Joseph Edelman – Perceptive Advisors LLC

Period:
Q1 2026
Portfolio date:
Mar 31, 2026
No. of stocks:
91
Portfolio value:
$5,110,912,000
Filed:
May 15, 2026
Style:
Biotech Specialist
HistStockActivityShare change% change to portfolio
Q1 2026filed May 15, 2620 new17 added22 reduced42 exited
≡XBIPUT – SPDR SERIES TRUSTSell−1,100,000−2.39
≡EXAS – EXACT SCIENCES CORPSell−1,200,487−2.17
≡ACLX – ARCELLX INCSell−1,466,071−1.70
≡BSX – BOSTON SCIENTIFIC CORPSell−979,000−1.66
≡AMICUS THERAPEUTICS INCSell−6,370,851−1.62
≡ASTRIA THERAPEUTICS INCSell−6,485,420−1.51
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 62.00%−1,871,874−1.24
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 7.00%−172,596−0.82
≡DHR – DANAHER CORPORATIONSell−200,000−0.82
≡BLTE – BELITE BIO INCReduce 63.00%−262,260−0.71
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 80.00%−266,000−0.67
≡CDTX – CIDARA THERAPEUTICS INCSell−165,131−0.65
≡IRON – DISC MEDICINE INCSell−450,743−0.64
≡PEN – PENUMBRA INCSell−110,529−0.61
≡APGE – APOGEE THERAPEUTICS INCReduce 34.00%−790,267−0.60
≡CAI – CARIS LIFE SCIENCES INCSell−1,136,206−0.55
≡RAPT THERAPEUTICS INCSell−825,890−0.50
≡PVLA – PALVELLA THERAPEUTICS INC NESell−266,287−0.50
≡OMDA – OMADA HEALTH INCReduce 67.00%−1,610,000−0.48
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 9.00%−119,5460.44
≡KOD – KODIAK SCIENCES INCSell−848,900−0.42
≡BIIB – BIOGEN INCSell−124,000−0.39
≡ALDX – ALDEYRA THERAPEUTICS INCSell−4,185,632−0.39
≡ABVX – ABIVAX SAReduce 28.00%−129,459−0.39
≡MIRM – MIRUM PHARMACEUTICALS INCSell−259,545−0.37
≡GRAL – GRAIL INCSell−237,342−0.36
≡SION – SIONNA THERAPEUTICS INCReduce 44.00%−520,659−0.35
≡CVS – CVS HEALTH CORPSell−220,000−0.31
≡GKOS – GLAUKOS CORPSell−140,000−0.28
≡RGEN – REPLIGEN CORPReduce 11.00%−35,000−0.27
≡DXCM – DEXCOM INCSell−225,758−0.27
≡SVRA – SAVARA INCSell−2,400,000−0.26
≡SEPN – SEPTERNA INCSell−433,160−0.22
≡ADMA – ADMA BIOLOGICS INCReduce 47.00%−416,235−0.20
≡PALI – PALISADE BIO INCReduce 26.00%−3,121,851−0.20
≡GOSS – GOSSAMER BIO INCSell−3,139,669−0.17
≡MPLT – MAPLIGHT THERAPEUTICS INCSell−550,000−0.17
≡XENE – XENON PHARMACEUTICALS INCSell−200,791−0.16
≡KMTS – KESTRA MED TECHNOLOGIES LTDSell−285,000−0.13
≡IMVT – IMMUNOVANT INCReduce 20.00%−397,507−0.13
≡CAPRCALL – CAPRICOR THERAPEUTICS INCSell−242,100−0.12
≡IKT – INHIBIKASE THERAPEUTICS INCReduce 57.00%−3,106,568−0.12
≡BHVNCALL – BIOHAVEN LTDSell−500,000−0.10
≡ADGM – ADAGIO MED HLDGS INCReduce 62.00%−6,095,746−0.10
≡KYMR – KYMERA THERAPEUTICS INCSell−69,935−0.10
≡PEPG – PEPGEN INCSell−829,870−0.10
≡TECXCALL – TECTONIC THERAPEUTIC INCSell−250,000−0.09
≡AQST – AQUESTIVE THERAPEUTICS INCSell−747,193−0.09
≡DRUG – BRIGHT MINDS BIOSCIENCES INCReduce 16.00%−71,746−0.09
≡KRYS – KRYSTAL BIOTECH INCSell−17,500−0.08
≡OLMA – OLEMA PHARMACEUTICALS INCSell−165,713−0.07
≡SDGR – SCHRODINGER INCSell−202,400−0.06
≡IMMX – IMMIX BIOPHARMA INCSell−338,941−0.03
≡LXEO – LEXEO THERAPEUTICS INCSell−139,835−0.02
≡CTNM – CONTINEUM THERAPEUTICS INCReduce 14.00%−209,0000.02
≡CBIO – CRESCENT BIOPHARMA INC.Reduce 54.00%−246,744−0.02
≡LENZ – LENZ THERAPEUTICS INCSell−50,000−0.01
≡BDSX – BIODESIXSell−108,694−0.01
≡CPIX – CUMBERLAND PHARMACEUTICALS IReduce 42.00%−144,109−0.01
≡NVNO – ENVVENO MEDICAL CORPORATIONSell−1,759,035−0.01
≡IRD – OPUS GENETICS INCReduce 58.00%−2,489,1580.01
≡IOVA – IOVANCE BIOTHERAPEUTICS INCSell−152,714−0.01
≡AXGN – AXOGEN INCReduce 11.00%−86,828−0.01
≡PTN – PALATIN TECHNOLOGIES INCReduce 12.00%−8,0550.00
Q4 2025filed Feb 17, 2641 new31 added17 reduced15 exited
≡ACLX – ARCELLX INCReduce 41.00%−1,002,282−4.02
≡MERUS N VSell−1,353,093−3.60
≡INSM – INSMED INCSell−702,130−2.86
≡AMLX – AMYLYX PHARMACEUTICALS INCReduce 7.00%−667,483−1.65
≡VRNA – VERONA PHARMA PLCSell−524,088−1.58
≡AKERO THERAPEUTICS INCSell−1,135,766−1.52
≡MGTX – MEIRAGTX HLDGS PLCReduce 18.00%−2,300,000−1.47
≡AORT – ARTIVION INCReduce 15.00%−297,710−1.02
≡PEN – PENUMBRA INCReduce 50.00%−110,018−0.97
≡NBIX – NEUROCRINE BIOSCIENCES INCReduce 26.00%−119,000−0.95
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 6.00%−183,268−0.82
≡AQST – AQUESTIVE THERAPEUTICS INCReduce 80.00%−3,012,906−0.51
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 20.00%−1,036,679−0.38
≡IRTC – IRHYTHM TECHNOLOGIES INCReduce 12.00%−15,000−0.26
≡CRVS – CORVUS PHARMACEUTICALS INCReduce 52.00%−746,154−0.20
≡PVLA – PALVELLA THERAPEUTICS INC NEReduce 33.00%−128,806−0.20
≡JANX – JANUX THERAPEUTICS INCSell−292,686−0.20
≡TEM – TEMPUS AI INCSell−85,000−0.19
≡ADMA – ADMA BIOLOGICS INCReduce 23.00%−270,000−0.19
≡KYMR – KYMERA THERAPEUTICS INCReduce 59.00%−99,861−0.17
≡HTFL – HEARTFLOW INCSell−150,000−0.14
≡GOSS – GOSSAMER BIO INCReduce 18.00%−673,128−0.11
≡KRYS – KRYSTAL BIOTECH INCReduce 50.00%−17,500−0.10
≡SCPHARMACEUTICALS INCSell−583,142−0.09
≡VKTX – VIKING THERAPEUTICS INCSell−105,597−0.08
≡PYXS – PYXIS ONCOLOGY INCSell−1,178,307−0.07
≡SEPN – SEPTERNA INCReduce 20.00%−108,290−0.07
≡SPRYPUT – ARS PHARMACEUTICALS INCSell−200,000−0.06
≡TRIB – TRINITY BIOTECH PLCSell−1,790,000−0.05
≡LYRA – LYRA THERAPEUTICS INCSell−229,382−0.04
≡QURE – UNIQURE NVSell−20,000−0.03
≡APYX – APYX MEDICAL CORPORATIONSell−150,000−0.01
Q3 2025filed Nov 14, 2521 new28 added14 reduced13 exited
≡VRNA – VERONA PHARMA PLCReduce 90.00%−4,983,503−17.25
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 100.00%−2,418,299−4.34
≡SLNO – SOLENO THERAPEUTICS INCSell−430,439−1.30
≡XBIPUT – SPDR SERIES TRUSTSell−300,000−0.90
≡EOLS – EVOLUS INCSell−2,474,843−0.82
≡AORT – ARTIVION INCReduce 28.00%−773,703−0.73
≡PODD – INSULET CORPSell−60,387−0.69
≡BBNX – BETA BIONICS INCReduce 83.00%−1,315,664−0.68
≡DYN – DYNE THERAPEUTICS INCReduce 76.00%−1,706,946−0.58
≡CRL – CHARLES RIV LABS INTL INCSell−100,000−0.55
≡IMVT – IMMUNOVANT INCReduce 26.00%−550,000−0.51
≡EWTX – EDGEWISE THERAPEUTICS INCReduce 18.00%−844,055−0.46
≡ADMA – ADMA BIOLOGICS INCReduce 12.00%−150,000−0.38
≡RARE – ULTRAGENYX PHARMACEUTICAL INSell−270,000−0.35
≡VKTX – VIKING THERAPEUTICS INCReduce 72.00%−275,103−0.29
≡SYRE – SPYRE THERAPEUTICS INCReduce 20.00%−300,000−0.25
≡AXSM – AXSOME THERAPEUTICS INCReduce 25.00%−49,634−0.24
≡CAPRPUT – CAPRICOR THERAPEUTICS INCSell−650,000−0.23
≡GMED – GLOBUS MED INCSell−88,500−0.19
≡HLXC – HELIX ACQUISITION CORP IISell−398,000−0.15
≡AMICUS THERAPEUTICS INCReduce 14.00%−1,041,979−0.12
≡KYMR – KYMERA THERAPEUTICS INCReduce 19.00%−40,310−0.06
≡LONA – ATHIRA PHARMA INCSell−5,402,964−0.06
≡LYRA – LYRA THERAPEUTICS INCReduce 10.00%−25,768−0.04
≡FBRX – FORTE BIOSCIENCES INCSell−68,192−0.03
≡BDSX – BIODESIX INCSell−2,173,880−0.02
≡KALA – KALA BIO INCSell−55,227−0.01
Q2 2025filed Aug 14, 2522 new8 added27 reduced23 exited
≡AMICUS THERAPEUTICS INCReduce 65.00%−14,051,697−4.60
≡VRNA – VERONA PHARMA PLCReduce 16.00%−1,055,7494.23
≡INTRA-CELLULAR THERAPIES INCSell−786,358−3.64
≡SLNO – SOLENO THERAPEUTICS INCReduce 71.00%−1,076,163−2.47
≡IOVA – IOVANCE BIOTHERAPEUTICS INCSell−12,711,788−1.48
≡ALDX – ALDEYRA THERAPEUTICS INCReduce 56.00%−5,224,220−1.31
≡ARGX – ARGENX SESell−59,510−1.23
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 62.00%−1,893,460−0.99
≡PCVX – VAXCYTE INCSell−706,567−0.94
≡EOLS – EVOLUS INCReduce 40.00%−1,654,299−0.92
≡ACLX – ARCELLX INCReduce 15.00%−448,478−0.83
≡AXSM – AXSOME THERAPEUTICS INCReduce 44.00%−156,573−0.70
≡JANX – JANUX THERAPEUTICS INCReduce 70.00%−677,726−0.67
≡MDGL – MADRIGAL PHARMACEUTICALS INCSell−46,500−0.54
≡SYRE – SPYRE THERAPEUTICS INCReduce 34.00%−783,827−0.48
≡IMVT – IMMUNOVANT INCReduce 25.00%−706,182−0.47
≡DXCM – DEXCOM INCSell−178,000−0.43
≡ACRV – ACRIVON THERAPEUTICS INCSell−5,360,858−0.38
≡CRGX – CARGO THERAPEUTICS INCSell−2,431,085−0.35
≡EYPT – EYEPOINT PHARMACEUTICALS INCSell−1,537,274−0.29
≡NUVL – NUVALENT INCReduce 16.00%−258,788−0.27
≡IRON – DISC MEDICINE INCSell−150,000−0.26
≡CTNM – CONTINEUM THERAPEUTICS INCReduce 51.00%−741,763−0.25
≡ADPT – ADAPTIVE BIOTECHNOLOGIES CORSell−930,972−0.24
≡OCUL – OCULAR THERAPEUTIX INCSell−915,775−0.24
≡DCTH – DELCATH SYS INCSell−462,422−0.21
≡ZYME – ZYMEWORKS INCReduce 32.00%−589,398−0.20
≡RAPT THERAPEUTICS INCSell−4,418,947−0.19
≡KMTS – KESTRA MED TECHNOLOGIES LTDSell−200,000−0.17
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 23.00%−227,973−0.16
≡XENE – XENON PHARMACEUTICALS INCReduce 38.00%−124,533−0.16
≡OKUR – ONKURE THERAPEUTICS INCSell−1,004,439−0.15
≡AVTX – AVALO THERAPEUTICS INCReduce 73.00%−380,333−0.12
≡AQST – AQUESTIVE THERAPEUTICS INCReduce 41.00%−1,536,788−0.12
≡BBNX – BETA BIONICS INCReduce 28.00%−610,232−0.11
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 32.00%−212,155−0.09
≡IKT – INHIBIKASE THERAPEUTICS INCReduce 8.00%−492,707−0.07
≡MREO – MEREO BIOPHARMA GROUP PLCSell−876,961−0.07
≡VKTX – VIKING THERAPEUTICS INCReduce 25.00%−128,305−0.07
≡LYRA – LYRA THERAPEUTICS INCSell−12,757,562−0.06
≡CELC – CELCUITY INCReduce 31.00%−729,071−0.05
≡KALA – KALA BIO INCReduce 80.00%−222,383−0.05
≡AVR – ANTERIS TECHNOLOGIES GLOBALReduce 20.00%−434,870−0.04
≡TRAW – TRAWS PHARMA INCSell−421,781−0.03
≡RCKT – ROCKET PHARMACEUTICALS INCSell−140,726−0.03
≡PODD – INSULET CORPReduce 16.00%−11,2100.03
≡CGEM – CULLINAN THERAPEUTICS INCSell−80,100−0.02
≡INBX – INHIBRX BIOSCIENCES INCReduce 8.00%−86,134−0.02
≡APPLIED THERAPEUTICS INCSell−860,000−0.01
≡NBTX – NANOBIOTIXSell−105,053−0.01
Q1 2025filed May 15, 2515 new13 added29 reduced27 exited
≡IOVA – IOVANCE BIOTHERAPEUTICS INCReduce 43.00%−9,400,478−2.97
≡PCVX – VAXCYTE INCReduce 59.00%−1,011,850−2.89
≡EWTXCALL – EDGEWISE THERAPEUTICS INCReduce 81.00%−2,185,537−1.56
≡NUVL – NUVALENT INCReduce 38.00%−986,009−1.52
≡PRAX – PRAXIS PRECISION MEDICINES IReduce 26.00%−348,841−1.48
≡CNTA – CENTESSA PHARMACEUTICALS PLCReduce 52.00%−3,308,825−1.36
≡CRGX – CARGO THERAPEUTICS INCReduce 34.00%−1,251,919−1.10
≡PODD – INSULET CORPReduce 69.00%−160,672−0.99
≡RYTM – RHYTHM PHARMACEUTICALS INCReduce 31.00%−1,132,028−0.87
≡INTRA-CELLULAR THERAPIES INCReduce 39.00%−501,9700.71
≡VKTX – VIKING THERAPEUTICS INCReduce 49.00%−486,889−0.66
≡PRCT – PROCEPT BIOROBOTICS CORPSell−290,659−0.64
≡NTRA – NATERA INCSell−125,000−0.54
≡ACLX – ARCELLX INCReduce 16.00%−552,410−0.53
≡PTGX – PROTAGONIST THERAPEUTICS INCReduce 14.00%−180,3910.52
≡PEN – PENUMBRA INCSell−73,338−0.47
≡SEPN – SEPTERNA INCSell−750,000−0.47
≡VRDN – VIRIDIAN THERAPEUTICS INCReduce 56.00%−826,846−0.46
≡ORKA – ORUKA THERAPEUTICS INCSell−845,567−0.45
≡ARVN – ARVINAS INCSell−740,749−0.39
≡CGON – CG ONCOLOGY INCSell−419,450−0.33
≡SYRE – SPYRE THERAPEUTICS INCReduce 10.00%−261,451−0.32
≡EW – EDWARDS LIFESCIENCES CORPSell−145,000−0.29
≡TARS – TARSUS PHARMACEUTICALS INCSell−186,662−0.28
≡CRNX – CRINETICS PHARMACEUTICALS INSell−184,525−0.26
≡INARI MED INCSell−178,797−0.25
≡AKERO THERAPEUTICS INCReduce 33.00%−392,6320.23
≡EOLS – EVOLUS INCReduce 20.00%−1,016,7040.20
≡ISRG – INTUITIVE SURGICAL INCReduce 36.00%−22,500−0.19
≡ZBIO – ZENAS BIOPHARMA INCSell−744,035−0.17
≡IRTC – IRHYTHM TECHNOLOGIES INCSell−65,153−0.16
≡RAPP – RAPPORT THERAPEUTICS INCSell−311,551−0.15
≡CBLL – CERIBELL INCSell−180,546−0.13
≡VERU – VERU INCSell−6,483,157−0.11
≡ARGX – ARGENX SEReduce 12.00%−7,9610.11
≡CATX – PERSPECTIVE THERAPEUTICS INCSell−1,190,263−0.10
≡LCTX – LINEAGE CELL THERAPEUTICS INSell−7,236,843−0.10
≡RCKT – ROCKET PHARMACEUTICALS INCReduce 63.00%−237,858−0.10
≡PEPG – PEPGEN INCSell−829,536−0.09
≡IBRX – IMMUNITYBIO INCSell−1,221,734−0.09
≡AXSM – AXSOME THERAPEUTICS INCReduce 47.00%−308,967−0.08
≡BCYC – BICYCLE THERAPEUTICS PLCSell−197,108−0.08
≡AMICUS THERAPEUTICS INCReduce 11.00%−2,781,425−0.07
≡ZYME – ZYMEWORKS INCReduce 12.00%−265,348−0.07
≡RAPT THERAPEUTICS INCReduce 25.00%−1,461,053−0.06
≡VRCA – VERRICA PHARMACEUTICALS INCSell−3,249,669−0.06
≡FBRX – FORTE BIOSCIENCES INCSell−95,742−0.06
≡NRIX – NURIX THERAPEUTICS INCReduce 10.00%−33,061−0.05
≡TRIB – TRINITY BIOTECH PLCSell−1,790,000−0.04
≡MREO – MEREO BIOPHARMA GROUP PLCReduce 19.00%−208,551−0.03
≡FULC – FULCRUM THERAPEUTICS INCSell−238,000−0.03
≡NVAXPUT – NOVAVAX INCSell−100,000−0.02
≡OCUL – OCULAR THERAPEUTIX INCReduce 15.00%−162,720−0.02
≡HLXC – HELIX ACQUISITION CORP IIReduce 20.00%−102,0000.01
≡PYXS – PYXIS ONCOLOGY INCSell−188,462−0.01
≡NBTX – NANOBIOTIXReduce 61.00%−161,040−0.01