRXhist | BIOCRYST PHARMACEUTICALS INC | 1.55 | Add 38.67% | 10,308,888 | $10.00 | $103.09M |
| RVMDhist | REVOLUTION MEDICINES INC | 1.48 | Add 104.02% | 527,600 | $187.28 | $98.81M |
| AVLNhist | AVALYN PHARMACEUTICALS INC | 1.32 | Buy | 2,675,296 | $32.92 | $88.07M |
| MRNAPUThist | MODERNA INC | 1.05 | — | 1,000,000 | $70.03 | $70.03M |
| DYNhist | DYNE THERAPEUTICS INC | 0.90 | Reduce 42.40% | 2,689,235 | $22.21 | $59.73M |
| BIIBhist | BIOGEN INC | 0.90 | Buy | 276,173 | $216.06 | $59.67M |
| IMVThist | IMMUNOVANT INC | 0.79 | Reduce 15.02% | 1,357,383 | $38.53 | $52.30M |
| UNHhist | UNITEDHEALTH GROUP INC | 0.73 | Buy | 116,806 | $415.63 | $48.55M |
| XBIPUThist | SPDR SERIES TRUST | 0.71 | Buy | 300,000 | $158.25 | $47.48M |
| IONShist | IONIS PHARMACEUTICALS INC | 0.67 | Add 12.30% | 566,000 | $79.29 | $44.88M |
| STROhist | SUTRO BIOPHARMA INC | 0.65 | Add 82.42% | 1,304,846 | $33.20 | $43.32M |
| ANROhist | ALTO NEUROSCIENCE INC | 0.64 | Reduce 19.90% | 1,609,893 | $26.39 | $42.48M |
| JAZZhist | JAZZ PHARMACEUTICALS PLC | 0.61 | — | 170,000 | $240.97 | $40.97M |
| CRVShist | CORVUS PHARMACEUTICALS INC | 0.60 | Add 16.36% | 2,667,441 | $14.94 | $39.85M |
| SIONhist | SIONNA THERAPEUTICS INC | 0.60 | Add 37.45% | 905,000 | $43.99 | $39.81M |
| CTMXhist | CYTOMX THERAPEUTICS INC. | 0.59 | Add 3.37% | 10,439,185 | $3.75 | $39.15M |
| AORThist | ARTIVION INC | 0.59 | Add 6.11% | 1,737,290 | $22.47 | $39.04M |
| XFORhist | X4 PHARMACEUTICALS INC | 0.56 | Add 17.75% | 7,933,491 | $4.67 | $37.05M |
| CORThist | CORCEPT THERAPEUTICS INC | 0.52 | Add 696.77% | 398,385 | $86.95 | $34.64M |
| RGENhist | REPLIGEN CORP | 0.51 | Reduce 11.52% | 248,212 | $136.44 | $33.87M |
| AVRhist | ANTERIS TECHNOLOGIES GLOBAL | 0.51 | — | 3,425,476 | $9.85 | $33.74M |
| RAPPhist | RAPPORT THERAPEUTICS INC | 0.48 | Add 14.75% | 773,342 | $41.67 | $32.23M |
| DMRAhist | DAMORA THERAPEUTICS INC | 0.48 | — | 1,223,000 | $26.01 | $31.81M |
| CRLhist | CHARLES RIV LABS INTL INC | 0.48 | Buy | 140,000 | $226.79 | $31.75M |
| AXSMhist | AXSOME THERAPEUTICS INC. | 0.44 | Reduce 21.01% | 118,450 | $244.77 | $28.99M |
| EYPTPUThist | EYEPOINT INC | 0.43 | Buy | 2,000,000 | $14.30 | $28.60M |
| DBVThist | DBV TECHNOLOGIES S A | 0.41 | Add 71.44% | 1,653,350 | $16.40 | $27.11M |
| IRTChist | IRHYTHM HOLDINGS INC | 0.40 | Add 113.06% | 223,766 | $118.95 | $26.62M |
| ADPThist | ADAPTIVE BIOTECHNOLOGIES COR | 0.39 | Add 698.25% | 1,217,325 | $21.45 | $26.11M |
| SABShist | SAB BIOTHERAPEUTICS INC | 0.39 | Add 3.04% | 6,627,501 | $3.90 | $25.85M |
| DHRhist | DANAHER CORP DEL | 0.37 | Buy | 130,000 | $190.48 | $24.76M |
| TENXhist | TENAX THERAPEUTICS INC | 0.37 | Add 17.42% | 1,700,000 | $14.55 | $24.73M |
| CAPRCALLhist | CAPRICOR THERAPEUTICS INC | 0.36 | Buy | 1,000,000 | $24.08 | $24.08M |
| SLSPUThist | SELLAS LIFE SCIENCES GROUP I | 0.33 | Buy | 1,500,000 | $14.76 | $22.14M |
| NAUThist | NAUTILUS BIOTECHNOLOGY INC | 0.33 | Reduce 7.62% | 11,634,211 | $1.87 | $21.76M |
| OBIOhist | ORCHESTRA BIOMED HLDGS INC | 0.33 | — | 5,037,906 | $4.32 | $21.74M |
| ISRGhist | INTUITIVE SURGICAL INC | 0.31 | Reduce 39.26% | 51,884 | $397.68 | $20.63M |
| ANLhist | ADLAI NORTYE LTD | 0.31 | Buy | 1,793,190 | $11.50 | $20.62M |
| CTNMhist | CONTINEUM THERAPEUTICS INC | 0.31 | — | 1,255,592 | $16.39 | $20.58M |
| NVCThist | NUVECTIS PHARMA INC | 0.28 | Buy | 1,000,000 | $18.39 | $18.39M |
| PALIhist | PALISADE BIO INC | 0.26 | Reduce 5.63% | 8,425,065 | $2.09 | $17.61M |
| OMDAhist | OMADA HEALTH INC | 0.26 | — | 786,330 | $21.95 | $17.26M |
| LONAhist | LEONABIO INC | 0.26 | — | 1,859,322 | $9.19 | $17.09M |
| EOLShist | EVOLUS INC | 0.26 | Add 91.11% | 2,459,285 | $6.94 | $17.07M |
| NAMSPUThist | NEWAMSTERDAM PHARMA COMPANY | 0.25 | Buy | 500,000 | $33.89 | $16.95M |
| IVVDhist | INVIVYD INC | 0.24 | Reduce 11.36% | 18,490,636 | $0.87 | $16.13M |
| — | CELCUITY INC | 0.22 | — | 6,500,000 | $2.25 | $14.63M |
| MIRMhist | MIRUM PHARMACEUTICALS INC | 0.20 | Buy | 115,391 | $117.07 | $13.51M |
| SRZNhist | SURROZEN INC | 0.20 | Add 119.70% | 503,985 | $25.95 | $13.08M |
| BBNXhist | BETA BIONICS INC | 0.20 | Reduce 1.19% | 832,944 | $15.67 | $13.05M |
| CAPRPUThist | CAPRICOR THERAPEUTICS INC | 0.18 | Buy | 500,000 | $24.08 | $12.04M |
| AXGNhist | AXOGEN INC | 0.17 | Reduce 64.53% | 247,312 | $46.19 | $11.42M |
| OSCRhist | OSCAR HEALTH INC | 0.17 | Buy | 400,000 | $28.52 | $11.41M |
| OCShist | OCULIS HOLDING AG | 0.17 | Add 63.79% | 808,827 | $13.87 | $11.22M |
| SPTXhist | SEAPORT THERAPEUTICS INC | 0.16 | Buy | 500,000 | $21.72 | $10.86M |
| VRDNhist | VIRIDIAN THERAPEUTICS INC | 0.16 | Reduce 50.29% | 581,980 | $18.37 | $10.69M |
| BSXhist | BOSTON SCIENTIFIC CORP | 0.16 | Buy | 250,000 | $42.68 | $10.67M |
| BLLNhist | BILLIONTOONE INC | 0.16 | Reduce 5.45% | 86,812 | $119.98 | $10.42M |
| ABVXhist | ABIVAX SA | 0.15 | Reduce 77.50% | 74,000 | $133.26 | $9.86M |
| NTRAhist | NATERA INC | 0.14 | Buy | 34,689 | $271.44 | $9.42M |
| ENGNhist | ENGENE THERAPEUTICS INC | 0.13 | Reduce 17.25% | 4,822,169 | $1.73 | $8.34M |
| RACChist | RESEARCH ALLIANCE CORP III | 0.12 | Buy | 750,000 | $10.70 | $8.03M |
| AGMBhist | AGOMAB THERAPEUTICS NV | 0.12 | — | 600,000 | $12.98 | $7.79M |
| CGEMhist | CULLINAN THERAPEUTICS INC | 0.12 | Buy | 426,478 | $18.21 | $7.77M |
| QUREhist | UNIQURE NV | 0.12 | Buy | 168,000 | $46.06 | $7.74M |
| MOBIhist | MOBIA MED INC | 0.11 | Buy | 523,654 | $13.40 | $7.02M |
| ADGMhist | ADAGIO MED HLDGS INC | 0.10 | — | 9,876,586 | $0.65 | $6.44M |
| GHhist | GUARDANT HEALTH INC | 0.09 | Reduce 86.22% | 41,327 | $150.02 | $6.20M |
| PHAThist | PHATHOM PHARMACEUTICALS INC | 0.09 | Reduce 42.49% | 532,000 | $10.85 | $5.77M |
| OTLKhist | OUTLOOK THERAPEUTICS INC | 0.07 | Buy | 3,139,216 | $1.59 | $4.99M |
| COGThist | COGENT BIOSCIENCES INC | 0.07 | — | 121,082 | $38.70 | $4.69M |
| EDSAhist | EDESA BIOTECH INC | 0.07 | — | 563,239 | $8.13 | $4.58M |
| AVTXhist | AVALO THERAPEUTICS INC | 0.06 | Add 57.38% | 219,813 | $18.48 | $4.06M |
| TWSThist | TWIST BIOSCIENCE CORP | 0.06 | Reduce 75.46% | 36,812 | $102.87 | $3.79M |
| CBIOhist | CRESCENT BIOPHARMA INC. | 0.06 | — | 206,942 | $18.00 | $3.73M |
| XERShist | XERIS BIOPHARMA HOLDINGS INC | 0.06 | Buy | 467,013 | $7.92 | $3.70M |
| OMhist | OUTSET MED INC | 0.05 | — | 833,333 | $4.32 | $3.60M |
| BDSXhist | BIODESIX INC | 0.04 | Buy | 108,694 | $22.55 | $2.45M |
| — | REVOLUTION MEDICINES INC | 0.04 | — | 250,000 | $9.38 | $2.35M |
| CNTBhist | CONNECT BIOPHARMA HLDGS LTD | 0.03 | — | 792,696 | $2.38 | $1.89M |
| KPRXhist | KIORA PHARMACEUTICALS INC | 0.02 | Buy | 438,471 | $2.63 | $1.15M |
| MDLNhist | MEDLINE INC | 0.02 | — | 28,000 | $39.43 | $1.10M |
| ADMAhist | ADMA BIOLOGICS INC | 0.01 | Reduce 75.65% | 113,765 | $8.37 | $952K |
| CPIXhist | CUMBERLAND PHARMACEUTICALS I | 0.01 | Reduce 50.77% | 96,982 | $6.48 | $628K |
| XGNhist | EXAGEN INC | 0.01 | — | 114,893 | $4.65 | $534K |
| ENSChist | ENSYSCE BIOSCIENCES INC | 0.00 | — | 86,666 | $0.29 | $25K |
| — | SURROZEN INC | 0.00 | — | 166,666 | $0.02 | $3K |
| CNTAhist | CENTESSA PHARMACEUTICALS PLC | 0.00 | Sell | 0 | — | $0 |
| — | DAY ONE BIOPHARMACEUTICALS I | 0.00 | Sell | 0 | — | $0 |
| DRUGhist | BRIGHT MINDS BIOSCIENCES INC | 0.00 | Sell | 0 | — | $0 |
| BLTEhist | BELITE BIO INC | 0.00 | Sell | 0 | — | $0 |
| EVMNhist | EVOMMUNE INC | 0.00 | Sell | 0 | — | $0 |
| NMRAhist | NEUMORA THERAPEUTICS INC. | 0.00 | Sell | 0 | — | $0 |
| NBIXhist | NEUROCRINE BIOSCIENCES INC | 0.00 | Sell | 0 | — | $0 |
| IRDhist | OPUS GENETICS INC | 0.00 | Sell | 0 | — | $0 |
| OCULCALLhist | OCULAR THERAPEUTIX INC | 0.00 | Sell | 0 | — | $0 |
| IKThist | INHIBIKASE THERAPEUTICS INC | 0.00 | Sell | 0 | — | $0 |
| — | APELLIS PHARMACEUTICALS INC | 0.00 | Sell | 0 | — | $0 |
| PTNhist | PALATIN TECHNOLOGIES INC | 0.00 | Sell | 0 | — | $0 |